Online ISSN: 2515-8260

Keywords : Polymer


DEVELOPMENT AND CHARACTERIZATION OF CONTROLLED RELEASE TABLET BEARING ANTI HYPERTENSIVE DRUG

NIDHI SHARMA,PRANAV KUMAR UPADHYAY

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 623-636

Propranolol hydrochloride is used to treat high blood pressure, thyrotoxicosis, capillary
hemangiomas, performance anxiety, and essential tremors and used to prevent migraine
headaches. In this investigation-controlled release tablet of Propranolol Hcl was prepared
using different polymers such as xanthan gum, tragacanth, sodium carboxy-methylcellulose,
HPMC K4M, Eudragit S100, ethyl cellulose by direct compression method. All the precompression
and post compression parameters of designed formulations of F1-F8 were
evaluated and found to be within permissible limits. The optimized formulation (F7) showed
a maximum percentage of drug release (100%) within 6hrs when compared to other
formulations. From the FT-IR study it was concluded that there were no possible drug and
polymer interactions. The short-term stability studies were carried out at 40±2°C and 75±5%
RH and confirmed no changes in the weight, hardness and friability. Based on study results
it may be concluded that tablets prepared will emerge as eminent candidates in treatment of
hypertension.

Synthesis, Characterization and Investigation of New Polymer Contain Heterocyclic Derivatives as Corrosion Inhibitor for Stainless steel in acidic medium

Amaal S. Sadiq; Entesar O. Al- Tamimi

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 1567-1588

A new series of Poly 2-[N-(5-vinyl-1H-1,2,3-triazol-3-methyl amino]benzo[d]thiazole(4) has
been synthesized through reaction of 2-aminobenzimidazole with ethyl chloroacetate . The
resulting ester was synthetically modified through hydrazine hydrate to acyl hydrazide which
was condensed with acrylonitrile to afford the title 2-[N-(5-vinyl-1H-1,2,4-triazol-3-methyl)
amino] benzo[d]thiazole(3). Finally, Using a controlled DC power supply, compound [3]
electrochemical polymerization onto the S-steel (anode) electrode surface was carried out in a
potentiostat. The polymer-coated and uncoated stainless steel corrosion safety test was studied in
a solution of 0.2 M HCl, followed by Tafel and Potentiostatic procedures at temperature 293 K.
Nano materials such as ZnO were applied to the monomer solution at different concentrations to
enhance the resistance for corrosion the 316L stainless steel surface, so that tests showed that
the performance values of corrosion protection for the polymer coating increase with the
introduction of nano materials.[13C-NMR, 1H-NMR, and FTIR] were recorder to confirm the
structure of poylmers, measurement of some of its physical properties and atomic force
microscope(AFM), scanning electron microscope(SEM).

Analysis Of Nylon 6 As Microplastic In Harike Wetland By Comparing Its IR Spectra With Virgin Nylon 6 And 6.6

SHAISTA MANZOOR; HARPREET KAUR; RAHUL SINGH

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4294-4300

This study is based on different IR spectra of nylon 6 and nylon 6.6 who are most common plastic in environment comes from domestic and industrial waste. Study is focused on amid II band (C=O stretch ) Amid I band (NH bending) NH stretch. Water filter for sampling and collection of debris from Harike wetland was done with help of plankton net in winter season. By using standard digestion and density separation methods suspected miscroplastic collected and analyzed by FTIR. IR spectra of both virgin and sample were matched and found that nylon 6 is present in Harike wetland. The source of Nylon may be lateral invasion or from different water bodies who are integral part of Harike wetland.