Online ISSN: 2515-8260

Keywords : Antibacterial activity

Synthesis Of Heterocyclic Nitrogen Containing Compounds Including In Silico Toxicity And Structural Activity Relationship

S. Singh; Dr. Shamim Ahmad; Dr. Md Shamsher Alam; Huma khan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 6633-6645

In silico toxicology tools, steps to generate prediction models, and categories of prediction models. The purpose of this study is to provide a comprehensive overview of existing modeling methods and algorithms for toxicity prediction (element D above), with a particular (but not exclusive) emphasis on computational tools that can implement these methods (element E), and expert systems that deploy the prediction models (element F). Due to the nature of this expanding field, this study cannot provide an exhaustive overview of all the seven in silico components mentioned above. Prediction of Toxicity-associated properties of new chemicals is a big challenge. In admetSAR, probabilistic, regression as well as qualitative classification models were implemented for 'Human Ether-a-go-go-Related Gene Inhibition', 'AMES Toxicity', Carcinogenecity', 'Fish Toxicity', 'Tetrahymena Pyriformis Toxicity', 'Honey Bee Toxicity'.Among all the synthesized Pyrimidine derivatives (P1 to P5) , Pyrimidine derivatives P4 and P5 shows lesser toxicity.

Synthesis of Silver Nanoparticles Using Methanolic Extract of Medicinal Plants (Senna alata and Senna hirsuta) and Analysis of Antibacterial Activity

D. Madankumar; S. Pari

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 1581-1594

Because of their environmental friendly nature and effectiveness cost wise, green
synthesis of nanomaterial’s from plant has become progressively popular. In this research, we
used methanol extracts from fresh leaves of Senna alata and Senna hirsuta medicinal plants to
synthesize silver (Ag) nanoparticles as bio reducing agents. This method allowed the synthesis of
nanoparticles supported by spectrophotometry Ultraviolet-visible, FTIR, SEM, TEM and XRD
research. UV-Vis spectra and visual observation showed that after treatment with Ag precursors,
the color of the fresh Senna alata and Senna hirsuta leaf extracts turned into light greenish and
brownish yellow, respectively. This screened antibacterial activity against five different bacteria,
viz. Bacillus subtilis, Enterococcus faecalis, Staphylococcus aureus, Klebsiella pneumoniae and
Escherichia coli with the use of Disc Diffusion method. Silver nanoparticles extracted from
Senna alata and Senna hirsuta leaf extracts, which inhibited B.subtilis (18 & 16), E.faecalis (19
& 14), S.aureus (20 & 14), K.pneumoniae (21& 16) and E.coli (17 and 15), size in mm. The
higher Inhibition zone occurs in K.pneumoniae and S.aureus follows. It has been shown that
inhibiting bacterial growth, the Methanol extracts of Senna alata leaves containing Ag
nanoparticles is comparable with chloramphenicol.

Disease resistance efficacy of macroalgae mediated silver nanoparticles and its prophylactic activity against Pseudomonas aeruginosa infection in Oreochromis mossambicus

Thanigaivel Sundaram; S. Srinivasan; M. Nandhini; P. Vishnupriya; M. L. Pavithra; Perolla Haripriya; Vickram Sundaram; Gulothungan Govindarajan; Nanmaran Rajendiran

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 5739-5745

Bacterial pathogens are major threat to the aquaculture industry and small scale aqua farming. The emergence of various virulence pathogens during the culturing period leads to mass mortality and influence the loss of aquaculture production. As a result it causes economic imbalance. This relies on the very importance position to serve the protein rich sources for human consumption. In order to improve the sustainable aquaculture production the biologically synthesized silver nanoparticles have been used as an alternative method for commercial antibiotics to control such pathogenic infection. Marine microalgae Caulerpa racemosa was used as a silver reducing agent in this study. This controls Pseudomonas aeruginosa infection in tilapia. The bioactive compounds present in the extracts showed potential antioxidant and antibacterial activities against P. aeruginosa infection. The formation of AgNPs was observed by the visualization of the colour change and further confirmed by the UV spectroscopy. It was characterised by Dynamic light scattering measurements (DLS). The antibacterial activity was tested against the fish pathogen. It was found to be effective.

Synthesis of New Reagents as a ligands and Study of (Investigation, Chromatographic Behavior, Solubility)

Dr. Fatimah A. Wannas; Nemah Sahib Mohammed Husien; Dr. Afaq Jaber Kadhium; Dr. Nagham Mahmood Aljamali

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 5266-5279

Formazane ligands are described by many chemical and physical properties that have increased their applications in several fields and therefore have been classified as reagents or ligands with donor or multi-sites. Multiple methods have been used to prepare aldamine and formazane reagents, including imination reactions, condensation, substitution, duplication, including the formation of the carbanion and the reaction of nitrogen in coupling reaction. It is followed by investigation of prepared ligands by various sources that improved all results in this paper via various spectral measurements in inorganic chemistry area like (Uv-Vis, FT.IR, H.NMR) - spectra, besides to other measurements in analytical area like: (solubility, chromatographic behavior, TLC –plate), besides to bio- assay as antibacterial compounds for determination of efficiency of inhibition and other chemical characterizations (melting points, Rf, …).