Online ISSN: 2515-8260

Keywords : pathogenesis


Comparative study of obesity between men and women: Review

Zainab khidhair hussain; Israa Hasan Ali

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 367-378

Obesity is disorder in a foremost nutritional health it’s developed with countries developing. Also is known as increasingin fat accumulation that lead toproblem in health, besidesmay coin one of the reasons lead toloss of life,the obesity not effect on adults just but effect onoffspringand juveniles. In some ofinhabitants the incidence of obesity is superior in female than in male; on the other hand, the variation degree of the between the genderdifferby country.Obesity is generally measured by body mass index and waist circumference, Obesity are classified according to body mass index into:Pre obesity sort 1 : (25 - 29.9) kg/m2, Obesity sort 2 : (30 - 34.9 kg/m2) and extreme obesity sort 3: (40 kg/m2) or greater. Obesity is described by a pathologic condition with augmented overall of cholesterol, triglycerides, LDL cholesterol while reduced of HDL levels.There are many hormones causes pathophysiology of fatness such as adipokines, gutcorrelated hormones and ghrelin, numerous studies have revealed that the association among fatness and the metabolic sickness such as Insulin resistance, activity of lipoprotein lipase in muscle reduction and free fatty acids increasing. Conclusion: Obesity and overweight different between men am women according to quality of life in different population and countries

STUDY OF EFFICIENCY OF ROSAСEA THERAPY DEPENDING ON TNF-α GENE RS1800629 POLYMORPHISM

Babajanov O.A; Arifov S.S .; Abzalova Sh.R .; Urinbaeva D.A .

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2365-2369

The results of the study of the distribution frequency of the genotypes of the
polymorphism of the rs1800629 TNF-α gene involved in the formation and clinical course
of rosacea are revealed, which allows us to predict the development, course of the disease
and to develop the optimal scheme for its prevention and treatment. We studied the
polymorphism of the rs1800629 TNF-α gene in rosacea patients and determined the
effectiveness of therapy depending on the severity and frequency distribution of genotypes

Treatment Strategies Of Cholera: A Review

Clara Basumatary; Rajinder Kaur; Sukhminderjit Kaur

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4889-4899

Cholera is a contagious diarrheal disease which spreads through contaminated food and water. It is caused by Gram negative bacterium Vibrio cholerae of the O1 or O139 serogroup. Cholera can potentially spread as epidemic or endemic. If undiagnosed and untreated at the earlier stages, it can result in dehydration and death. Different endeavors are made for the treatment of cholera. Oral rehydration therapy (ORT), use of antimicrobials and antibiotics, probiotics and vaccinations are amongst the various alternative modes of treatment that can be used to treat cholera depending upon the severity of the disease. Also, antibiotics like tetracycline, azithromycin and doxycycline can be used synergistically for the treatment of acute infection and intense dehydration. Researchers have also advocated the use of different vaccines including oral cholera vaccine. In this review, we have provided a brief overview of the cholera disease and its pathogenesis along with different treatment strategies that can be used to treat it or reduce its symptoms.

Modern Approaches To Vitiligo Treatment

Mukhabbatkhon Yokubova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 1005-1007

This article discusses modern approaches to treating vitiligo and lists the methods of treating vitiligo.It was used to treat vitiligo in 28 patients. Most of them enjoyed of clinical condition. The preparation was well tolerated and produced no adverse effects.

RESULTS OF MOLECULAR GENETIC ANALYSIS OF MTR AND MTRR GENES IN CHILDREN WITH AUTISM

Majidova Yakutkhan; Farangisbonu Doniyorova; Nargiza Ergasheva

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 1666-1672

Statistically significant association of allele G and hetero A/G,
homozygous genotype G/G polymorphism rs1801394 MTRR gene with risk of autism
development was revealed. The presence of allele A and genotype A/A polymorphism of the
rs1801394 MTRR gene reduces the risk of autism. Identification of allele G increased the
risk of autism by 1.4 times compared to the presence of allele A (95% CI = 0.68-2.93, df=1).
The presence of the allele G of MTR A2756G polymorphism correlates with an increased
risk of autism.