Online ISSN: 2515-8260

Keywords : folate cycle disorders


RESULTS OF MOLECULAR GENETIC ANALYSIS OF MTR AND MTRR GENES IN CHILDREN WITH AUTISM

Majidova Yakutkhan; Farangisbonu Doniyorova; Nargiza Ergasheva

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 1666-1672

Statistically significant association of allele G and hetero A/G,
homozygous genotype G/G polymorphism rs1801394 MTRR gene with risk of autism
development was revealed. The presence of allele A and genotype A/A polymorphism of the
rs1801394 MTRR gene reduces the risk of autism. Identification of allele G increased the
risk of autism by 1.4 times compared to the presence of allele A (95% CI = 0.68-2.93, df=1).
The presence of the allele G of MTR A2756G polymorphism correlates with an increased
risk of autism.