Online ISSN: 2515-8260

Keywords : Chronic periodontitis

C-reactive protein and periodontal disease – A Review

Mohana Kondapally; Ramesh KSV; NVS Sruthima; Gautami S Penmetsa; P. Mohan kumar; G. Meghana

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 5, Pages 1664-1670

C- reactive protein (CRP) is an acute phase protein observed in increased quantities in plasma during the infections and presence of any inflammation, which could be a further possible risk factor in systemic inflammatory diseases such as arthritis, diabetes mellitus, and obesity. CRP molecules help as a biological marker for the determination of the inflammatory process when obtained from the gingival crevicular fluid and there is association between periodontitis and CRP levels. These levels are found to be reduced after the non-surgical and surgical periodontal treatment. Therefore, the levels of CRP would play a major role in determination of the inflammatory process.

Comparative evaluation of efficacy of sub-gingivally delivered 2% indigenously prepared curcumin gel and 1% commercially available hexigel as an adjunct to scaling and root planing in chronic periodontitis patients : A split mouth randomized controlled clinical trial.

Anupama Desai; Harish Kumar; Roquaiya Nishat; Shivanand Aspalli; Nagappa. G; YAnand Kumar

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 5299-5312

Aim: To evaluate and compare the clinical efficacy of subgingivally delivered curcumin gel and hexigel as an adjunct to scaling and root planing in chronic periodontitis patients.
Materials and method:A total of 12 subjects of age 18-55years were randomly selected for the study from the Out Patient Department. A total of 36 sites with pocket depths ≥5 mm were chosen as a split mouth design at three different sites in the same patient. After scaling and root planning, in Group I -2% curcumin gel, in Group II- Chlorhexidinegel(Hexigel ) and in Group III-placebo gel (control)was placed sub-gingivally. Clinical parameters such as gingival index and plaque index were recorded at baseline, 7 days and 21 days. Pocket depth was checked at baseline, 21 and 45 days.
Results:All the groups showed statistically significant reduction in gingival, plaque indices and pocket depth. Group I(curcumin)as a local delivery agent showedcomparable results in terms of pocket depth reduction as group II (Hexigel).
Conclusion:Curcumin gel showed effective results and thus, can be used as an alternate to chlorhexidine gel in management of chronic periodontitis patient without any side effects


Alisher Norbutaev; Jasur Rizaev; Jakhongir Abduvakilov; Nargiza Ortikova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 1680-1687

Abstract. The results of the effect of complex treatment on periodontal
microcirculation in patients with chronic periodontitis occurring with an iron deficiency
Purpose of the study: to study periodontal microcirculation in patients with chronic
periodontitis occurring against the background of iron deficiency states.
Materials and methods: As the research sources, 100 patients who applied to the
Samarkand regional dental clinic suffering from chronic periodontitis and iron deficiency
were selected. The patients were divided into 2 groups, of which 1 main group consisted of
50 patients who received glycodent gel and an iron preparation (combined iron (II) sulfate
- sorbifer durules / ascorbic acid). The second group received the generally accepted
standard therapy for chronic periodontitis. The diagnosis of iron deficiency states was
established by determining the parameters of iron and ferritin in the blood.
Microcirculation was studied using the "Lazma" apparatus (Russia).
Results and discussion: A positive effect on microcirculation of the complex of
treatment with glycodent gel and an antianemic drug for chronic periodontitis with an iron
deficiency state was revealed.


Subasree .Soundarajan; Sankari Malaippan; Priyalochana Gajendran

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1933-1942

The aim of the study was to investigate the association between haemoglobin level & severity of chronic periodontitis. This retrospective study was carried out by analysing the patient records from June 2019 to March 2020 at Saveetha Institute of Medical & Technical sciences (SIMATS).Two forty four patients were included in the study. Parameters assessed were a)Demographic details – Patient name, Patient identity number, Age & Sex; b)Periodontal parameters – Probing pocket depth (PDD), Loss of attachment (LOA), Bleeding on probing (BOP), Severity of Periodontitis (mild, moderate & severe);c) Blood parameters - Haemoglobin levels (g/dl). Data was analysed using SPSS version 23.0. Bivariate Pearson correlation of Haemoglobin with mean PPD, mean LOA & mean BOP score were calculated. Mean Hb was compared with severity of periodontitis using ANOVA. A total of 244 patients were included in the study. The mean age of the study sample was 40.42 (±11.38). Females constituted about 58.06%, whereas males constituted 41.4% of the study sample. Majority of the population had severe periodontitis (64.76%), followed by mild periodontitis (18.03%) & moderate periodontitis (17.21%). The mean haemoglobin level in severe periodontitis (13.35g/dl) is higher when compared to moderate and mild periodontitis (13.30g/dl & 13.18g/dl respectively). Mean PPD was 5.24 mm, mean LOA was 4.6 mm & mean BOP score was 0.98. Association between mean CAL and mean haemoglobin levels was positive and statistically significant with a p value of 0.012. Mean Hb level was not significantly different with varying severity of periodontitis