European Journal of Molecular & Clinical Medicine

The purpose of this study was to measure certain hematological parameters (Hb, PCV, and WBC counts), as well as the levels of malondialdehyde (MDA), glutathione (GSH), and insulin-like growth factor-1 (IFG-1). The study was carried out on blood samples from patients with thalassemia from the beginning of November 2021 to the end of March 2022. The study employed a total of (45) samples from the city of Tikrit city and (18) samples from a control group of healthy individuals. The age range for both groups was (15–17), The results showed that there were significant increase  at (P≤ 0.05) in the levels of (Hb, PCV and WBCs count) in patients group  which are (12.66±3.54 a) g/dl, (16.89±4.08 a) , (13.2±3.74 a ) respectively and control group were (8.59±2.84 b) g/dl ,(10.24±3.52 b) and (11.37±3.66 b) respectively ,the results also showed a significance increase (P≤ 0.05) in levels of IGF-1 in patients group which are (7.832±2.33 a) ng/ml and (2.181±0.72 b) ng/ml in control group, the study revealed that there was a significance decrease(P≤ 0.05) in levels of (MDA and GSH) in patients group which are (1.203±0.32 b)m mol/L ,( (0.0186±0.007 b)m mol/L and (2.671±0. 512  a) m mol/L and (0.0402±0.010 a) m mol/L in control group respectively

Background: Lichen planus (LP) is a common disorder whose etiopathogenesis is not clear.Recently, it has been suggested that increased reactive oxygen species (ROS) play important roles in the underlying mechanism of LP. Free radicals have an important involvement in the underlying mechanism of lichen planus and also various skin diseases. The aim of the study was to evaluate serum uric acid (UA) levels as a measure of the antioxidant defense status in lichen planus patients.
Methods: A case control study was performed on 17 patients with lichen planus and 17 healthy subjects as a control group. We estimated Serum level of uric acid and ascorbic acid using ELISA.
Results: The mean of serum levels of uric acid and ascorbic acid was lower in patient group compared to healthy group with no significant difference between the two studied groups.
Conclusion: Lichen planus pathogens are not specifically affected by antioxidants as uric acid and ascorbic acid. However, in addition to other interactive variables, the difference in the level of serum for these anti-oxidants between lichen planus patients and healthy subjectsalbight not important– may suggest their involvement.

The rising prevalence of many diseases is a growing concern in worldwide. Antioxidants are substances that prevent oxidation of other compounds or neutralize free radicals. Spices and herbs are rich sources of antioxidants. They have been used in many areas like food and beverages to improve its flavor, aroma and color. Due to their excellent antioxidant activity, spices and herbs have also been used to treat some diseases. This review focuses on the association between antioxidants and therapeutic approaches that may be the key to their use as potential remedy to treat various diseases. The antioxidant properties of some species and its importance in medicine to treat several diseases and its chemical compositions were discussed and summarized. The antioxidants play a major role in the area of medicine in next generation. This might be a novel approach in the field of medicine to treat various diseases and disorders.

The current study aimed to show the Pharmacological effect of Panax ginseng against oxidative stress that induced by shigella in rats. 24 rats (wt 200-250 gm with age4-6 month) were used in current work and divide as follow; Control group: male rats received standard diet. Infected group: administrated with 1 x 109 S. flexneri. Root extract group: administrated with root extract 150mg/kg for month. Treated group: administrated with 1 x 109 S. flexneri and treated with root extract 150mg/kg for month.The results demonstrated significant (P < 0.05) increased in levels of malondialdehyde (MDA) with significant (P < 0.05) decreased in levels of glutathione (GSH) and catalase in an infected group compared with control group. The findings of Root extract group and treated group demonstrated non-significant (P < 0.05) difference in oxidative status compare with control group when using C. azarolus extract. It was concluded from present study that Panax ginseng extract has been role against S. flexneri.

The study aimed to find out the effect of type II diabetes on fucose and some values of antioxidants compared to healthy people, as 30 blood samples were collected from patients with type II diabetes, their ages ranged from 30-55 years, while 20 blood samples were collected from healthy people of the same age group and for both sexes., Where the fucose level was measured, a significant increase was found in the patient group by 0.01 compared to healthy people, and the efficacy of the enzyme catalase was measured, and a significant decrease was found at the probability level of 0.05. Also, glutathione recorded a decrease of 0.01 in patients with diabetes mellitus compared to healthy people, while vitamin C, Malondialdehyde and Peroxynitrite were recorded. An increase in the patient group compared to the healthy group at the 0.01 level. While vitamin A and Glutathione-S-transferase were increased in the group of patients compared to the healthy group, with the probability level 0.05. The study also included the measurement of urea, creatinine, uric acid and basic phosphatase. Urea, creatinine, and basic phosphatase all recorded an increase in the group of people with type II diabetes at a probability level of 0.01 compared to the healthy group, while uric acid recorded a significant decrease at the probability level 0.01. compared to healthy controls

Oral squamous cell carcinoma (OSCC) is the most well-known malignant growth of the head and neck. It represents over 90% of all malignancies which happen in the head and neck region. The high frequency and mortality rate of oral cancer energizing continuation of exploration on finding new indicative diagnostic tools or markers for it. Oral squamous cell carcinoma (OSCC) is the 6th most common threat in the world. It is brought about by an assortment of elements, among which, oxidants, the results of typical digestion, rank high as a significant culprit in the development of the disease

Hindered phenolics are the compounds which will act as an antioxidant compared to the general phenolic compounds. Especially BHT compounds are shown here and which modifications will be responsible for the enhancing and reducing the efficacy of the phenolic compounds. These moieties are easily avaliable materials which found mostly in the foods, fruits and vegetables and also in several suppliments. The free radical oxidation of organic substrates is inhibited by phenols.and also involved in recovering from several pathophysiological conditions.In this review mentioned the several phenolic compounds which exhibits the effect of scavenging free radicals in the several pathophysiological conditions and daily life processes.

Male reproductive organ and other assessory sex glands plays an massive role in sperm production process, sperm maturation process, maintaining the entry of sperm cells in the female reproductive tract and until child birth. Many events could happen properly from semen ejaculation until it reaches the oozyte for proper fertilization. Any problem during the process of semen reaching female reproductive tract could men responsible. Overall 20 to 35 % of men contribute to the infertility. Clinical evidence suggests that tissue engineering and regenerative medicine could help men achieve the fertility status. Congenital abnormalities, iatrogenic injuries, trauma and other chronic conditions could be treated by regenerative medicine. Recently stem cell therapy has been emerging in the file of male infertility treatment regimes. In case of trauma, penile reconstruction, testes reconstruction available as most advanced treatment regime. Here we summarized the important findings and functions of testes, penile and scrotum reconstruction techniques, organ based regeneration for various male infertile disorders. Non-obstructive azoospermia conditions will be very tough to diagnose and this review comprises the important treatment regimes available for non-obstructive azoospermia. Antioxidants therapy, trace elements therapy, oral administration of carnitines and its potential applications were carefully elucidated for idiopathic conditions. We also summarized the role of prebiotics and probiotics as treatment regime for male infertility. All advanced treatments methods available were in general summarized in this review.