Online ISSN: 2515-8260

Keywords : cardiomyopathy

Assessment of relationship between serum uric acid and ejection fraction of the left ventricle

Dany John, Abhijeet Shelke, Aniket Avhad

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 4688-4692

Background: It has been proved that the prevalence of reduced ejection fraction heart failure (refHF) is decreasing, with a stabilization of mid-range ejection fraction heart failure (mrHF) prevalence and rise in number of patients with preserved ejection heart failure. The present study was conducted to assess relationship between serum uric acid and ejection fraction of the left ventricle.
Materials & Methods: 48 patients of chronic heart failure of both gendersunderwent cardiac ultrasound. Measurement of planimetric ejection fractions and left atrial volume were taken. Patients were divided into 3 groups based on ejection fraction. Group I had EF >50%, group II between 40-49% and group III had <40%. 5 ml venous blood samples were taken, and measurements of biochemical parameters such as serum electrolytes (Na+ and K+), serum creatinine (SC), and a lipid panel and serum uric acid (SUA) were performed. SUA was measured. NT-proBNP levels were also measured for all patients.
Results: Out of 48 patients, males were 30 and females were 18. The mean Na+ (mmol/L) was 139.2, 139.4 and 139.1, K+ (mmol/L) was 4.5, 4.7 and 4.9, S. creatinine (mg/dL) was 1.5, 1.6 and 1.9, eGFR (MDRD) (mL/min) was 46.7, 42.3 and 42.1, S. uric acid (mg/dL) was 7.9, 7.1 and 7.5, NT-proBNP was 2456.3, 3654.3 and 6714.5 and LAV (mL) was 64.2, 81.4 and 103.5 in group I, group II and group III respectively. The difference was significant (P< 0.05).
Conclusion: There was association of increased serum uric acid with the level of the ejection fraction of the left ventricle.


Akhmedova D.I.; Akhmedova N.R.; Ruzmatova D.M.; Danilova E.A.; Khusniddinova S.Kh.

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 1813-1823

Abstract. The study aimed to study the content of toxic and essential microelements in
the hair of children with cardiomyopathy living in areas with different climatic and
geographical conditions. 96 hair samples of children with cardiomyopathy living in different
environmental conditions were examined. The research results showed that the problem of
microelements is typical not only for the Aral Sea region but also for other regions: deficit
and/or deficiency of 2 or more vital microelements is found in 96% of children with CMP. The
frequency of trace elements in children in all regions was high in Ca, Cr, Co, Cu, He and Zn.
Children living in the Aral Sea region were characterized by excessive levels of manganese,
bromine, and iodine; children living in relatively advantaged regions were characterized by
reliably high levels of potassium, chlorine, and iodine.


D.I. Akhmedova .; N.R. Akhmedova .; D.M. Ruzmatova .; S.B. Akhmedova .

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2747-2755

Cardiomyopathy is a severe pathology, which requires careful
study of clinical parameters and data of functional diagnostics methods (ECG,
ECHO) for early detection. The study aimed to study the role of clinical and
instrumental, biochemical, and immunological investigation methods for early
detection and prognosis of cardiomyopathy course in children. Materials and
methods of study: 85 children with cardiomyopathy under 18 years of age were
examined, including 60 children with dilated cardiomyopathy (DCMP), 16
children with hypertrophic cardiomyopathy (HCMP) and 9 children with
restriction cardiomyopathy (RCMP) who were hospitalized in the
cardioreumatology department of the Republican Specialized Scientific-
Practical Medical Center of Pediatrics of the Ministry of Health of the Republic
of Uzbekistan. The control group consisted of 30 practically healthy children.