Online ISSN: 2515-8260

Keywords : Serum ferritin


Serum ferritin and liver function test response to oral versus subcutaneous iron chelating agent

Aymen Abd. Albakaa; Faris M. Al- Haris; Alaa Jumaah Mnaji Nasrawi; Jassim Mohammed Al Musawi; Talib Abdul Jalil Al Madany

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 10, Pages 130-135

Thalassemias are group of inherited autosomal recessive blood disorder. The genetic defect, which could be either mutation or deletion, results in complete absence or reduction synthesis of one of the globin chain that make up hemoglobin. This cause reduction of haemoglobin molecules production ,resulting in decreased of oxygen carrying capacity of the circulation thus causing anemia, the characteristic presenting symptom of the thalassemia. Good chelation therapy and regular blood transfusion protocol have increased the life expectancy.
Objectives : is to compare serum ferritin level and liver function test in a group of patients with beta thalassemia major in response to subcutaneous and oral chelating agent .
Patients and Methods: Prospective analytic study design done on group of 60 patients with beta thalassemia major diagnosed by hemoglobin electrophoresis registered in thalassemia center in AL – Zahra Teaching Hospital for Maternity and Children in AL- Najaf AL- Ashraf , during a period from
1st of February 2019 to 1st of February 2020, aged 2.5 to 17.9 years with serum ferritin levels above 1000 ng/ml and liver transaminases below 5 folds the normal upper limit .
The patients divided into 2 groups, 30 patients were on Deferasirox {Exjade} therapy and 30 patients were on Deferoxamine {Desferal} therapy .
Base line S. Ferritin value as well as LFT (S. GOT , S. GPT , ALP and TSB) value, were taken as base line level and then every (8-12) weeks and were used to assess the changes that occurred in response to subcutaneous and oral chelating agent .
Results : Our study show significant decline in SF (P value <0.05) in both groups after 1 year of treatment with oral or subcutaneous chelating agent. Patients on Exjade show more rate of decrement of serum ferritin (11%) compared to patients taken Desferal who a rate of decrement (6%). Patients on Exjade and Desferal therapy show increment in liver enzymes after 1 year of treatment with statistically significant results, p-value < 0.05 .
Conclusions
We found superiority in oral iron chelating agents (Exjade) to subcutaneous iron chelating agents (Desferal). Serum ferritin level is suitable for long term monitoring as an indicator of efficacy than liver biopsy .

Neurophysiological Assessment And Cognition In Adult Females With Iron Deficiency Anaemia

Dr. Umme Kulsoom Sheema; Dr. Alka Rawekar

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 1923-1925

Abstract: Background: Iron deficiency anemia (IDA) is the most prevalent form of anemia
especially in developing countries. Females of child bearing age are vulnerable for developing
IDA due to menstrual blood loss, dietary deficiency, pregnancy and lactation. IDA is
diagnosed by low blood hemoglobin and serum ferritin levels which correlates with body iron
stores. Of the various biological effects of iron, there are many evidences that iron effects
normal neurological functioning and development. This forms the biological basis for the
behavioral and cognitive developmental delays observed in iron-deficient anemic infants and
children. Reduced levels of blood hemoglobin and serum ferritin has been positively correlated
with low cognitive score and altered evoked potentials in females with IDA. Lack of research
studies to know the effect of IDA on neurophysiological parameters like cognitive
performance, event related potential and brainstem auditory response are little explored in
Indian adult females.
Methods: Cognitive status is assessed using Montreal Cognitive Assessment (MoCA) scale
which is validated testing scale for diagnosis of Mild Cognitive Impairment and
neurophysiological assessment is done using auditory Event Related Potential (ERP / P300)
and Brainstem Evoked Response Audiometry (BERA). MoCA score, ERP and BERA values
will be compared in females with iron deficiency anemia and normal females and also
associated with blood hemoglobin and serum ferritin levels. IDA may impair Cognitive
performance and hearing in adult females which may have tremendous impact on
understanding of speech and problem solving in them.
Hence, the aim of the study is to confirm a relationship between IDA and neuro-cognitive
features using cognitive scale and evoked potentials in adult females.

"Evaluation of Effect Of Dietary Advice Along With New Complete Dentures On Nutritional Status In Edentulous Patients"- An In Vivo Study

DR.PRAGATI GOYAL; DR. MITHILESH DHAMANDE

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 2099-2103

Background: The relationship between the oral health and nutritional status in the elderly is complex and controversial. It has been suggested that poor oral health and a decreased ability to chew have a profound influence on food selection, diet and thereby the nutritional status of the individual. Edentulous individuals consume diet that is lower in fruits, vegetables, protein and fiber as compared to dentate individuals due to decrease in ability to chew. If or not a combination of dietary advice along with prosthetic rehabilitation improves dietary intake is still not very clear. So, we are aimed to give dietary advice along with prosthetic treatment and thought of evaluating their nutritional status through OHIP-EDENT, Mini Nutritional Assessment test and serum ferritin levels at baseline, 6 months and 12 months.
Method/Outcome: A type of observational study in which 25 patients will be recruited after seeing into the inclusion and exclusion criteria and then these patients will be given complete denture prosthesis along with nutritional advice and the outcome will be assessed using OHIP-EDENT, Mini Nutritional Assessment Test and Serum Ferritin levels at baseline six and nine months. Expected Results: Simple dietary advice that can be implemented by a dentist would be more practical in clinical practice than tailored dietary counselling. So, giving simple nutritional advice in combination with new complete denture would improve nutrient intake among edentulous individuals