Online ISSN: 2515-8260

Keywords : Hyperbilirubinemia

Cord blood albumin as a predictor of significant neonatal hyperbilirubinemia in normal term healthy newborn

Dr. Dharmagadda Sai Krishna, Dr. Hemant Gupta, Dr. Neelam Grover, Dr. Bharti Kawatra, Dr. Kiranjeet Kaur

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 18-24

Introduction: Hyperbilirubinemia is the most common morbidity in normal term healthy
newborn. There is evidence that cord blood albumin (CBA) level can act as a potential marker
for the prediction of hyperbilirubinemia in neonates. The present study was therefore designed
to establish a correlation between the level of cord blood albumin (CBA) and total serum
bilirubin (TSB) so that albumin level could be standardized as a prediction marker for the
neonatal hyperbilirubinemia.
Methods: CBA and TSB levels were analysed in 500 normal term healthy newborns with birth
weight ≥2500 grams and APGAR score ≥ 7/10 at 1 min and 5 mins, after obtaining consent
from their parents. Albumin levels were analysed from the cord blood at the time of birth and
TSB levels were analysed from venous blood. Pearson’s correlation coefficient was used to
analyse the correlation between CBA and TSB levels.
Results: The mean CBA was 2.94 ± 0.34 g/dl and mean TSB was 11.17 ± 2.52 mg/dl. The
relationship between CBA and TSB values was statistically significant on further analysis of
CBA with the modality of treatment, the results were again statistically significant. The
correlation between CBA and TSB was also observed with negative correlation of r = - 0.43
with p value of <0.0001 which was highly significant.
Conclusion: Newborns with high CBA levels have low risk of developing neonatal
hyperbilirubinemia and can be discharged early from hospital. Whereas low CBA is an
indicator for developing neonatal hyperbilirubinemia in the first week of life.

“Is there any effect of Phototherapy on Cardiac Function in Neonates with Hyperbilirubinemia”

Dr. Amar Taksande; Dr. Jayant Vagha; A. Rupesh Rao

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 1967-1976

Abstract: Background- Neonatal jaundice is commonly seen in preterm new born and
phototherapy treatment of choice when indicate. Phototherapy is an efficient treatment
although there is some side effect present. These side effect may be on behavioural and
physiological in some organ and there is also changes in stages of sleep cycle and
circadian rhythm during and after phototherapy for few days. These changes in sleep cycle
due to the neurotransmitter tryptophan and there is also changes is hormones like
decreased in the growth hormones and there is changes in the melatonin which may affect
with sleep cycle. there is some study done which suggestive that phototherapy will affect the
stages of sleep but there is solid information available whether there is any effect of
phototherapy on cardiorespiratory activity. Some old study is suggestive of there is
increased in heart rate and decreased in the SBP systolic blood pressure during
phototherapy. Phototherapy cause to increase the respiratory rate and heart rate during
phototherapy. Objectives: To determine the outcome of phototherapy after 24hrs, 48hrs,
72hrs, and >72hrs on cardiac function in term neonates with hyperbilirubinemia. Results-
After completion of the study we will come to know the effect of phototherapy on cardiac
function and also get the idea for how many hours ( <24hrs / 48hrs. 72hrs or > 72hrs) we
can give safe phototherapy to the neonate with hyperbilirubinemia without affecting the
cardiac function. Or is there any need for cardiac shielding during phototherapy.
Conclusion- After completion of the study we will come to know the effect of phototherapy
on cardiac function in term neonate who is having neonatal hyperbilirubinemia.