European Journal of Molecular & Clinical Medicine

Background: An important well-known event of respiratory failure (RF) is frequently associated with severe exacerbations of chronic obstructive pulmonary disease (COPD). Moreover, the hypercapnia presents during an acute episode of RF, which is found to have higher mortality rate.
Objectives: To investigate the role of NIV applied to COPD patients with acute HRF who presents with acute exacerbations and require hospitalization.
blood gases (ABG) data from patient at baseline, i.e., at arrival (0hr) and follow up Material and Methods: This study was a prospective, observational study which was carried out at Apollo Gleneagles Hospital, Kolkata during the period of study was 18 months (from January 2019 to June 2020). A total of 90 patients were recruited in the study. All COPD cases presenting in the Emergency Department during morning shift for arterial at the time interval of 2 and 12hrs and patients presenting with Acute Exacerbations of COPD were included in the study.
Results: A total of 90 patients were admitted to the emergency department of Apollo Gleneagles hospital due to AECOPD presenting with HRF, was evaluated and treated with NIV for a better outcome concerning ABG parameters. The maximum value (27.80%) was obtained for the age groups of 51-60 years followed by age groups of 61-70 years (21.10%) and a minimum frequency value (3.30%) was observed for the age groups of 91-100 years. The mean ± standard deviation of age value was 66.37 ± 13.64 years. The data on the distribution of ICU admission (% frequency), a maximum value showing ICU as NO groups (55.4%), and a minimum value of about ( 44.6%) of YES groups as ICU admission were obtained among total studied patients. Overall hospital duration revealed that the minimum duration of hospitalization of 1 day and maximum value of 14 days were recorded and the mean ± standard deviation of the duration of hospitalization value was 4.59 ± 3.31 days.
Conclusion: In the present study, patients present in the age groups of 51-60 years were observed more susceptible and management through NIV was found to be more beneficial. Moreover, the duration of hospital stays, and ICU admission were found to have reduced in number after NIV treatment.

Background: An important well-known event of respiratory failure (RF) is frequently associated with severe exacerbations of chronic obstructive pulmonary disease (COPD). Moreover, the hypercapnia presents during an acute episode of RF, which is found to have higher mortality rate. Objectives: To investigate the role of NIV applied to COPD patients with acute HRF who presents with acute exacerbations and require hospitalization. Material and Methods: This study was a prospective, observational study which was carried out at Apollo Gleneagles Hospital, Kolkata during the period of study was 18 months (from January 2019 to June 2020). A total of 90 patients were recruited in the study. All COPD cases presenting in the Emergency Department during morning shift for arterial blood gases (ABG) data from patient at baseline, i.e., at arrival (0hr) and follow up at the time interval of 2 and 12hrs and patients presenting with Acute Exacerbations of COPD were included in the study. Results: A total of 90 patients were admitted to the emergency department of Apollo Gleneagles hospital due to AECOPD presenting with HRF, was evaluated and treated with NIV for a better outcome concerning ABG parameters. The maximum value (27.80%) was obtained for the age groups of 51-60 years followed by age groups of 61-70 years (21.10%) and a minimum frequency value (3.30%) was observed for the age groups of 91-100 years. The mean ± standard deviation of age value was 66.37 ± 13.64 years. The data on the distribution of ICU admission (% frequency), a maximum value showing ICU as NO groups (55.4%), and a minimum value of about ( 44.6%) of YES groups as ICU admission were obtained among total studied patients. Overall hospital duration revealed that the minimum duration of hospitalization of 1 day and maximum value of 14 days were recorded and the mean ± standard deviation of the duration of hospitalization value was 4.59 ± 3.31 days. Conclusion: In the present study, patients present in the age groups of 51-60 years were observed more susceptible and management through NIV was found to be more beneficial. Moreover, the duration of hospital stays, and ICU admission were found to have reduced in number after NIV treatment.

Background: Alveolar cleft closure is vital in achieving stability of maxillary arch, providing a foundation for alar base, prevent the inferior turbinate from herniating into cleft area and giving impetus to teeth adjoining cleft. Intact Soft tissue cover over the grafted cleft site will provide a contained cavity which will help maintain the grafted bone in the compacted position till new bone formation occurs. Customized surgical splint over the operated site as a mechanical barrier can help improve the soft tissue healing in patients undergoing Alveolar bone grafting (ABG).
Aim: To compare the utility of customized surgical splint in terms of soft tissue healing overlying the grafted alveolar bone
Material and Methods: Random allocation of unilateral cleft alveolus patients in two groups will be done. Group A, in which immediately after the surgery in a customized surgical splint will be placed. Group B, in which no splint will be given. Soft tissue healing will be assessed for both the groups on post-operative day 7^th and 15^th.
Result: Results will be analyzed using Student’s paired t-test. It is expected that the soft tissue healing will be significantly better in the patients with surgical splints.
Conclusion: Expected results of better soft tissue healing with utilization of customized surgical splints in operated patients of cleft alveolus may be recommended as part of standard care protocol. It can play a pivotal role in subsequent successful uptake of graft by improving soft tissue healing