Online ISSN: 2515-8260

Keywords : Periostin

Serum Periostin Level Interpretation in Asthmatic Children

Shimaa Khaled Ismail, Mohamed Sanad Nagiub, Heba Gamal Anany, Ayman Abdel Rahman Allam

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 4444-4451

Background: Asthma is a major public health problem that affects nearly 350 million people worldwide. It is also the most common chronic disease in childhood and adolescence.Several asthma phenotypes and endotypes have been identified. While 80% of children with asthma have allergies.In recent years, studies on the role of periostin in asthma have been published.Periostin is a cell matrix protein that was first identifid in mouse periodontal ligament. It is secreted by bronchial fibroblasts and epithelial cells, acts as an immunomodulator, repairs connective tissue, and is involved in fibrogenesis. Significant periostin expression has been noted in the bronchial epithelial cells of children with asthma.

Assessment and comparison of Periostin levels in peri-implant sulcular fluid as a biomarker in healthy peri-implant sites and sites with periimplant mucositis and peri-implantitis

Dr. Anup U Shelke; Dr. Prasad V Dhadse

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2009-2016

Abstract: Background – Peri-implant diseases need early diagnosis and intervention in order
to prevent implant failure. Periostin is an enzyme imperative for periodontal health which
decreases with increasing severity of inflammation and levels revert back to normal after
treatment. Alterations in the levels of periostin with relation to peri-implant diseases is not yet
been investigated. This study aims to explore the role of periostin in peri-implant health and
disease. Objectives: To evaluate and compare the levels of Periostin in peri implant sulcular
fluid (PISF) in healthy peri-implant sites and sites with peri-implant mucositis and periimplantitis
with its clinical correlation. Method and design: Total of 66 implant sites loaded at
least one year earlier will be included in this study and divided into three groups. Group I
(healthy peri-implant tissues), group II (peri-implant mucositis), and group III (periimplantitis).
Levels of periostin in peri-implant sulcus fluid (PISF) acquired by microcapillary
pipettes acquired by micro-capillary pipettes will be determined from each group
using human periostin ELISA kit. Results: The results will be analyzed as levels of periostin in
peri-implant sulcular fluid recorded by ELISA in all the three groups and will be subjected to
intergroup comparison and will be presented after statistical analysis. Conclusion: Levels of
periostin in peri-implant sulcular fluid may prove to be a magnificent tool in early and prompt
diagnosis of peri-implant diseases which will help in planning and execution of appropriate
treatment, hence preventing further destruction of supporting tissues increasing longevity of
dental implants.