Online ISSN: 2515-8260

Keywords : Chitosan nanoparticles

“Evaluating Salivary pH, Uric acid, & CReactive Protein levels in Completely Edentulous patients before and after wearing Complete dentures incorporated with and without 7.5% Chitosan nanoparticles” – An Interventional Study


European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2132-2137

Abstract: Background: Saliva plays major part in oral well-being of complete denture
users and also considered a very important biomarker for overall body health and indicates
several biomolecules just like blood to give useful information and monitoring of diseases
and health .Denture stomatitis is a common finding in complete denture wearers and
analysing salivary ph, Uric acid & C-reactive protein levels through saliva collection will
help in its early diagnosis and treatment. Chitosan, a biomaterial nanoparticle
incorporated into dentures gives it antifungal and antimicrobial effect. Having
antimicrobial and regenerative properties it is of interest in dentistry and already being
used in toothpastes, mouth rinses and dental dressings.
Objectives: To evaluate salivary ph , Uric acid & C-Reactive protein levels before and after
complete denture insertion with and without addition of Chitosan nanoparticles &
Comparatively evaluate the outcome.
Method: 15 complete denture patients incorporated with Chitosan nanoparticles will be
tested for salivary ph, C-Reactive protein & Uric acid levels. Saliva samples will be
collected from subjects immediately before the insertion of complete dentures and after 24
hrs and compared with Control groups not containing Chitosan.
Results: This study shows antifungal and antimicrobial effect of Chitosan in Complete
dentures which implies less fungal activity post denture insertion leading to less denture
stomatitis cases proving effectiveness in preventing Denture stomatitis.