Online ISSN: 2515-8260

Keywords : Atrial Fibrillation

Aetiological and Clinical Study of Atrial Fibrillation :An Observational Study in a Tertiary Care Hospital ,Telangana ,India

Dr.Rajeev Kumar Togiti, Dr.Raj Kumar Goud ,Dr.D.Kiran, Dr.Sharanya Vootla

European Journal of Molecular & Clinical Medicine, 2023, Volume 10, Issue 1, Pages 4422-4432

Atrial fibrillation is the most common sustained arrhythmia seen in clinical practice. It is responsible for increased mortality from all cardiovascular causes and shortens average life span. Aims: To know the various clinical presentations in atrial fibrillation and to detect various aetiological factors of atrial fibrillation.Methodology: This Observational study was conducted on 50 cases of atrial fibrillation.Cases were examined in detail as per proforma with special reference to cardiovascular system.Investigations like urine examination, complete Blood picture, Erythrocytes Sedimentation rate, Blood urea, Serum creatinine, Blood sugar, Serum electrolytes and chest X-ray examination have been carried out. Special investigations like electrocardiogram, echocardiogram was also done. Whenever necessary blood for culture and sensitivity, CT-Brain in case of stroke. The electrocardiogram was studied for rate and ‘f’ wave pattern. The echocardiogram was studied to assess the valvular lesion, Mitral Valve Area (MVA) in mitral stenosis cases, and enlargement of chambers particularly the left atrium size.Results: Most of the chronic atrial fibrillation is associated with large left atrial size, 4-5cms (56%).Congestive cardiac failure (60%), angina (32%), embolic stroke (14%) are common complications.Incidence of congestive cardiac failure, angina are high in patients of chronic AF with fast ventricular rate.Incidence of embolic stroke is more in rheumatic AF.Incidence of embolic stroke is high in non-rheumatic AF with the presence of risk factors like age >65yrs, HTN, DM, CCF, LA size > 4.5 cm.Most of the cases of AF associated with MVA is less than 1 (Severe) in RHD.Conclusion: Atrial fibrillation due to rheumatic aetiology is more common in younger age group, while the other causes like hypertension, ischemic heart disease common in older age.Females are commonly affected than males.Rheumatic heart disease is commonest cause followed by ischemic heart disease, Hypertension.

Significance of LADi (Indexed Left Atrial Diameter) as a predictive marker for acute ischemic stroke

Dr Rakesh Chander, Dr Gagan Mittal, Dr Hiteshi Goyal, Dr Shivika Aggarwal, Dr Kashmir Singh

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 4079-4085

Aims: The present study was designed to assess LAD and LADi as a predictive marker for Acute Ischemic Stroke and to analyse their association in patients with AF in Acute Ischemic Stroke patients.
Materials & methods: This study was conducted on 50 patients with acute ischemic stroke and 50 patients without stroke who attended outdoor department or who were admitted in Medicine Department of Guru Nanak Dev Hospital, attached to Government Medical College, Amritsar. The patients were divided into two groups (Group A and B) as follows: Group A includes 50 Patients with acute ischemic stroke, and Group B includes Age and sex matched 50 patients without stroke. Left atrial diameter (LAD) was measured using Two-dimensional echocardiography from the posterior aortic wall to the posterior left atrial wall according to a leading edge to leading edge convention in the parasternal long-axis view at the end-ventricular systole (i.e., just before the mitral valve opening). Indexed left atrial diameter (LADi) was calculated by dividing Left atrial diameter with body surface area (BSA). The data was collected systematically and analysed using Microsoft excel sheet and statistical package for social science version 21.0 (SPSS, Chicago, IL, USA).
Results:In group A, the mean left atrial diameter was 4.02 cm and in group B, the mean left atrial diameter was 3.44 cm. The mean LADi was 2.30 cm/m2 and 1.98 cm/m2 in Group A and Group B respectively. The mean LADi was higher in group A as compared to Group B and the difference was significant statistically (p<0.0001). In addition, among 23 ischemic stroke patients who were having AF, 21.7% had normal LAD and 78.3% had increased LAD. Among 27 control patients who did not have AF, 63% had normal LAD and 37% had increased LAD. The difference was statistically significant (p=0.03). In group A patients in whom AF was absent, 48.1% had normal LADi and 51.9% had increased LADi. In group B patients in whom AF was absent, 84.6% had normal LADi and 15.4% had increased LADi. The difference was again statistically significant (p=0.002)

Interpretation of Epicardial Adipose Tissue Thicknessand Heart Disease in Atrial Fibrillation Patients

Mohamed Ahmed Abdalla Ebada, Aly Mohamed Abdelrahman, Ghada Ibrahim Mohamed, lam Galal Sayed

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 4474-4479

Background:Atrial fibrillation (AF) is commonly associated with overweight and obesity.
Overweight populations have higher incidence, prevalence, severity, and progression of AF
compared with their normal weight counterparts. Stable weight loss decreases AF burden and
AF recurrence following treatment.Epicardial adipose tissue (EAT) is a small but very
biologically active ectopic fat depot that surrounds the heart. Given its rapid metabolism,
thermogenic capacity, unique transcriptome, secretory profile, and simply measurability,
epicardial fat has drawn increasing attention among researchers attempting to elucidate its
putative role in health and cardiovascular diseases.


Botir Daminov; Sherzod Abdullaev; Ranokhon Igamberdieva

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2346-2352

Patients with Chronic Kidney Disease (CKD) develop a tendency to bleed and
thromboembolism, so the indication for anticoagulants at the attachment of atrial
fibrillation (AF) is complex. AF is the most common chronic heart arrhythmia, and
thromboembolism and ischemic stroke in particular are the main complications. In recent
years, new oral anticoagulants have been developed and they have shown superiority over
the classic antivitamin K anticoagulants in preventing the risk of stroke, systemic embolism
and bleeding, providing an effective alternative to these resources