Online ISSN: 2515-8260

Keywords : Cognitive function


Roshan Kumar Jha; Deepika Kanyal; Dr. Archana Dhok; Lata Kanyal Butola

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 1096-1109

Vitamin D is also known as calciferol because of its role in calcium metabolism and antirachitic factor because it prevents rickets. It is a modified steroid, synthesised in the skin under the influence of sunlight and is necessary for metabolism of calcium and phosphorus. Its RDA is 400 IU or 10 mg, it binds to the receptor of target cells and regulate through gene expression. Vitamin D undergoes hydroxylation in the liver to form 25 hydroxy vitamin D [25(OH) vitamin D]. The two main forms are vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). The main source of vitamin D in humans is in the form of vitamin D3, which is derived from synthesis in the skin via exposure of 7- dehydrocholesterol, concentrated in the stratum basale and stratum spinosum, to ultraviolet B (UV-B) radiation. Vitamin D2 is obtained from the diet, and is derived from ultraviolet irradiation of ergosterol, found in fungi. Both metabolites are transported in the blood bound to vitamin D binding protein (DBP). These inactive vitamin D metabolites must undergo a two-step hydroxylation process to become biologically active. Initially, vitamin D2 and D3 undergo hydroxylation in the maternal liver, via the action of vitamin D 25-hydroxylase enzyme (CYP27A1), to form the inactive steroid precursor 25-hydroxyvitamin D (25[OH]D). 25[OH]D is the major circulating and stored form of vitamin D. In this present review we have focused on need of vitamin D beyond bone.

Cerebrocardial syndrome, ways of full correction

D. T. Abdukadirova; U.T. Abdukadirov; Sh. M. Kobilov

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2359-2364

The purpose of the research: to determine the clinical effectiveness of complex
therapy with cholinealfoscerate drugs as a supplement to standard therapy in patients in
the acute period of ischemic stroke of hemisphere localization. Materials and methods:
Sixty patients with acute cerebral stroke were examined, with an average age of 56+_ to
4.38. The main methods of the study were the collection of complaints and history, analysis
of medical records, assessment of somatic and neurological status, paraclinical research
methods (MRI), study of cognitive functions. The examination of patients was carried out
during the acute period of stroke and repeated after 3 months. The results have been
processed statistically. Results.The study revealed that the use of drugs of the group
cholinealphoszerate in the acute phase of stroke and in the next 2 months has a beneficial
effect not only on the restoration of motor and sensitive neurological deficits, improved
cardiac activity, but also reduces the incidence of early post-stroke dementia (high
confidence) and reduces the severity of clinical manifestations of lung and moderate
cognitive disorders. Conclusions. For the comprehensive correction of the manifestations
of ACCD and the prevention of post-stroke dementia, as well as reducing the progression
of cognitive disorders, stroke patients should recommend the use of drugs
chodinoalfoscerat (Cerepro) (in a dose of 2000mg/day intravenous drip for 5 days, then
1000mg/day intravenous5 days, then 1 restorative tablet 2 times a day (800mg/day) - 2
months) from the first days of stroke and in the early period.

“Association of Cognitive function and Depression with Chronic exposure to Organophosphate pesticides in the Agricultural community of rural area of Wardha District.”

Dr. K. Himabindu Reddy; Dr. Vasant Wagh

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 2049-2056

vast majority of India’s population (58%), depends on agriculture for their livelihood and a vital part of our agricultural production technology constitutes of Pesticide use. According to a international report in 2013 " India is the largest producer of pesticides in Asia and ranks 12th worldwide for application of pesticides”. In India ,Maharashtra has been the biggest consumer of pesticides in the last 5 years
Indian agricultural community belongs to the unorganized sector; hence they receive quite little in terms of healthcare and social security. They thus are very vulnerable to loss of income and unavailability of healthcare, despite belonging to an occupation which involves numerous hazardous possibilities.
Chronic exposure to organophosphate pesticides is associated with a multitude of ill health outcomes including polyneuropathy, dermatitis, behavioral changes, glucose intolerance & cancer .The Nervous system in particular in more sensitive to the Organophosphate pesticides, so monitoring of chronically exposed people may help prevent the onset of future neurodegenerative diseases.
The aim of this study is to assess changes in levels of Acetyl cholinesterase levels due chronic pesticide exposure, evaluate cognitive function and depression among farmers 
chronically exposed to organophosphorus compounds, and determine the association between them.
Using standardized questionaries, data will be collected about personal habits, work practices, awareness of pesticide exposure adverse effects and among individuals living in area of study, involved in agriculture repeatedly in direct contact with pesticides. Blood samples to assess biomarker (cholinesterase) will be taken and cognitive function and depression assessment will be done using MMSE tool and PHQ-9 / Beck’s inventory.
Data collected over study period will be analyzed and appropriate statistical tests will be used to determine results and draw relevant conclusions.