Online ISSN: 2515-8260

Keywords : cardiovascular system


FEATURES OF DIAGNOSTICS OF CARDIOVASCULAR AUTONOMOUS NEUROPATHY OF CHILDREN WITH DIABETES MELLITUS TYPE 1

Dilfuza Ashurova; Azizakhon Sadirkhodjaeva; Malika Khaldarbekova; Zukhra , Shermatova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2382-2392

Abstract. The presence of cardiovascular autonomic neuropathy (CAN) significantly
worsens the prognosis and course of the underlying disease. So in patients with diabetes
mellitus (DM) and CAN, the mortality rate for 5 years is five times higher compared to
patients without this complication. Due to the fact that CAN is closely associated with
cardiovascular pathology, many authors consider CAN as a significant factor in
cardiovascular risk. Purpose. To establish clinical, functional and metabolic changes in
diabetic autonomic cardiovascular neuropathy in children with type 1 diabetes. Materials and
methods research. The total number of patients studied by us was 114 children with type 1
diabetes mellitus aged 4 to 18 years. We conducted laboratory and instrumental research
methods. Laboratory methods: general clinical research (general analysis of blood and urine,
studies of blood sugar), biochemical methods (total blood protein, bilirubin, cholesterol,
triglycerides, creatinine, urea, electrolytes, glycated hemoglobin), 24-hour heart rate
monitoring with circadian index estimation was used and parameters of time and frequency
analysis of heart rate variability. Conclusion diabetic autonomic cardiovascular neuropathy in
children with type 1 diabetes is characterized by the development of tachyarrhythmic rhythm
disturbances, as well as the formation of rigidity of the heart rhythm and a decrease in the
sensitivity of the sinus node to parasympathetic influences according to a temporary analysis
of daily monitoring of heart rhythm.

Clinico - Functional Features Of The Condition Of The Cardiovascular System In Newborn Children With Delay Of Innerabetal Development

Rakhmankulova Zukhra Jandarovna; Khodjamova Nargiza Karimovna; Ismailova Muazam Asrarovna; Gulyamova Muyassar Abdusattarovna; Tukhtaeva Umida Dilmurodovna

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3403-3416

Intrauterine growth retardation is an important problem in pediatrics, as it is an integral indicator of intrauterine dysfunction.
Purpose: to study the features of the clinical and functional state of the cardiovascular system in newborn children born with various types of intrauterine growth retardation.
Material and research methods: 70 newborns were examined. All children were divided into 2 groups: the 1st (main) amounted to 50 newborns with IUGR, of which: 1a - with the symmetric version of IUGR - 25, 1b - with the asymmetric version of IUGR - 25 children, in the 2nd group (comparisons) 20 premature infants without IUGR were included. All newborns underwent an echocardiographic examination of the heart.
Results: on the basis of clinical and instrumental studies, the features of the clinical and functional state of the cardiovascular system in newborn children born with various types of intrauterine growth retardation are presented. In children who had different types of intrauterine growth retardation, significantly significant features of cardiac activity and morphological and hemodynamic parameters of the heart at birth were proved. Children with a symmetric variant of IUGR are characterized by a slowed heart rhythm, which was recorded significantly more often than in children with a symmetric variant of IUGR.

Problematique Of Use Of The Crispr/Cas9 System To Create And Research Cellular Models Of Cardiovascular Inherited Human Diseases

Yumashev Alexei; Kamalova Dinara; Kulaeva Imani; Spaska Anastasiya

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 2849-2856

The genome editing technology has become a powerful method for creating genetically modified cells and organisms, necessary for the genes function and mechanisms of human disease determination. The clustered system with regularly interspaced short palindromic repeats (CRiSPR-), associated with9 (Cas9), quickly became one of the world’s major approaches to genome editing in basic biomedical research in recent years as a result of its simplicity and adaptability.
Genome editing CRiSPR/Cas9 werebeing used for correction mutating people's DNA from one base pair to large deletions both in vitro and in vivo. Model systems CRISPR/Cas9 are usedfor a better understanding of many aspects of cardiovascular disease, including lipid metabolic, electrophysiology and genetic heritage. CRiSPR/Cas9 technology has been proven to be effective for editing induced pluripotent stem cells. In spite of these gains, some biological, technical and ethical problems limit therapeutic capacity to edit the genome by cardiovascular diseases. The purpose of the study is to analyze the applications of CRiSPR/Cas9 genome editing in the cardiovascular system, for both disease research and treatment prospects by editing the genome in vivo in the future.

Anamnestic Data Of Patients With Hyperplastic Processes In The Endometrium

Zilola Nazirova; Diloramkhon Asrankulova; Gulnoza Akhmadjonova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 3382-3390

Endometrial hyperplasia (EH) is one of the main forms of pathological proliferative changes in the uterine mucosa, regardless of the age of women. Hyperplastic processes can occur independently or be combined with anotherpathology, appear against the background of many somatic and gynecological diseases. Result: In recent years, there has been an increase in endometrial hyperplastic processes, which is associated with an increase in the life expectancy of the female population, an unfavorable environmental situation, an increase in the number of chronic somatic diseases