Online ISSN: 2515-8260

Keywords : preeclampsia


DEVELOPMENT OF PRE-ECLAMPSIA IN PREGNANT WOMEN WITH OBESITY

Zulfiya Shamsieva; Yusupbaev R.B.

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2450-2454

Abstract. The aim of this study was to examine the impact of obesity in pregnant women in
the development of preeclampsia. All women were divided into 2 groups: the study group
included women with obesity (n=120) and the control group of pregnant women with
physiological course of pregnancy without obesity (n=60).

Correlation Of Risk Factors For Preeclampsia With Blood Pressure And Proteinuria

Hidayati Ratna; Hayati Farida; Fuadah Z. Dina; Sari K. Melani; Ludyanti L. Nita; Ishariani Linda

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 4710-4717

Background: Preeclampsia is related to the inability to adapt to the physiological changes of pregnancy that result in decreased maternal organ perfusion. This complex clinical syndrome in preeclampsia can affect all organ systems such as the hemodynamic system, kidney, retina, and blood chemistry, which is manifested by increased blood pressure and protein urine.
Purpose: This study aimed to determine the correlation of the factors causing preeclampsia with blood pressure and protein urine.
Methods: This correlational study using the 127 respondents, sampling purposive sampling techniques, the independent variable factor in preeclampsia (age, genetics, history of diabetes mellitus, history of hypertension), and the independent variable blood pressure and protein urine. The measuring instrument used is a sheet checklist and analyzed by Spearman rank.
Results: The results showed the risk of preeclampsia in the age factor of 40.9% occurred in the 28-35-year-old respondents; 100% of patients had no history/genetic preeclampsia, 100% of respondents did not have a history of diabetes mellitus, and 88.9% did not have a history of hypertension. Systole blood pressure increased moderately and high by 26.0% and 22.0%, while diastolic blood pressure increased moderately and high by 26.0% and 11.0%. Respondents had positive proteinuria of 52%. The results of the analysis are not found a significant correlation between the factors of age, genetics, history of diabetes, and history of hypertension with blood pressure and preeclampsia protein urine on respondents.
Conclusion: History of hypertension associated with blood pressure and proteinuria in preeclampsia. History of hypertension is related to the condition of the blood vessels that manifest hypertension and decreased renal function (protein urine). Therefore, it is recommended in women with a history of hypertension to control blood pressure and perform routine prenatal care during pregnancy to prevent further complications.

An individual approach to the management of gestational diabetes

Gulrux K. . Karimova; Nilufar O. Navruzova; Shahodat N. Nurilloyeva

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 6284-6291

Objective: Selection of an effective method of delivery for mother and child in pregnant women with gestational diabetes. The retrospective group included 67 women who passed through the regional perinatal center, city maternity complex and family clinics No. 5, No. 6 of the city of Bukhara in the periods from 2016 to 2018. The main (prospect) group consisted of 68 women whose pregnancy proceeded against the background of overt or gestational diabetes mellitus (GDM). The control group consisted of 36 women whose pregnancy proceeded physiologically. As a result of the study, the course of pregnancy and childbirth according to the history of childbirth and own observations revealed that in all (60%) pregnant women with GDM, pregnancy and childbirth proceeded with any complications, like in the mother and the fetus. Thus, pregnancy proceeded against the background of corrected diabetes with the use of the optimal insulin regimen and rational diet therapy, the absence of signs of diabetic fetopathy, then in this category of pregnant women, the delivery through the birth canal is considered the best option.

The Differences Of Infant Outcome In Mothers With Severe Preeclampsia, Preeclampsia With Complication, And Normal Pregnant Women

Deviserlina Babys; Irfan Idris; Prihantono .

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 6889-6893

The results showed that there were differences in gestational age (p = 0.000), APGAR score (p = 0.000), birth weight (p = 0.001), birth length (p = 0.000) in severe preeclampsia, severe preeclampsia with complications, and maternal. pregnant normally. The results of this analysis indicate that infant outcomes are worse in mothers with preeclampsia.

Histomorphological Changes In Hypertensive Placentas And Its Correlation With Foetal Outcome

Dr. Geetanjali U. Yadgire; Dr. Shobha S. Rawlani; Dr. Anupama Sawal; Dr. Deepali G. Vidhale

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 1938-1947

Placenta is an important organ which is necessary for the intrauterine growth of foetus.complications .due to Pregnancy like hypertension(PIH) affects the placenta and is the major factor to cause maternal & foetal death.
Objectives:1. To study the morphological and histological features of placenta in normal and hypertensive patients . 2.To Compare the two groups and study the correlation of their changes with the foetal outcome.
Material & Methods: 100 specimens of placentas of patients from normal as well as hypertensive group were collected from the labour room & operation theatre of Dept. of Obstetric & Gynaecology of Dr. Panjabrao Deshmukh Medical College and hospital, Amravati, Maharashtra .At first the gross features ( morphological features) of placentas were observed.. To study the histology , sections from each placenta of size 5mm were taken. This was fixed in in 10% formal saline and further histological processing of the tissue was carried out.
Observations & Results: The gross morphological features like weight, size, surface area, number of cotyledons were reduced and areas of infarction, retroplacental clot, calcification were increase in hypertensive placenta than normal placenta. (p<0.005) Similarly, the histological features like increased syncytial knots, intravillous and intervillous fibrin deposition, cytotrophoblastic proliferation, hyalinised villi, atherosis were observed in hypertensive placentas. These all changes were correlated with the foetal mortality and morbidity. And we observed that there was increase in foetal mortality and morbidity in hypertensive patients with the above histological changes in their placentas.

CORRELATION OF RISK FACTORS FOR PREECLAMPSIA WITH BLOOD PRESSURE AND PROTEINURIA

HidayatiRatna .; Hayati Farida; Fuadah Z. Dina; Sari K. Melani; Ludyanti L. Nita; Ishariani Linda

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 5, Pages 1017-1025

Background: Preeclampsia is related to the inability to adapt to the physiological changes of pregnancy that result in decreased maternal organ perfusion. This complex clinical syndrome in preeclampsia can affect all organ systems such as the hemodynamic system, kidney, retina, and blood chemistry, which is manifested by increased blood pressure and protein urine.
Purpose: This study aimed to determine the correlation of the factors causing preeclampsia with blood pressure and protein urine.
Methods: This correlational study using the 127 respondents, sampling purposive sampling techniques, the independent variable factor in preeclampsia (age, genetics, history of diabetes mellitus, history of hypertension), and the independent variable blood pressure and protein urine. The measuring instrument used is a sheet checklist and analyzed by Spearman rank.
Results: The results showed the risk of preeclampsia in the age factor of 40.9% occurred in the 28-35-year-old respondents; 100% of patients had no history/genetic preeclampsia, 100% of respondents did not have a history of diabetes mellitus, and 88.9% did not have a history of hypertension.Systole blood pressure increased moderately and high by 26.0% and 22.0%, while diastolic blood pressure increased moderately and high by 26.0% and 11.0%. Respondents had positive proteinuria of 52%. The results of the analysis are not found a significant correlation between the factors of age, genetics, history of diabetes, and history of hypertension with blood pressure and preeclampsia protein urine on respondents.
Conclusion: History of hypertension associated with blood pressure and proteinuria in preeclampsia. History of hypertension is related to the condition of the blood vessels that manifest hypertension and decreased renal function (protein urine). Therefore, it is recommended in women with a history of hypertension to control blood pressure and perform routine prenatal care during pregnancy to prevent further complications.

ORAL NIFEDIPINE VERSUS ORAL LABETALOL IN THE TREATMENT OF PREGNANCY INDUCED HYPERTENSION

R.P. Patange; Archna V. Rokadhe; Ghori R. Shinde; Sanjay N. Jadhav; Ashitosh Bahulekar

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 4136-4141

This study was undertaken to determine the effectiveness of two anti-hypertensive drugs: oral Nifedipine and oral Labetalol in cases of extreme preeclampsia in terms of their side effect profile, BP regulation, time taken to lower BP, and number of doses required. The objective of the study was to calculate the time required to reduce the blood pressure to the target level of 90 / 100 mmHg diastolic and less than 160mmHg systolic.In the labetalol group the mean SBP before treatment was 158mm of Hg which was reduced to 140 mm of Hg. The decline rate in the labetalol group was 11.77%. This study proved that labetalol reduces the BP more effectively than nifedipine and also has minimal side effects with less frequent dosing schedule as compared to nifedipine thus indicating that labetalol is better than nifedipine in lowering the BP in cases of preeclampsia.