Online ISSN: 2515-8260

Keywords : Infertility


An Epidemiological Study of clinic-demographic Profile of Patients with Infertility in Tertiary Hospital of North India.

Yati Tiwary, ShailendraPratap Singh, Tripti Gupta, Nitu Chaudhary, Disha Bansal, Ananya Katyal

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 2756-2760

Background:Infertility is not merely a health problem, it is also a social injustice and inequality. Infertility have a serious impact on both the psychological wellbeing and the social status of the women in the developing world. Objectives: to find out clinic-demographic characteristics of patients with infertility attending Obstetrics and Gynaecology OPD of RMCH Bareilly.
Materials and Methods: This was a one-year hospital based cross-sectional comparative study carried out in Department of Obstetrics and Gynaecology, Rohilkhand Medical College and Hospital, Bareilly, a tertiary care and teaching hospital in western Uttar Pradesh from 1st November 2019 to 31st October 2020 in women with age group 18-45 years presented with indications of primary and secondary infertility and the estimated sample size was 50.
Results: Highest percentage of cases (48%) have been reported for 21-30 age group, followed by 31-40 (38%), above 40 (12%) and below 20 age group (2%). The mean + SD value has been calculated as 31.96 + 7.77. Incidence among patients in high school is highest (34%), followed by primary school (32%), illiterate (22%), post high school (8%) and patients with graduate level education have reported lowest cases (4%).  Homemaker profession has the highest percentage of cases (72%), followed by daily wage worker (14%), other professions (8%) and working women (6%). Class III SES represents the highest percentage (48%), followed by Class IV (40%), Class V (6%), Class II (4%) and Class I represents the least percentage (2%). Most common symptom is menstrual dysfunction (40%), followed by abnormal vaginal discharge (28%), pelvic pain (16%), Fever/Malaise/loss of weight (8%) and very few have been asymptomatic (4%).
Conclusion: There is urgent need of regular health checkups and appropriate preventive, promotive and therapeutic interventions.

An Epidemiological Study of clinic-demographic Profile of Patients with Infertility in Tertiary Hospital of North India

Yati Tiwary, ShailendraPratap Singh, Tripti Gupta, Nitu Chaudhary, Disha Bansal, Ananya Katyal

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 2719-2723

Background:Infertility is not merely a health problem, it is also a social injustice and inequality. Infertility have a serious impact on both the psychological wellbeing and the social status of the women in the developing world. Objectives: to find out clinic-demographic characteristics of patients with infertility attending Obstetrics and Gynaecology OPD of RMCH Bareilly.
Materials and Methods: This was a one-year hospital based cross-sectional comparative study carried out in Department of Obstetrics and Gynaecology, Rohilkhand Medical College and Hospital, Bareilly, a tertiary care and teaching hospital in western Uttar Pradesh from 1st November 2019 to 31st October 2020 in women with age group 18-45 years presented with indications of primary and secondary infertility and the estimated sample size was 50.
Results: Highest percentage of cases (48%) have been reported for 21-30 age group, followed by 31-40 (38%), above 40 (12%) and below 20 age group (2%). The mean + SD value has been calculated as 31.96 + 7.77. Incidence among patients in high school is highest (34%), followed by primary school (32%), illiterate (22%), post high school (8%) and patients with graduate level education have reported lowest cases (4%).  Homemaker profession has the highest percentage of cases (72%), followed by daily wage worker (14%), other professions (8%) and working women (6%). Class III SES represents the highest percentage (48%), followed by Class IV (40%), Class V (6%), Class II (4%) and Class I represents the least percentage (2%). Most common symptom is menstrual dysfunction (40%), followed by abnormal vaginal discharge (28%), pelvic pain (16%), Fever/Malaise/loss of weight (8%) and very few have been asymptomatic (4%).
Conclusion: There is urgent need of regular health checkups and appropriate preventive, promotive and therapeutic interventions.

Infertile Women Seeking Conception Through Assisted Reproductive Technology Have Different Lipid Profiles and Atherogenicity Indices

Subasis Mishra, Mousumi Acharya, Subhra Samantroy, Anamika Mishra .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 3204-3210

Infertility in women is common over the world, and lipid abnormalities are thought to play a role. The goal of this study was to determine the plasma lipid profile and atherogenicity indices among infertile women who visited assisted reproductive technology clinics. In 140 infertile women and 50 healthy age-matched women of proven fertility, the serum lipid profile (total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and computed indicators of atherogenicity) was assessed.Using reagents provided by Randox Laboratories, Crumlin, Antrim, UK, the lipid profile was determined using the spectrophotometric method. The unpaired Students' test was used to compare the mean values of measured parameters between cases and controls. Age (p<0.001), total cholesterol, triglycerides, low-density lipoprotein, AIP, certain cardiac risk ratios, and atherogenic coefficients were considerably greater (p<0.001) in infertile women than in control participants, but high-density cholesterol was significantly lower (p<0.001). The difference in mean BMI between the patients and controls was not statistically significant. Except for the high density/low-density ratio, all atherogenicity indices were considerably greater in infertile women seeking assisted reproductive technology for conception than in control participants. This group of people has greater atherogenicity indices, which may predispose them to cardiovascular disease. As a result, it is recommended that lipid profiles and atherogenicity indices be evaluated on a regular basis.

A prospective assessment of the suitability of Letrozole as ovulating induction agent in patients with PCOS induced infertility

Dr. R Swapna, Dr. Akila Sree Gowri

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 1404-1409

Aim: to evaluate Letrozole as suitable ovulating induction agent in patients with PCOS induced infertility. Material & Method: The main source of data for this study are the women with primary and secondary infertility with anovulation attending the Department of Obstetrics & Gynecology, RVM Institute of Medical Sciences and Research Centre, Siddipet, Telangana, India. This is a prospective study with a total of 200 women satisfied the inclusion and exclusion criteria of the study. The present study consists of cases of infertility due to anovulation which were thoroughly evaluated before the diagnosis of anovulation was confirmed. Results: In this study mean age of the patients were 28.0 years and mean age of husbands were 32.4 year. 105 patients underwent diagnostic hysterolaparoscopy with chromopertubation + ovarian drilling. Conclusion: Letrozole can be considered as suitable ovulating induction agent in patients with PCOS induced infertility. It is a better drug in terms of mono follicular ovulation and better endometrial thickness than other ovulation induction agents. It has high ovulation rate with significant conception rate, with only drawbacks being miscarriages.

Relationship between Female Infertility and PelvicInflammatory Disease

Azahir Kamil Elsharif; Mohamed El-Sayed Mohamed; Sabry Nossair Wael; Taha Abdel- Fattah Mustafa

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 1007-1014

Infertility is a worldwide health problem among couples with approximately 15% current global infertility rate, translating to one in 6 couples suffering from this condition. The aim of the present study was to find the relation between infertility and pelvic inflammatory disease. Patients and methods: A cross-sectional case series study included 191 infertile women selected from the Outpatient Clinics of the Obstetrics and Gynecology Department, Faculty of Medicine, Zagazig University Hospitals. All women underwent general examination, local speculum examination, and abdominopelvic ultrasound. Also, we collected the data about past reports of all investigations, U/S, laparoscopic and HSG reports done during their journey on infertility assessment. Results: There was statistically significant difference between positive and negative PID patient's parity and social class. But regarding other variables, there was no statistically significant difference. There was statistically significant difference between positive and negative PID patients regarding methods of contraception, repeated history of PID and hospitalization due to PID. But regarding other variables, there was no statistically significant difference. There was statistically significant difference between positive and negative PID patients regarding WBCs and bacteruria. But regarding other variables, there was no statistically significant difference. There was statistically significant difference between positive and negative PID patients regarding using IUD as contraception. But regarding others, there was no statistically significant difference. Conclusion: Observed treatment of PID should be initiated in sexually active young women and others at risk for STIs if the following minimum criteria are present and no other cause(s) for the illness can be identified: lower abdominal tenderness or adnexal tenderness or cervical motion tenderness.

EVALUATION OF ROLE OF TRANSABDOMINAL ULTRASOUND IN UTERINE AND ADNEXAL FACTORS IN INFERTILITY

Dr Poonam Ohri, Dr Niveditha Basappa, Dr Kulwinder Kaur, Dr Manasi Kohli, Parushi Kohli, Dr Prabnoor Kaur

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 282-291

Background: The desire to procreate is universal phenomenon. Childlessness is considered
as a curse in many societies and is one of the causes of marital breakups. WHO has defined
infertility as ‘Failure to conceive over 12 months of uninterrupted sexual practice. USG has
become a well-established technique for imaging ovarian and uterine pathologies. Methods:
This is a hospital based cross sectional, observation study,included total of 51 cases. The
patients with chief complaints of infertility presenting to gynaecology OPDs were referred to
the department of Radiodiagnosis,Guru Nanak Dev Hospital, Amritsar and all patients were
subjected to transabdominal ultrasonography using 3.5 MHz sector transducer. Results: Out
of 51 cases studied, 35 were of primary infertility and 16 were of secondary infertility.
Duration of infertility varied from 1.75- 17 years in patients with primary infertility and 2-10
years in patients with secondary infertility,maximum cases between 2-4 years.. Nonspecific
enlargement of uterus on one case, 3 with fibroid, 3 with endometrial calcification, one with
infantile uterus and one bicornuate uterus. Ovaries were normal in 37 cases, abnormal in 9
cases, not visualized in 3 cases on left and 1 on right side. Left ovary enlarged in one case.
Ovarian cyst in 3 cases, T.O masses in 5 cases and PCOD in one case. Fluid in POD in 4
cases.Conclusion: It is concluded that ultrasound is very helpful in assessment of uterus and
adnexal pathologies. USG is non-invasive, cheap, acceptable, easily available modality. It can
diagnose structural abnormality and helps in making diagnosis of etiologic factor in patients
of infertility and also in management and follow up of patients of infertility.

Role of MRI in detecting female infertility

Dr. A Antony Jean,Dr. K. Karthikeyan,Dr.Ajit Kumar Reddy, Dr.AnnithaElavarasi J

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 3197-3201

To assess role of MRI in detecting female infertility.
Materials & Methods:Eighty- six women age ranged 20- 40 years were included in the
study. All underwent MRI using 1.5 Tesla unit equipped with a 32 phased-array surface
coil. Causes of female infertility was recorded.
Results: Age group 20-30 years comprised of 50 and 31-40 years had 36 patients. Various
causes of female infertility was PCOS in 12, tubal disease in 18, pelvic inflammatory
disease in 10, endometriosis in 8, leiomyoma in 6, adenomyosis in 12 and endometrial
polyps in 20 cases. A significant difference was observed (P< 0.05).
Conclusion: MRI is an excellent non-invasive, radiation-free modality for the evaluation
of female infertility; its superior soft-tissue contrast resolution and multiplanar evaluation
generate exquisite anatomical details.

Infertility predictors for prolactin-secreting pituitary adenomas

Kh.K Nasirova; Z.Yu. Khalimova; Yu. M. Urmanova; G.D. Narimova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2488-2503

Abstract: Purpose of research - To improve reproductive outcomes of women with
prolactinomas by evaluating fertility predictors. Material and methods. We examined 250
women aged 17-35 years (average age 30.5 years) with endocrine infertility (EI) and
hyperprolactinemia. Of these, 71 (28.4%) patients with prolactinoma and endocrine
infertility were selected for an in-depth study. All patients underwent a complete clinical -
hormonal and visualization examination and were divided into patients with EI with
pituitary microprolactinomas (64.7%) and patients with EI with macroprolactinomas
(35.2%). Clinical, imaging, and hormonal studies have been performed. The basal levels of
the pituitary gonadotropic hormones — LH, FSH, as well as PRL, TH, peripheral gland
hormones cortisol (C), estradiol (E) and total testosterone (T), dehydroepiandrosterone
sulfate (DHEA-S), progesterone, inhibins A and B were determined , activin, antimuller
hormone. The research materials were subjected to statistical processing using the methods
of parametric and non-parametric analysis. Results. According to the objectives, the
functional state of the HPO system and the clinical characteristics of infertility in
prolactinomas were studied, an analysis of complaints and anamnestic data of patients
with EI with prolactinomas was made, depending on the size of the formation in a
comparative aspect. The state of ovarian reserve was assessed, with the determination of
FSH, activin, AMH, inhibin A and B in the blood serum. The inhibin A level in both Me
groups was 1.30 ng/ml, which significantly differed from the control group (p₂ ˂0.0001,
p₃ ˂0.0001). The level of inhibin B underwent significant changes in both groups. A
decrease in inhibin B and an increase in FSH can prove a decrease in ovulatory ovarian
reserve. The studied women with EI in both groups showed a decrease in AMH, in the
group with microadenomas ranged from 0.12 to 2.1 and averaged 0.75 ± 0.27 ng/ml, and in
the group with macroadenomas ranged from 0.09-2.2 and averaged 0.97 ± 0.49 ng/ml,
which significantly differed from the control group (p₁ ˂0.05, p₂ ˂0.001 p₃ ˂0.001). The
conducted Spearman correlation and regression analysis showed that between prolactin
and AMH (r = -0.4; p˂0.01), between prolactin and progesterone (21dMC) (r = -0.576;
p˂0.0001) as well as between prolactin and inhibin B (r = -0.67) there is a strong “-“
negative relationship and all indicators were statistically significant. Conclusions:
Endocrine disorders in women with prolactinomas are significantly increased in patients
with macroadenoma compared with microadenoma. Correlation-regression analysis found
a negative relationship between PRL and AMH (r = -0.4, P <0.0001), PRL and
progesterone (r = -0.57, P <0.0001). With an increase in PRL by 1 unit, there is a decrease
in AMH by 0.008 units (P <0.001), a decrease in inhibin B by 0.11 (P <0.001),
progesterone by 0.04 units (P <0.0001) and the degree of hyperprolactinemia and this all
can predict EI development.

Features of perinatal outcomes in women after supporting reproductive technologies

Shakhnoza F. Bakhodirova; Gulchekhra A. Ikhtiyarova; Aslonova M.J .; Salim S. Davlatov

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 6350-6356

Pregnancy conceived with assisted reproductive technologies (ART) has a higher risk of maternal and perinatal complications, and the overall risk of adverse outcomes requiring extended obstetric care has not been thoroughly studied. The review is devoted to the actual problem of the health status of children born after IVF. A systematic review of the health indicators of children conceived with IVF after the neonatal period was carried out versus natural, conceived.