Online ISSN: 2515-8260

Keywords : expression


RESULTS OF AN IMMUNOGISTOCHEMICAL STUDY IN PATIENTS WITH POLIPOID RHINOSINUSITIS

Djuraev J.A .; Khasanov U.S .; Vohidov U .N; Botirov A.J. .; Shaumarov A.Z .

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2526-2541

Abstract: The marker of mesenchymal cells - vimentin with high and moderate expression
is present in both epithelial and stromal cells with "eosinophilic" forms of polyps and only
in the stroma in patients with "neutrophilic" polyps. The presence of high vimentin
expression indicates a high activity of mesenchymal cells. In the prognostic plan, these
changes indicate future relapses. Detection of the CD68 marker, its low and moderate
expression can mean low participation of macrophages in the formation of nasal polyps of
both forms. The presence of single stained cells in mesenchymal clusters indicates a low
phagocytic activity. The high and moderate expression of CD45 in mesenchymal clusters
located in “eosinophilic” polyps confirms our assumption that these mesenchymal clusters
are a “growth zone” of formations. High and moderate expression of CD138 in mature
epithelial cells in all tissue samples of both forms of polyps and the lack of expression of
this marker in clusters of mesenchymal formations, as well as average expression in cells
located in the stroma, may indicate the origin of the latter from active mesenchymal cells.
With the "eosinophilic form" of polyps, moderate and high expression of CD34 is detected.
These results confirm our assumption about the formation of a new vascular system in
mesenchymal clusters. Near the epithelium and in the stroma, a well-developed vascular
system is also observed. An increase in the number of vessels is a sign of recurrence, and
an increase in the number of newly formed vessels is prognostically unfavorable and
indicates the occurrence of relapse.