Online ISSN: 2515-8260

Keywords : myopia

Comparison of intraocular pressure variance in moderate and high myopia

Bhagyashree Sharma

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2611-2621

Abstract: Purpose: Intraocular pressure changes have been, and still is, a topic of discussion.
Increasing myopia has been constantly associated with increasing intraocular pressure.
Myopia has long been identified as a risk factor for open angle glaucoma because of the
changes in optic disc and pressure. Thus, repeated evaluation of all the factors that are related
to changes in IOP levels is important. This can help to figure out the risk factors for open
angle glaucoma in the form of variables that can be proved to be associated with IOP level
In this study, we will evaluate the intraocular pressure levels between moderate and high
myopia, also taking age and gender in to account
Methods: This is an Observational, hospital-based study conducted on 35 patients presented in
the HAH centenary hospital in the period of 2 months at Delhi. Data confidentiality was
maintained. The detailed demographic details along with ocular findings, systemic health
findings, were collected for analysis. The test used for statistical analysis were Un-paired, 2-
tailed, T-test, Two way ANOVA test. The software MS EXCEL was used.
Results: The hospital-based study conducted at HAH centenary hospital evaluated 35 myopic
patients (70 eyes) in the period of 2 months. Out of 35 patients, 20(57%) were moderate
myopic (-3.00D to <-6.00D) and 15(42%) were highly myopic (-6.00D and more). Range of the
age being 11- 55years. 20(57%) females and 15(42%) males were present in the sample. Only
one patient had IOP level more than 21mmhg and was further examined for glaucoma tests
which came out negative. All the evaluated patients had a C/D ratio less than 0.5
Conclusion: No significant association was found between IOP and myopia along with other
factors such as age and gender. Small sample size and avoiding various others factors such as
ocular biomechanics, corneal thickness, curvature etc. can be the reason for it. Overcoming these
limitations can help confirming a conclusion and give results that would be different and
convincing. The study needs further research time and evaluation.

The Usage of mitomycin-C With Photorefractive Keratectomy In Myopic Patients And Its Effect On Density Of Corneal Endothelium

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 4254-4260

Purpose: To evaluate the application of mitomycin-C on the density ofcorneal endothelialiumafter photorefractive keratectomy (PRK) in myopia patients.
Methods: We use case control study to evaluate 92 eyes of 46 patients (23 cases and 23 controls) with mean age of 27.6 years for cases group and 27.4 for control group (range: 20- 40). All patients were myopic ranged from -3.00 to -6D underwent photorefractive keratectomy (PRK). The first group (cases) wastreated with single usage of mitomycin-c for 30 seconds and second group (control) group was treated without mitomycin-c.The assessment was done by specular microscope before the procedure and after 3 months postoperatively for each eye to evaluate the density in corneal endothelialium (ECD) in both each group.
Results: Forty-six eyes of 23 cases and forty-six eyes of 23control patients with myopia were treated with photorefractive keratectomy. After three months of surgery the mean ECD was decreased significantly.
Conclusion: The use of mitomycin-c for 30 seconds in myopic patientstreated by PRK would affectcorneal endothelial cell density after three months postoperatively.