Online ISSN: 2515-8260

Keywords : Chronic obstructive pulmonary disease


Health care seeking behaviour of chronic obstructive pulmonary Disease patients: Results from a community based cross-sectional study

Dr. Malik Shanawaz Ahmed, Dr. Ishan Kumar Parashar, Dr. Mohammed Parvez, Dr. Rajendra Kumar Shukla

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 404-409

Introduction: Chronic obstructive pulmonary disease causes significant mortality and morbidity
worldwide and in India. It is characterized by airflow limitation that is not fully reversible. Better health
care seeking behaviour may halt the progression of disease and improve their quality of life. This study
assesses health care seeking behaviour of chronic obstructive pulmonary disease and factors affecting it.
Material and methods: All 205 patients diagnosed with chronic obstructive pulmonary disease using
spirometry in a large community based study were enquired about their health care seeking behaviour.
Chronic lung disease severity index was used to assess the severity of symptoms. Sociodemographic data
was also recorded. Factors affecting their healthcare were enquired of using a semi-structured
questionnaire.
Results: Large number of patients were under diagnosed and untreated. Public sector was preferred with
being asymptomatic or few symptoms and high cost being major barriers for not taking treatment. Severe
symptoms, later stages of disease, lower standard of living & those living in rural areas had a significantly
lower treatment seeking behaviour.
Conclusion: Chronic obstructive pulmonary disease patients were having poor health care seeking
behaviour.

Evaluation of Peripheral Neuropathy in Patient with Stable Chronic Obstructive Pulmonary Disease: A Hospital-Based Study from North India

Vandini Singh

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 10532-10540

Background:Chronic obstructive pulmonary disease (COPD) is characterized by
obstruction in airflow; however, COPD is a systemic illness. Neurophysiological
alterations, such as nerve conduction (monosynaptic reflex test) and strength, have been
correlated with smoking, the severity of the disease, hypoxemia, age, hypercapnia and
peak expiratory flow. In this study, we aimed to evaluate the peripheral nervous system
(PNS) with electromyography (EMG) method in patients with COPD and to examine
their relationship with each other.
Materials and Methods: The study was conducted in the Department of Physiology in
collaboration with the Department of Pulmonary Medicine in New Delhi Medical
College and Hospital in Delhi. Our study was conducted among two groups: patient
group (included COPD cases) and control group (included healthy volunteers).
Spirometry was done using MEDGRAPHICS body plethysmograph. Nerve conduction
studies were performed on median, ulnar, peroneal, tibial and sural nerves using
NEURO– MEP–NET EMG/NCV/EP (NEUROSOFT TM) Equipment. The data for
each nerve parameter in the two groups were analyzed Students’ T test.
Results: 39 patients with stable COPD in addition to 39 healthy volunteers as a control
were included in this study. The mean age for patient group was 62.78±7.11 years and
for control group it was 60.13±9.83 years. Males in the patient group were 89.7% and in
control group they were 87.2%. The pulmonary function tests revealed a significant
decrease of FEV1, and FEV1/FVC in the COPD group when compared to the control
group. The patient of COPD was grouped in accordance with these GOLD criteria and
28.2% of patients were having Mild COPD, while 35.9% of patients each were having
moderate and severe COPD. Results of the nerve conduction study showed that there
was a statistically significant decrease in amplitude (mv) and velocity (m/s) and increase
in latency (ms) of peripheral nerve motor and sensory in the COPD group when
compared to the control group.
Conclusion: This study shows that advancement in severity of disease predisposes to
neuropathy. Hence, sensory nerve conduction study can be advised routinely and at
regular intervals to the patients suffering from increasing severity of COPD for early
detection of neuropathy.

General anaesthesia for patients with chronic obstructive pulmonary disease undergoing spinal surgery and postoperative respiratory failure: An observational study

Dr. Abdul Wahab Mirza, Dr. Deepinder Kaur, Yogesh Kumar Chhetty

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 2029-2032

Background: Patients with the chronic obstructive pulmonary disorder (COPD) are at risk of developing postoperative respiratory failure. That is the reason they may require artificial respiration for longer periods than others. However, being on mechanical ventilation for a long time leads to lung damage and infections.
Objective: The present study was undertaken to observe the relation between the severity of COPD in patients of spinal surgery and the prevalence of respiratory failure.
Materials and Methods: 40 patients with COPD who had undergone spinal surgery were part of the study. The data was collected from the medical records department including the demographics, spirometry results, blood gas analysis, comorbidities, postoperative and other variables. The important outcome is a respiratory failure within one week after the surgery.
Results: Data was presented in table 1 and table 2. Table 1 presents the demographic and clinical parameters of the participants. Table 2 presents the risk factors for respiratory failure of the participants. A longer duration of anesthesia was required for the mild COPD patients. Comorbidities were present in all levels of COPD patients. Table 2 presents the risk factors for respiratory failure of the participants. Length of stay was longer in patients with severe COPD. Extubating time, and endotracheal intubation after surgery were more in the severe COPD patients. Pulmonary infection is present in all groups of patients.
Conclusion: There is no significant relationship between the severities of COPD with postoperative respiratory failure. However, there is a strong need to conduct a prospective study with more defined parameters to understand better these relations. So that better and more effective treatment strategies can be developed.

CLINICAL AND X-RAY PECULIARITIES OF THE COURSE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN COMBINATION WITH DIABETES MELLITUS

Jamshed Turdumatov; Gulshod Mardieva

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 3009-3028

At present, the important role of comorbid diseases, including diabetes
mellitus, in the course of COPD has been determined. Concomitant diabetes
mellitus accelerates the progression of ventilation disorders and worsens the
prognosis, increasing the risk of mortality from COPD. Diabetes mellitus is
associated with COPD from 2 to 16%. Potential mechanisms underlying the
high incidence of the combined course of COPD and type 2 diabetes mellitus
include: chronic systemic inflammation, oxidative stress, and chronic
hyperglycemia.
Purpose. determination of clinical, functional and radiological features
of COPD in diabetes mellitus.
Materials and methods. We examined 75 patients and studied the
features of the course of COPD in combination with diabetes mellitus in
comparison with the results of examining patients with COPD and patients
with diabetes mellitus by X-ray and MSCT.
Results. Patients with COPD in combination with diabetes mellitus are
characterized by more pronounced respiratory failure and chronic cor
pulmonale, frequent exacerbations and more pronounced hypoxemia in
comparison with patients with COPD. Standard radiography did not reveal
pronounced differences between the examined groups of patients with COPD.
COPD is formed as a result of damage to the small bronchi, which determines
the characteristic clinical and radiological symptom complex. In the structure
of COPD, there is a pulmonary component and systemic manifestations that
aggravate the disease. The manifestations of diabetes mellitus are based on
micro- and macroangiopathies that affect pulmonary microcirculation.
Conclusions. Diagnostically significant for COPD during MSCT is a
symptom of expiratory "air trap", combined with expansion and deformation of
the bronchi, up to bronchioectasis. At MSCT in patients with COPD and
diabetes mellitus, pathognomic changes characterizing microangiopathy:
dilated parenchymal vessels, focal-like shadows of vascular origin with a
diameter of 2-5 mm, a clear-cut shape of the vessels, which are considered as a
consequence of specific microangiopathy and fibrotic changes in COPD.