Online ISSN: 2515-8260

Keywords : Metal Complex


IN THE CONDITIONS OF COVID-19,SYNTHESIS AND ANALYSIS OF COORDINATION COMPOUNDS OF COPPER (II) CHLORIDE WITH MONOETHANOLAMINE AND P-NITROBENZOIC ACID

Khudoyberganov Oybek Ikromovich; Ibragimov Bakhtiyar Tulyaganovich; Ashurov Jamshid Mengnorovich; Ibragimov Aziz Bakhtiyarovich; Khasanov Shodlik Bekpulatovic; Azizjanov Khushnud Maksudovich

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 3147-3154

The article highlights the study of the synthesis of a complex
combination of p-nitrobenzoic acid with Cu2+from aromatic carbonic acid
derivatives. Influencing factors on the synthesis of complex compounds in the
room were studied. Specifically, the time dependence of the reaction, the effect
of temperature, the concentration dependence wasobserved in practice. The
synthesized complex was evaluated by means of IR-Fourier spectrometry,
elemental analysis, mass spectrometry, TG-DSK and X-ray structural analysis to
determine its chemical structure, as well as to justify that the new complex is
thermally and chemically steady.

Synthesis, Characterization And Biological Evaluation Of Schiff Base Of 5-Chloro Salicylaldehyde Hydrazine N-Methyl Carbo- Thioamide And Its Metal Complexes: Cytotoxicity, Dna Interaction & Incision, Antibacterial And Antifungal Studies

Pilli Jyothi; C. Gyana Kumari

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 4339-4355

A Schiff base ligand of N-methyl Thiosemicarbazide and its complexes with Co metal ion
of binary [Co(L)2] (Complex-A), and ternary, formulae [Co(L)(L1)(H2O)] (Complex-B),
[Co(L)(L2)(H2O)] (Complex-C) where L is Schiff base ligand, L1 is Bi-pyridine and L2 is
oxalic acid have been synthesized and the compounds had been characterized based on the
several spectroscopic results. The interaction of these compounds with DNA was
investigated by electronic absorption spectroscopy and fluorescence spectroscopy. Our
experiments indicated that these complexes could strongly bind to CT- DNA via
intercalation mode with Kb values of 1.2 x 104 M-1 to 5.7 x 104 M-1 and the nucleotide
incision against super coiled pBR322 DNA had been investigated by both photolytic and
oxidative techniques to reveal the efficient manner of cleavage by the metal complexes.
Furthermore, these complexes exhibited significant in vitro Cytotoxicity against HeLa &
MCF7 cell lines showing IC50 values around 46.03 to 62.05 μM. Finally, an antimicrobial
assay of these complexes over one gram-positive bacterium of Bacillus Subtilis and one
gram-negative bacterium of Escherichia Coli and also two fungal species had given a good
result.