Online ISSN: 2515-8260

Keywords : Stem cell therapy

Advanced treatment regimes and application of regenerative medicine for human male infertility treatment

A.S Vickram; G.V. Sree Charan; P. Venkatasaikumar; M. Kusuma; P.N. Ramya Bhargavi; G. Gulothungan; S. Thanigaivel; P. Jeyanthi; R. Nanmaran

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 5746-5766

Male reproductive organ and other assessory sex glands plays an massive role in sperm production process, sperm maturation process, maintaining the entry of sperm cells in the female reproductive tract and until child birth. Many events could happen properly from semen ejaculation until it reaches the oozyte for proper fertilization. Any problem during the process of semen reaching female reproductive tract could men responsible. Overall 20 to 35 % of men contribute to the infertility. Clinical evidence suggests that tissue engineering and regenerative medicine could help men achieve the fertility status. Congenital abnormalities, iatrogenic injuries, trauma and other chronic conditions could be treated by regenerative medicine. Recently stem cell therapy has been emerging in the file of male infertility treatment regimes. In case of trauma, penile reconstruction, testes reconstruction available as most advanced treatment regime. Here we summarized the important findings and functions of testes, penile and scrotum reconstruction techniques, organ based regeneration for various male infertile disorders. Non-obstructive azoospermia conditions will be very tough to diagnose and this review comprises the important treatment regimes available for non-obstructive azoospermia. Antioxidants therapy, trace elements therapy, oral administration of carnitines and its potential applications were carefully elucidated for idiopathic conditions. We also summarized the role of prebiotics and probiotics as treatment regime for male infertility. All advanced treatments methods available were in general summarized in this review.


Mohamed Thameemul Ansari.K. A; Raghu Nandakumar; A.K. Anjali

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1834-1838

Stem cells are special human cells that can develop into any cell type of the organism if it's induced and have the ability to renew themselves under suitable conditions. Applications of stem cells exist in manyfields. A Review study is conducted to analyze and investigate dental Pulp stem cells and its application. Human pluripotent stem cells (either human embryonic stem cells or induced pluripotent stem cells) can differentiate into every cell type of the human body with infinite self-rentention capacity. Hence, pluripotent stem cells are an ideal source to generate specialized cell types for cell replacement therapy, e.g. beta cells for diabetics Nevertheless, due to a large number of differentiation steps, current protocols for in vitro cell differentiation are rather complex.. To regulate the cell growth and differentiation, almost 20 signaling proteins and small molecules last for more than four weeks. Not all cells differentiate into the targeted cells but take incorrect differentiation paths during this multistep process.. This can lead to a highly heterogeneous cell population with beta cells that are not fully functional. This paper reviews the recent studies and researches about dental pulp stem cells and their applications in the field of dentistry.