Online ISSN: 2515-8260

Keywords : inflammation


Design And Development Of Herbal Tablet Containing Ethanolic Extract Of Diplocyclos Palmatus (L.) Jeffry. For The Treatment Of Inflammation

Paras Gupta; Alok Mukerjee; Anil K. Singh; Bhupesh K. Verma; Sumeet Dwivedi

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 443-452

Diplocyclos palmatus (L.) Jeffry. commony known as Shivlingi belongs to family Cucurbitaceae had been widely used for its reported biological activities in indigenous system of medicine. The present investigation was designed to develop herbal tablet containing ethanolic extract of leaves of Diplocyclos palmatus (L.) Jeffry. for the treatment of inflammation. The developed herbal tablet was evaluated as per IP. Hence, present investigation established pharmacological evidences to support the folklore claim that Diplocyclos palmatus (l.) Jeffry. is used as anti-inflammatory agent.

The Dynamics of C-reactive Protein Associated with Nutritional Status Changes in Kidney Failure Patients at Initiation and After 3 Months of Dialysis

Trina Primalia Irawanti; Haerani Rasyid; Syakib Bakri; Hasyim Kasim; Andi Makbul Aman; Fabiola Maureen Shinta Adam; Nur Ahmad Tabri; Arifin Seweng

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 152-159

Among kidney failure patients, especially those on dialysis, malnutrition is associated with poor outcomes. Malnutrition is a multifactorial process, including inflammation, which can be measured by C-reactive protein (CRP). The objective is to evaluate the dynamics of CRP associated with nutritional status changes in kidney failure patients at initiation and after 3 months of dialysis. A prospective cohort study using a consecutive sampling method consisting of 40 kidney failure patients who received initial dialysis at Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia from January-March 2020. Nutritional status was evaluated with Subjective Global Assessment (SGA), and CRP was measured at the initial dialysis and after 3 months. All subjects received nutritional education at the beginning. Nutritional status was defined as well-nourished (WN, SGA A) and malnourished (MN, SGA B and C), then classified into 4 groups denoting nutritional changes: Group 1 (WN to WN), Group 2 (MN to WN), Group 3 (WN to MN), and Group 4 (MN to MN). ANOVA, paired t-test, and chi-square test (significance p<0.05) were used for statistical analyses. Subject’s mean age was 50.5±14.8 years old; 52.5% were male. Diabetes and obstructive nephropathy were the most frequent underlying diseases, both had a prevalence of 35%. At initiation, the prevalence of malnutrition was 77.5%; after 3 months, it was 70%. The highest proportion of Group 4 were female (62.5%) and those with diabetes (45.9%). Among all subjects, mean CRP decreased (9.4±32.3 mg/dL) after 3 months. While mean CRP based on nutritional changes, Group 2 had the highest reduction (18.8±26.8 mg/dL), and Group 3, CRP increased (17.5±17.0 mg/dL). C-reactive protein is negatively associated with nutritional status changes in kidney failure patients after 3 months of dialysis. Malnutrition was higher in female subjects and those with diabetes.

Carbon Nanotubes In Treatment Of Arthritis: An Overview

Manvendra Singh; Pallavi Nayak; Vijay Mishra

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4366-4372

Arthritis is a type of joint dysfunction that includes one or more joint inflammation like rheumatoid or psoriatic arthritis, and associated autoimmune disorders. The biggest concern about arthritis is that the discomfort is always persistent and may be confined to the injured joint due to swelling that happens throughout the joint, trauma to the joint induced by illness, regular wear and tear, muscle strains triggered by vigorous action toward hard sore joints and exhaustion, which in effect contributes to inflexibility, immobility and muscle weakening. Carbon nanotubes with unusual physicochemical properties (cell membrane penetration, large surface area and drug payload, biocompatibility, simple surface alteration, photoluminescence properties and non-immunogenicity) are employed to conquer the challenges of inflammation.

A Review Study On Relationship Among Covid-19 And Inflammation

Mr.Ponnazhagan .; Dr.Amarendiran .

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 5440-5444

In reality, numerous research works have begun to report the metabolic function of COVID-19 shifts. Characteristically characterised are I decline in low-density (LDL-c) and high-density (HDL-c) cholesterol lipoproteins, (later proportionate with the gravity of the symptoms), and (ii) a mild rise in the populating T-assistance cell populations (CD3+T, CD4+T) and (iii) CD8+T lymphopenia. Further, in seriously ill patients the overall counts of White Blood Cells (WBC) is considerably higher, with a macrophage activation syndrome that was supported by the existence of the bronchoalveolar monocyte recruitment chemokines.

USES OF MEDICINAL PLANTS FOR ANTI- INFLAMMATORY ACTIVITY - A REVIEW

FarhatYaasmeenSadiqueBasha .; Rajeshkumar. S; SS Raj

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1839-1843

Inflammation is a natural immune process caused by physiological disturbance in the body. The characteristic signs of inflammation are redness, heat, swelling, pain and loss of function. This whole process is a protection mechanism produced by the body following any injury.
But sometimes this also ends up harming the body. For such times drugs are needed to suppress this condition, they are called anti inflammatory drugs. NSAIDs are the widely used drugs of choice. Examples are aspirin, diclofenac, mefenamic acid etc. But the prolonged use of these drugs is also known to produce side effects. Many plants are said to contain phytoconstituents that possess anti inflammatory activity. Since plants are natural, easily available and produce little to no side effects, they are believed to be a safer source of cures or drugs.
The aim of this review is to determine the state of knowledge on medicinal plants and their antiinflammatory activity. This review discusses how plants may be used in medicine for their anti inflammatory activity.