Online ISSN: 2515-8260

Keywords : Serotypes

A Prospective Study on Etiopathogenesis of Various Pneumococcal Serotypes in Invasive Respiratory Tract Infections in a Tertiary Care Centre in Western Uttar Pradesh

Sandhya Lata, Jayesh Shakeet, Abhilasha Smith

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 10514-10522

Background: Acute respiratory tract infections are a major cause of under-five
childhood morbidity and mortality across the world. Knowledge of pathogenicity and
invasiveness of serotypes can help in predicting the course of disease and will permit
necessary interventions to be taken in time. This will result in better opportunities of
care and significant decrease in morbidity and mortality associated with pneumococcus.
The aim of this study to identify the various pneumococcal serotypes affecting children
as pneumococcal invasive disease and to study the clinical presentation, invasiveness
and the morbidity and mortality caused by them.
Materials & Methods: It was a hospital based prospective analytical study done at K.D.
Medical College, Mathura. All patients within the age group of six months to eighteen
years were enrolled in the study. All patients admitted with community acquired
pneumonia were screened for evidence of sepsis with the help of routine investigations
and acute phase reactants (CRP and Procalcitonin). Clinical profile was studied, and an
attempt was made for identification of causative organism by means of Blood culture
and DNA PCR.
Results: Out of 716 cases admitted with LRTI, 316 were considered to be bacterial in
origin based on clinical presentation, X-Ray findings (classical
Consolidation/Empyema), Neutrophilic Leukocytosis, raised Acute Phase Reactants
(CRP/PCT) or Blood Culture positivity. Causative organism was identified on basis of
blood culture in 28.4% cases. Pneumococcal infection was documented by blood culture
in 0.69 % cases while evidence of invasive pneumococcal disease in form of
identification of serotype was obtained in 30% cases. 21 different pneumococcal
serotypes were identified. Serotype 1 was most common isolate. Other common isolates
were serotype 14, 6B, 7F, 9B, 19F, 9N, 18C, 19A, 20, 10F and 5. Serotypes 18C and 19A
were associated with maximum mortality. Serotype 14 was another most virulent


Raja kumar; Jothi Priya; V. Vishnu Priya; Lakshminarayanan Arivarasu

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 2307-2321

Dengue is especially affecting the tropic and subtropic regions of the planet . It's mainly caused by Dengue, a member of Family Flaviviridae. Four serotypes of Dengue are DENV1, DENV2, DENV3 and DENV4. 67,000 people are diagnosed by Dengue and it's been reported by NVBPCP. The aim of this study is to make awareness on risk factors and complications of Dengue virus among college students .The Survey on awareness about the danger factor and complications of Dengue virus among college students was conducted employing a google form link. We've distributed our survey among 100 college students. Then , we used a sampling method. Also, we've used statistical software as SPSS for our data. 59.05 % agreed that they're conscious of Dengue virus, 40.95% are still not aware . 58.10 % agreed that it had been transmitted by files, 27.62 % responded thanks to mosquitoes, 11.43 % responded thanks to Aedes mosquito, 2.86 % responded and still don’ t know. Awareness camps , social media , workshops , seminars could also be conducted to make awareness of risk factors and complications of Dengue virus among college students.