Online ISSN: 2515-8260

Keywords : antihyperlipidemic

The Antihyperlipidemic Property of the Crude Methanolic Extract of Antigonon Leptopus Hook & Arn. (Polygonaceae) Leaves in Triton X-Induced Hyperlipidemic Male Sprague-Dawley Rats

Ellize Zaira B. Balboa; Ian M. Hernandez; Alyanne Sigrid D. Ilagan; Dianne Mae C. Malabag; Ma. Lance Laurice G. Vale; Sheryl C. Aguila; Omar Villalobos

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 4208-4220

Hyperlipidemia is a major factor that can promote atherosclerosis and atherosclerosis-related conditions. Cardiovascular disease (CVD) is the epidemic of modern civilization in which hyperlipidemia contributes significantly to its pathogenesis. This study aimed to investigate the antihyperlipidemic property of Antigonon leptopus leaves using the methanolic crude extract (ALME) in Triton-X-100 induced hyperlipidemic male Sprague-Dawley rats during seven-day treatment period. The efficacy of ALME 100, 200, 400mg/kg was compared to the standard simvastatin (10 mg/kg, p.o.) in Triton X-100-induced hyperlipidemic rats. Effect of ALME on serum lipid profile like Total Cholesterol (TC), Triglycerides (TG), Low-Density Lipoprotein-Cholesterol (LDL-C), Very Low-Density Lipoprotein-Cholesterol (VLDL-C) and High-Density Lipoprotein-Cholesterol (HDL) were estimated. The results demonstrated that the ALME has an antihyperlipidemic potential. Different doses of ALME significantly reduced the TC, TG, LDL-C, and VLDL-C in Triton X-100-induced hyperlipidemic rats (p-value <0.05). The histopathological evaluation also revealed the positive effect of the plant extract, with ALME 100 mg/kg showing promising tissue-specific antihyperlipidemic effect.

Antihyperglycemic And AntihyperlipidemicAntihyperlipidemicproperties Of Naregamia Alata (Meliaceae) In Alloxan Induced Diabetic Rats

Raja Jency Esther R; Stanley Raja VK

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 3996-4003

The present study was carried out to investigate the antihyperlipidemic and antihyperglycemic properties of the ethanol extract of Naregamia alata in alloxan induced diabetic rats(150mg/Kg). The ethanol extract of Naregamia alataat a dose of 200mg/kg of body weight were administered at single dose per day to diabetes induced rats. The effect of ethanol extract of N. alata extract on body weight, blood glucose, plasma insulin, glucose, urea, creatinine, glycosylated haemoglobin, serum protein, albumin, globulin, serum enzymes [serum glutamate oxaloacetate transaminases (SGOT),serum glutamate pyruvate transaminases (SGPT) and alkaline phosphatase (ALP)], serum lipid profile [total cholesterol (TR), triglycerides (TG), high density lipoprotein – cholesterol (HDL-C), very low density lipoprotein – cholesterol (VLDL-C), low density lipoprotein – cholesterol (LDL-C), and phospholipid (PL)] were measured in the diabetic rats. Treatment with N. alata and standard drug caused significant (p<0.05) changes compared to the untreated animals with respect to various parameters like body weight, blood glucose level, SGOT, ALP, TC and LDL. From the above results, it is concluded that ethanol extract of N. alata possesses significant antihyperglycemic and antihyperlipidemic effects in alloxan induced diabetic rats.