Online ISSN: 2515-8260

Keywords : MCV

A Prospective Study on Haemotological Profile of Sickle Disease

Dr Haseeb Ul Haq , Dr Raghunath S.V Dr V.Sushma

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 2871-2875

Objectives and Aim: The aim of this study was to determine Haematological profile of Sickle cell disease (SCD) from Karimnagar Region, Telangana, India
Methods: This Prospective Cross-Sectional Study was conduct­ed in the Department of Paediatrics, Prathima institute of medical sciences, Karimnagar India, between June 2019-Feb 2020.37 children between the age of 6 years to 15 years
Results: A total of 37 children’s homozygous (SS) (mean age 11.6±3.4 years) for sickle cell anaemia was studied for their haematological parameters. Out of the total SS subjects, 26 were males and 11 were females
Conclusion: We conclude that moderate to severe anaemia with, low MCV and high HbF dominate the haematological profile

A Hospital Based Prospective Study to Estimate the Prevalence of Vitamin B12 Deficiency in Vegetarian Outpatients Between 18-60 Years of Age Presenting at a Tertiary Care Centre

Devendra Dadhich, Darshan Kumar Bhargava, Mukesh Verma, Rajesh Meena, Ummed Singh

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 10954-10962

Background: Vegetarianism has been well known and commonly found in India since
ancient times. Animal products provide the only dietary source of vitamin B12. Vegetarianism
is a well-known risk factor for vitamin B12 deficiency. The aim of this study to determine the
prevalence of vitamin B12 deficiency among vegetarian outpatients, between the age groups
of 18 and 60 years, visiting the internal medicine outpatient department of a tertiary level
teaching hospital.
Materials& Methods: A hospital based prospective study in department of medicine at
government S.K. Medical College, Sikar, Rajasthan, India during one year period. A
prevalence study for any factor is best done in the community – in a lot of situations that
would reduce the bias of a hospital study. This being a hospital study has its own limitations.
However as far as possible we wanted to choose a population in our hospital survey that
would most closely reflect the community or the general population at largeVegetarian
patients were defined as patients that had been consuming a diet devoid of any form of meat,
at least for three completed years prior to the date of recruitment. At the point of contact with
the subject in the outpatient department he or she also underwent certain biochemical and
haematological tests that included serum vitamin B12 and folate levels, and basic
Results: In our study population, 61.25% had levels below 200, 22.5% had levels
between200and300and16.25%hadlevelsabove300 pmol/L. The mean vitamin B12 levels in
the three groupsrespectively were 144.8, 269.2 and 233.4. There was no statistically
significant differencebetweenthe groupsbyANOVA. At various laboratory parameters among
the three varieties of dietconsumers – however the numbers were too small for any statistical
analysis betweenthem. Mean corpuscular values of less than or equal to 100fl were
European Journal of Molecular & Clinical Medicine
ISSN 2515-8260 Volume 9, Issue 3, Winter 2022
categorised asnormocytic category and anything higher than that was considered as
qualifying formacrocytosis. A folate level cut-off at 9.5 was also taken to look for prediction
ofvitaminB12 deficiency.
Conclusion: The vegetarian diet can be sustainable at all stages of life and in all
physiological conditions, including infancy, pregnancy, lactation, senescence and sports.
However, underestimating the correct supplementation of cobalamin (Cbl) can nullify these
benefits. It is also necessary that the diet be balanced and nutritionally adequate to reduce the
risks of other deficiencies which could indirectly affect the absorption of Cbl.

The Effect Of Giving Extracted Moringa Oleifera Leaves Plus Royal Jelly Supplement On Erythrocyte Index Of Anemia Pregnant Women In Takalar District

Dewi Hastuty; Veni Hadju; Andi Ariyandy

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 701-710

Background: This study aims to determine the effect of giving moringa oleifera leaves extract plus royal jelly supplement on increasing erythrocyte index in anaemia pregnant women.
The method of the research: The research method used is randomized controlled design. The research was conducted in Polongbangkeng Utara Sub district (Puskesmas Polongbangkeng Utara, Ko'mara and Towata) Takalar Regency with a Haematology Analyze examination at the Clinical Pathology Laboratory of the UNHAS Hospital. Subject of the study is 63 anemia pregnant women consisting of 21 subjects of Moringa Leaf Extract plus Royal Jelly (MLERJ) group with the intervention of 1 capsule in the morning with a dose of 500 mg MLE + 10 mg RJ, 21 subjects of Moringa Leaf Extract (MLE) with the intervention 1 capsule in the morning with a dose of 500mg MLE and the Placebo group 21 subjects with the intervention 1 placebo capsule in the morning with a dose of 500mg starch flour, where all of the subjects consumed Fe tablets at night with a dose of 1x60mg. Data were analyzed using the Chi-Square, Mann-Whitney, Wilcoxon, Paied T-Test, Kruskal-Wallis and Post-Hoc Mann Whitney tests.
Results: Based on the characteristics of research subjects based on age, education, occupation, income and parity, the three research groups were not different or evenly distributed. The results showed an increase in the erythrocyte index levels (MCV, MCH and MCHC) of the three study groups. Where in the MLERJ group the levels of MCV, MCH and MCHC experienced a significant increase, in the MLE group who experienced a significant increase in MCV and MCHC levels, while in the Placebo group who experienced a significant increase only in MCV levels.
Conclusion: Supplementation Moringa Leaf Extract Plus Royal Jelly is more effective at increasing the erythrocyte index levels (MCV, MCH and MCHC) in anemic pregnant women so that it can be used as an alternative treatment to treat anemia.