European Journal of Molecular & Clinical Medicine

Exercise has been implicated in modulating dopamine in a major amount as neurotransmission, increasing blood flow, etc. The role of exercise in tumor risk reduction, there is now convincing and vital evidence that exercise reduces melanoma and also other tumors. This has to be practiced in each and every place where tumor has grown. The goal of the study is to study the impact of exercise induced dopamine replica in modulating the apoptotic signaling pathway in human melanoma.
The melanoma cell line of human cell (A375) was brought from NCCS, Pune, India. Cell viability test and Gene expression analysis were carried out using MTT and PCR respectively. The results were analyzed using appropriate statistical tools using ANOVA and Duncan’s  test.

principal point appropriate facing    this paper was facing analyze impact appropriate facing    man-made consciousness on present day world, particularly  include field appropriate facing    money. This exploration centers around utilization appropriate facing    computerized reasoning, its difficulties, open doors  also   its effect on positions  also   works. This examination technique reasons that all through worth chain  include monetary administrations can finish things.

Uzbekistan differs in hot climatic conditions from the Russian lands, where sunflower seeds are mainly grown. In connection with this, we studied the component compositions, the effect of moisture on the bulk density and other equally important indicators of sunflower seeds and products of its processing. It has been established that sunflower seeds cultivated in the hot climatic conditions of Uzbekistan have distinctive features in physical-mechanical and physical-chemical properties than in the Russian regions. The linear dimensions, component compositions, the effect of moisture on the bulk density of sunflower seeds have been determined. It has been established that in the hot climatic conditions of Uzbekistan, the cultivation of sunflower seeds is more efficient than in the Russian regions.

The objective of this research is to (1) study the components of innovation and digital marketing that affect the small and medium enterprises (SME) performance (2) analyze the influence of innovation and digital marketing that affects the SME performance (3) study the SME performance development model. In this mixed research, there were nine key informants and 460 questionnaires were used. The statistics used were percentage, mean, standard deviation, frequency, Pearson correlation coefficient, percentage, mean, standard deviation, survey factor analysis, and analysis of structural equation model. Found that there are three components of innovation, three components of digital marketing, and SME performance has two components. The model shows that innovation has a direct influence on SME performance, innovation has a direct influence on digital marketing, digital marketing has a direct influence on SME performance, and innovation has an indirect influence on SME performance

The authors of the article investigated the innovative aspects of reforming higher education in a new stage of development of the Republic of Uzbekistan. The article emphasizes the role of the process of training competitive specialists in the successful implementation of democratic reforms and the development of civil society. The authors of the article made an attempt to reveal the mission of higher education in society, the tasks of universities in training qualified personnel for bachelors and masters and the importance of specialists for the socio-economic structures of the country in the process of deepening the market economy. In the context of the country's modernization, highly qualified personnel perform an important mission in the process of socio-economic policy, ensuring the improvement of the quality of products and the country's entry into international communities. University graduates carry out a social mission in implementing democratic reforms, ensuring human rights, and educating the younger generation in society

This article aims to elaborate the innovations on the Qurban procession during the Covid-19 pandemic by following health protocols. The approach employed is normative-empirical by looking at the texts of revelation, the views of scholars, fatwa products, government policies and relevant journals, online news and the realities that occur in society. The result of the study found that the innovation of of Qurban procession consists of 3 parts. First, the payment system is done by collaborating with online payment services. Second, the process of slaughtering specificied to certain locations that meet health protocols. third, distribution of qurban products is in collaboration with online transportation providers. These innovations are a response to the Government's policy through the relevant ministries to issue a circular to continue to carry out the slaughter of sacrificial animals in a safe location and able to break the chain of the spread of Covid-19. MUI and Muhammadiyah also issued fatwa products in which there was no significant difference. Government policies and existing fatwa products continue to comply with one of the religious teachings every year by implementing the slaughter of sacrificial animals with strict provisions in accordance with health protocols.

This article reveals the features of developing a marketing strategy for an enterprise. The development of a marketing strategy is a complex process that requires in-depth research of the state and development of the market, as well as an assessment of the position of the company that it occupies in the market. At the level of the enterprise as a whole, a general strategy is formed that reflects the general strategic line of development and a combination of its possible directions, taking into account the existing market conditions and the capabilities of the company. Strategy focuses on what the firm does and does not do, which is more important and less important in the current activities of the firm. Whatever strategies a company is pursuing, it must be able to react quickly and realign its strategic focus.

This article reveals the features of developing a marketing strategy for an enterprise. The development of a marketing strategy is a complex process that requires in-depth research of the state and development of the market, as well as an assessment of the position of the company that it occupies in the market. At the level of the enterprise as a whole, a general strategy is formed that reflects the general strategic line of development and a combination of its possible directions, taking into account the existing market conditions and the capabilities of the company. Strategy focuses on what the firm does and does not do, which is more important and less important in the current activities of the firm. Whatever strategies a company is pursuing, it must be able to react quickly and realign its strategic focus

When Coronavirus Disease 19 appeared in 2019, the public was renewedly worried about the spread of aeronautical and aerosolized viruses. Many contradictory dialogues on which types of personal safeguards defend dentists and patients better against viral exposure follow this issue. In this comprehensive analysis, we carry out a thorough and critical evaluation of face masks and face shields, some of the personal protections most widely prescribed against viral infection.
The roles and practises of most popular types of masks in odontology are described: operation masks, operative masks, and respiratory masks are filtered (also called N95s). Following this would be the crucial evaluation of masks used on the basis of an analysis of the recorded proven results in three main areas: the extent to which each type of mask is demonstrated to defend against airborne and aerosolized environments, the recorded possibility that masks are not acceptable and risk factors for both correct and incorrect use of masks1–3. Our examination finished with some realistic, evidentiary guidance for use in dentistry and dental clinics using this material.

In this research paper, the researcher wants to examine the artistic visual language of Indian terracotta Arts, which were conceptualized from Indus to contemporary. The investigator being associated with a concise history of sculpture or terracotta arts, is aware of circumstances in which artists of successive generations have struggled for the sociological and formal problems in innovation and terracotta art making. The main objective research paper is to present a concise history of Prehistoric to present contemporary times terracotta arts in India from different sates, as well as a comprehensive overview of developments in the material aspects of pottery and other terracotta from its origins in the early first century to the present. Terracotta the oldest medium and the most friendly medium form the time of Indus valley to the other states of India. this will help in introducing terracotta of different states in India, artists and craftsman has created wonder from clay in the form of toys, architecture, jewelry. Both traditional and contemporary innovations were observed in the light of the continuity between the terracotta method, i.e. its materials and methods of production in relation to its' form. In accordance with this study

The research is dedicated to the theoretical and economic justification for the impact of investment and innovation as an important factor in increasing economic efficiency.

Background: The inferior alveolar nerve block (IANB) is the most frequent regional anaesthesia technique used in dental procedures and has been reported to have the highest failure rates among dental undergraduates, interns and even, dental professionals. Hence, local anaesthesia has been formally taught in worldwide dental curriculum since the 1940s. This was when lignocaine was introduced as the safest anaesthesia medium for dental anaesthesia. Otherwise, dental anaesthesia was performed by Horace Wells in 1920s using cocaine. Purpose. This study is mainly aimed to examine the difference between Year 1 and Year 3 dental undergraduates towards perceived attributes of innovation diffusion theory and intention to use a Novel Local Anaesthesia Simulator Kit (LASK) in competently performing inferior alveolar nerve block in pre-clinical simulation. Methodology. A cross-sectional survey was conducted using questionnaire; and distributed to dental undergraduates. A total of 150 questionnaires were valid for data analysis. Results. The findings revealed that the perceived attributes of relative advantage, compatibility, observability and trialability were statistically different for both groups of students. However, results indicate that complexity construct for both non-clinical and pre-clinical groups of students were not statistically significant difference. Conclusion. The findings of this study will contribute to specific educational significance in the dental curriculum, especially in assessment of dental undergraduates’ clinical competence dental undergraduates at a more microscopic level.

This study aims to determine how to build a business strategy to mediate multidimensional entrepreneurial orientation as measured by the dimensions of innovation, proactivity and risk-taking in improving company performance (study on street vendors in Surakarta). The results of the research with path analysis test show that business strategy is able to mediate the multidimensional influence of entrepreneurial orientation as measured by the dimensions of innovation, proactivity and risk-taking. The results showed that all dimensions of entrepreneurial orientation had a significance value smaller than α = 0.05. While the results of the direct proactive effect have no significant effect on business strategy, innovation and proactive have no significant effect on the performance of street vendors {Pedagang Kaki Lima (PKL)} in Surakarta, Indonesia. So that the multidimensional influence of entrepreneurial orientation as measured by the dimensions of innovation, proactive and risk-taking on company performance is better indirectly with the business strategy variable as an intervening variable.

This article through the integration of the disciplines of engineering graphics and design technology education teaching methods contains characters illuminated. It of planned to actively use interdisciplinary integration, increase the effectiveness of education, analyze and implement it in practice and give high results. Teaching engineering graphics and design sciences in the classroom one of the main sources of organization is the need for integrated training that meets the requirements of the time.

A significant part of the ecosystem (biome) and natural landscape diversity of the Earth's temperate belt is represented in the Russian Federation. It is preserved due to the relatively low disturbance of the country's territory (up to 65% of the country's area, mainly in the Arctic, Siberia and the Far East, maintain a natural mode of functioning). The share of arable land in biomes reaches 40-50% in the forest-steppe and steppe, and in general, agricultural lands occupy in the biomes of the Russian Federation from 0% (tundra) to 85% (steppes).
The landscape diversity of the Russian Federation itself includes about 20 types of landscapes (arctic, subarctic, boreal (taiga), subboreal humid, semiarid and arid, subtropical, mountainous - alpine, glacial, etc. Swamp, floodplain, aquatic, shallow marine, etc.) and more than 350 types of landscapes. Among them, taiga (boreal) landscapes are leading in terms of area - 52%. Cold arctic and subarctic (plain and mountainous) occupy 21%. Mountain landscapes occupy 30–33%. The most developed, optimal for the development of agriculture, the territory of the forest-steppe and broad-leaved forests occupy 8%. The Convention on Biological Diversity (CBD) links the concept of "biodiversity" and "sustainable development".
It follows from the preamble of the Convention that biodiversity must be conserved not only for its own sake, but also for the use and enhancement of human well-being.
This has given rise to the concept of ecosystem goods and services that biodiversity provides and that can be critical to the needs for foodstuffs, health and healthy environmental needs.
In the National Strategy for the Conservation of Biodiversity of the Russian Federation, the main groups of life-supporting functions of biological diversity have been identified: production functions, environment-forming functions, informational and spiritual-aesthetic functions.

This article discusses ways to use interactive software in biology education. The types of interactive software used in teaching biology and the possibilities in preparing future biology teachers for professional activities are described. And also, it is devoted to the development of electronic teaching and methodological resources of educational institutions, improving mechanisms for the effective use of interactive software based on innovative approaches, methodological support for the organization of the educational process based on interactive software in the training system of future biology teachers, a system of professional competencies and mechanisms of cyclic diagnostics.