Online ISSN: 2515-8260

Keywords : transforaminal lumbar interbody fusion

To determine difference between radiological and functional outcome in TLIF surgery with use of BMP 2 VS without bmp 2 in adult patients

Dr. Mitul Mistry, Dr. Sandip Rathod, Dr. Bimal Modi, Dr. Manish Shah

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 395-400

Background: Bone morphogenetic proteins (BMP) are multi-functionalgrowth factors that
belong to the transforming growth factor beta (TGF-beta) superfamily. The purpose of the
study is to determine difference between radiological and functional outcome in TLIF surgery
with use of BMP 2 vs without BMP 2 in adult patients.
Methods: The present study evaluated data obtained between May 2016 and July 2017 on
patients in whom BMP-2 was used in conjunction with TLIF. 150 fulfilled the study criteria
whose mean age was 54.6 years [range 25–65 years]). Twenty-five patients (33.8%) had
previously undergone lumbar surgeries (discectomy, fusion, and decompression).
Result: Both groups had similar gender distribution and average age at surgery (48.9 ±
12.2years for the BMP group and 44.6 ± 13.7 years for the non-BMP group, p>0.05). As
expected, the BMP group had a shorter median follow-up time of 5.05 ± 7.10 years while the
non-BMP group was followed for a median of years 5.06 ± 12.6.
Conclusion: It is important that clinicians explain these findings to patients so that they can
make informed choices about the type of surgery they would prefer. The use of BMP safe and
effective in the context of TLIF procedures, and thoughtful discussion with patients about the
pros and cons of BMP utilization during surgery is recommended


Ashraf Yassin Amer; Ahmed Gamil Ahmed; Ahmed Samir Rady; Mohamed Ahmed Raaft; Mahmoud Mohamed Elbakry

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 309-324

This study assesses the difference between Minimally Invasive Transforaminal Lumbar
Interbody Fusion (MI-TLIF) surgery and conventional open TLIF surgery incases of
lytic spondylolisthesis regarding pain, disability, hospital stay and complications. Lytic
Spondylolisthesis patients may require fusion of one or more spinal segments. The
chances of achieving a successful lumbar spinal fusion have increased. TLIF technique
is gradually being accepted in these cases and widely used by most spinesurgeons.
Minimally invasive TLIF is a recent trend for spinal fusion. This is a prospective
randomized comparative study conducted from March 2016 to December 2018 that
included 40 patients with low grade lytic spondylolisthesis who underwent TLIF. 20
patients underwent MI-TLIF through percutaneous posterior lumbar pedicular screw
fixation, microscopic minimally invasive transform aminal discectomy and interbody
cage fusion (patients group A) and another 20 patients underwent conventional open
posterior lumbar pedicular screw fixation and TLIF (control group B). In our results,
bothsurgical techniques showed improvement in pain and function within 12 months
(follow up period), but group A showed statistically significant improvement in pain
and function in the first 3 months. Regarding blood loss, need for transfusion and
hospital stay, group A showed statistically significant better results. As a conclusion,
MI-TLIF is a better option in surgical management of spondylolisthesis especially in the
early postoperative period.