Keywords : GRA1
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 9, Pages 375-382
Toxoplasmosis is caused by infection with the parasite Toxoplasma gondii. It is one of
the most common parasitic infections in humans and is most typically asymptomatic.
However infection in a pregnant woman can cause severe and disabling disease in the
developing fetus. The presented study aimed to determination the correlation of Toxo-
IgA seroprevalence among pregnant women to various Toxoplasma antigens with the
serum IL-4 level. From the June 2017 to January 2018 ,300 pregnant women enrolled
in this study attended to Salahalden General Hospitals . The pregnant women were
examined for Toxo-IgA and determine their specificity for various Toxoplasma antigens
by using line immune assay and the serum IL-4 evaluated by using ELISA technique .
The rates of Toxo-IgA seropositive were 22 [7.33 %]. Considering the reactivity of
determined Toxo-IgA against various Toxoplasma antigens; the rates were 12[54.54%],
13[59.09%], 11[50.00%] ,14[63.63%] ,17[77.27%], 13[59.09%] ,11[50.00%] and 18
[81.81%] seropositive for Toxoplasma ROP1C, MIC3, GRA7, GRA8, p30 ,
MAG1,GRA1 and rSAG1 antigens respectively. Regarding to the total serum IL-4
level ,the highest rate of decreased serum IL-4 level among Toxo-IgA seropositive was
59.09%.In the presented study we concluded the highest rates of decreased serum IL-4
levels was 54.55% seen within Toxo-IgA seropositive for GRA7 and GRA1 antigens ,
and the rates of increased serum IL-4 level ranged from 5.88% to 9.09% within all
seropositive groups to various Toxoplasma antigens.