Online ISSN: 2515-8260

Keywords : Lichen planus

Association of lichen planus with metabolic syndrome–acasecontrol study in a tertiary care center.

Nishant Saurabh Saxena , Nimisha Saxena , Animesh Saxena, Harsh Sharma

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 421-428

Background: Lichen planus is an inflammatory papulosquamous dis- ease which affects skin and mucous membrane and cause metabolic derangements.
Methods: This is an hospital based case control study during a span of 2 year (Jan2018-Dec 2019) which includes 60 cases of lichen planus and 60 age and sex matched controls. Relevant clinical history and physical examination was done and collaborated with blood investigations. Diagnosis was made based on IDF criteria.
Results: No significant association can be established between lichen planus and metabolic syndrome ( p=0.278) Although prevalence of hypertension was higher in cases as compared to controls (36% vs. 26%, p=0.027) , TG levels (12% vs. 6%, p=0.030 and low HDLC levels (47% vs. 33%, p=0.039). No significant association was established between FBS and waist circumference with lichen planus.
Conclusions: Although no significant association can be established between lichen planus and metabolic syndrome but its components such as hypertension, TG and HDLC were found to be associated with LP as per the study. Therefore screening of these parameters in LP patients is necessary to avoid future complications in these patients.


Dr. Somya Singhal, Dr. Akansha Astik, Dr. Pragya Kushwaha

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 415-423

Background: LP (Lichen Planus) is a disease having unknown etiology, and is considered a
papulosquamous disease. The occurrence of lichen planus in children is an uncommon finding.
The data in previous literature concerning the clinical profile of children with lichen planus are
scarce and need further exploration with the majority of conducted studies being retrospective.
Aim: The present clinical study was conducted to assess the clinical profile of Lichen Planus in
the pediatricsubjects. The present study also evaluated the risk factors associated with childhood
lichen planus, if any.
Methods: The present study included 46 pediatric subjects of age less than 14 years and having
an either histopathologic or clinical confirmed diagnosis of Lichen Planus. The study was carried
out at LLRM Medical College, Meerut. For all the included subjects, detailed history,
investigations, and examinations were carried out.
Results:46 cases of childhood LP were included in the study and they constituted 1.2% of the
pediatric dermatoses. There were 25 males (54.34%) and 21 (45.65%) females with a male to
female ratio of 1.2:1. The age ranged from 6 months to 14 years with a mean age of 11.1 ± 4.6
years. The duration of the disease ranged from 15 days to 5 years with a mean of 9.2 ± 3.2
months. A history of recent hepatitis B vaccination (HBV) was found in 8 (17.4%) patients, and
exposure to X‑ ray radiation was seen in 5 (10.86%). A history of blood transfusion was present
in 1 (2.2%) patient. Classical LP was the most common variant, found in 30 (65.21%) patients,
followed by hypertrophic variant in 9 (19.56%) patients. Koebnerization was found in 31
(67.39%) of the patients. Oral mucosa was involved in 28.26% of patients, nail in 41.3% of
patients, and scalp in 8.69% of patients.
Conclusion: The present study concludes that childhood lichen planus shares a resemblance in
most of the aspects to the adult lichen planus. However, childhood lichen planus is still an underreported

Prevalence of oral, skin, and both oral and skin lesions of lichen planus: A cross-sectional study

Dr Moin Banday, Dr Snover Amin, Dr. Danish Qureshi

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 5431-5435

Background: Lichen planus (LP) is a pruritic, inflammatory skin, mucous membrane,
and hair follicle condition. It affects people of various ethnicities all over the world. 1.5
percent of men and 2.3 percent of women have oral LP. In some situations, it may be
inherited. The goal of this study was to determine the prevalence of oral, skin, and both
oral and skin lesions of LP in patients who visited a dental college's Department of Oral
Medicine and Radiology.
Material and methods: The prevalence of oral, skin, and oral and skin lesions in people
with LP was investigated in a cross-sectional study. We conducted a prospective study
for 18 months. All patients suspected of having LP were diagnosed based on clinical
presentation and histological investigation of mucosal and skin sample. SPSS (Statistical
Package for Social Sciences) software version 14 was used for statistical analysis. The
chi-square test was performed to determine statistical significance.
Result: There were 7,112 men and 8,544 females among the 15,656 patients who were
screened. LP appeared in 126 cases (0.80 percent). The prevalence of LP was found to
be higher in middle-aged adults (21-40 and 41-60 years old), with the lowest age being
14 and the highest being 67. There were no statistically significant differences between
genders in the skin LP group or the oral and skin LP groups, however there was a
substantial female preference in the oral LP group.
Conclusion: Oral LP was shown to be more common than skin LP, and both oral and
skin LP had a female predominance in this investigation.

Evaluation of Serum Interleukin-6 in Lichen Planus

Mohamed Metwalli, MD, Hoda. AIbraheem, MD, Hager Abu bakr MSc. FathiaKhattab MD

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 3603-3611

Background: Lichen planus (LP) is animmune mediated inflammatorydiseaseof skin and
mucous membranes without a clear etiology. Interleukin-6 (IL-6) is a pro-inflammatory
cytokinewith variousbiologicaland pathological impactson immunity, acute phase response
andinflammation. ExcessiveIL-6production can play a role in the pathogenesis of several
pathological conditionslike psoriasis.
Aim:This study aimed to evaluate serum IL-6 levels inLP patients alongwithassessment
ofitscorrelation with disease severity.
Patients and methods: Twenty-one adult patients with LP as well astwenty-one healthy adult
controls were enrolled in the study. The total score of LP severity was estimated for all
patientsby calculation of the affected body surface area in cutaneous LP patients and clinical
scoring system with visual analogue scale for pain assessment for oral LP.Serum IL-6 levels
were measured in all participants using enzyme-linked immunosorbent assay.
Results:The mean serumIL-6 levels were significantly higher in patients than controls (P <
.002). A positive correlation wasnoticed between serum IL-6 with both cutaneous LP (P
<0.004) and oral LP (P <0.005) severities.

The Association between Uric and Ascorbial Acid Serum and Lichen Planus Pathogenesis

Sara Mohamed Mohamed; Sahar Mohamed Abd El fattah; El-Sayed Mohamed Galal; HodaAbdeen Ibrahim

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 489-494

Background: Lichen planus (LP) is a common disorder whose etiopathogenesis is not clear.Recently, it has been suggested that increased reactive oxygen species (ROS) play important roles in the underlying mechanism of LP. Free radicals have an important involvement in the underlying mechanism of lichen planus and also various skin diseases. The aim of the study was to evaluate serum uric acid (UA) levels as a measure of the antioxidant defense status in lichen planus patients.
Methods: A case control study was performed on 17 patients with lichen planus and 17 healthy subjects as a control group. We estimated Serum level of uric acid and ascorbic acid using ELISA.
Results: The mean of serum levels of uric acid and ascorbic acid was lower in patient group compared to healthy group with no significant difference between the two studied groups.
Conclusion: Lichen planus pathogens are not specifically affected by antioxidants as uric acid and ascorbic acid. However, in addition to other interactive variables, the difference in the level of serum for these anti-oxidants between lichen planus patients and healthy subjectsalbight not important– may suggest their involvement.



European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 400-407

Lichen planus is an autoimmune disorder that primarily affects the body's skin and
multiple mucous membranes. In multicellular species, protein 53 and syndecan-1protein
play an significant role since they control the cell cycle and thus play a major role in
tumor suppression and cancer prevention. The p53 gene was therefore identified as a
"genome protector," referring to its role in preserving the integrity of genetic
information by preventing gene mutations. The purpose of this analysis was to study the
association between certain immune markers in lichen planus patients.
The aim of this study : Study correlation between some immune marker in patients with
lichen planus
Methods 'Thirty formalin-fixed , paraffin-embedded tissue pieces, diagnosed as Oral
Lichen planus(OLP), were included in the sample of this report.
Results: Evaluation of P53 Immunohistochemistry and Evaluation of syndecan-
1protein Immunohistochemistry Conclusion: the marker p53 expression is high in the
patient with Lichen Planus while the second studed marker syndecan-1 protein is less
than marker p53

Association Of Oral Lichen Planus And Thyroid Disease - A Case Control Study

Manthra Prathoshni.S; Muthukrishnan Arvind; Visalakshi Ramanathan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 3137-3149

Introduction: Lichen planus, is a chronic autoimmune, mucocutaneous disease affecting the oral mucosa besides the skin, genital mucosa, scalp and nails.The exact etiology of oral lichen planus is unknown. The disease most commonly affects middle-aged females. Oral lichen planus usually presents as white striations (Wickham's striae), white papules, white plaque, atrophic , ulcerative, erosive or as blisters. There is a well established correlation between oral lichen planus and liver disease. Opinion amongst researchers vary on terminology of lichen planus and lichenoid drug reaction . Recent literature reported association between lichen planus and thyroid disease.
Aim: The main aim of this study is to evaluate the association between oral lichen planus and thyroid disease and its prevalence amongst patients visiting our dental institute.
Materials and methods: 67 case sheets of patients, diagnosed with oral lichen planus between June 2019 and March-2020 were retrieved from the electronic database . Collected data were entered into the Excel sheet and was analysed using SPSS analysis.
Results: Results showed a positive association between oral lichen planus and thyroid disease, mainly hypothyroidism (7.46%). Females were more affected than males (53.7%).The erosive variant of oral lichen planus was more prevalent among the study population (44.7%). There was a positive correlation between predominant clinical variety of Lichen planus and site involved. The positive correlation between hypothroid state and lichen planus is also reported.
Conclusion: In conclusion, our study establishes an association between oral lichen planus and a coexisting thyroid disorder mainly hypothyroidism .