Online ISSN: 2515-8260

Keywords : MDA

Distal Femoral Fracture Fixation with Retrograde Nailing versus Plating: Femoral Alignment Outcome

Tarek AbdElsamad ElHewala, Alaa Ahmed Elngehy,Mohamed Khaled Engim , Osam Mohamed Metwally

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 3180-3188

Background:Distal femur fractures occur following high-energy impact in young
patients or low-energy injury in elderly patients with osteopenic or osteoporotic
bone.This study is aimed to compare the results of retrograde Nailing versus plating
technique in distal femoral fractures regarding both clinical and radiological
alignment. Patients and methods:This study was conducted on 18 patients with
distal femoral fractureswho divided into two groups; Group A treated by retrograde
femoral nail (RGN) and group B treated by Plating technique. All patients were
subjected to clinical and radiological measurements to assess the outcomes after
surgery. Results:Clinical measurements in normal limb was 4.66±1.32 in
retrograde nail group while it was 4.88±1.58 in plating group, the MAD in
fractured limp clinically was 5.38±1.89 in retrograde nail group while it was
6.48±2.31 in plating group. The radiological MAD showed significant difference
between the normal and operated side. Mechanical Lateral Distal Femoral Angle
(mLFDA) in fractured limb was 88.66±2.54 in retrograde nail group while it was
89.33±3.67 in plating group (P=0.663). Medial Proximal Tibial Angle (MPTA) in
fractured limb was 87.77±1.85 in retrograde nail group while it was 87.88±3.48 in
plating group. In spite of the excellent results in RGN group compared with group
(B), the overall results showed no significant difference statistically between the two
groups. Conclusions: Retrograde nailing is a good fixation system for fractures of
distal femur with better outcome in terms of range of movements, less infection rate
and early mobilization.

The impact of oxidative stress and some endogenous antioxidants on type 1 diabetes mellitus

Doaa Alaa Gheni; Jafar A. Al- Maamori

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 4295-4310

Type 1 diabetes is one of the autoimmune diseases and is characterized by the destruction of beta cells in the pancreas, which leads to a complete loss or deficiency of the insulin hormone. This breakdown in beta cells is the result of several environmental, genetic, and oxidative factors are considered among the factors accused of destroying beta cells, so this study is designed to evaluate the effect of some oxidative factors in insulin dependent diabetes patients. The study includes 80 patients with type 1 diabetes compared with 40 healthy individuals as control group. The results showed a significant increase in the levels of total oxidant status (TOS) and malondialdehyde (MDA) and Transferrin in diabetic patients and a significant decrease in the levels of superoxide dismutase (SOD) and glutathione reductase (GR) comparing with healthy control. The study also noted over expression (folding change) for COX 7B in T1DM patients. The study concludes that oxidative status and enzymatic and non-enzymatic endogenous antioxidants play an important roles in the breakdown of beta cells, and thus it is one of the suggested factors responsible for developing type 1 diabetes mellitus.

Evaluation Of Serum Antioxidant Enzymes In Oral Submucous Fibrosis And Oral Squamous Cell Carcinoma- A Clinical And Biochemical Study

Dr. Rakesh G Oswal; Dr. Nandan Rao K.; Dr. Prashant Mall; Dr. Ishita Grover

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 3205-3209

Background: The present study evaluated serum antioxidant enzymes in oral submucous fibrosis and oral squamous cell carcinoma. Materials & Methods: 30 cases of OSMF and 25 cases of OSCC of both genders. 30 healthy subjects were also enrolled. 6 ml of blood samples were collected with a tourniquet applied 1½-2 inch above the antecubital fossa. The collected blood was centrifuged and the plasma separated was analyzed for vitamin E, beta carotene, MDA. Results: The mean vitamin E level was 7.19 in group I, 6.52 in group II and 9.12 in group III. Beta carotene level was 70.3 in group I, 62.3 in group II and 114.5 in group III. MDA level was 9.16 in group I, 13.4 in group II and 2.91 in group III. The difference was significant (P< 0.05). Conclusion: There was increased level of MDA and decreased level of vitamin E and beta OSMF and OSCC patients.