Online ISSN: 2515-8260

Keywords : acute myocardial infarction

Serum Uric Acid Level in Predicting Outcome in Acute Myocardial Infarction: A Prospective Study from North India

Dr. P S Nayyer, Dr.Harinder Kumar, Dr.Atindra Narayan, Dr.Niraj Kumar, Dr. Rajesh Ranjan,Dr. Amit Johari

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 2575-2581

Background: In India, cardiovascular disease (CVD) is the main cause of morbidity and
mortality. According to recent trends, this group of disorders has expanded to younger
age groups as well. Cardiovascular illnesses are on the rise in India, affecting both men
and women in both urban and rural areas. The objective of this study was to analyse
serum uric acid levels correlate these values with Killip class in patients of acute MI.
Materials and Methods: Study was prospective type conducted at Dr. Baba
SahebAmbedkar Medical College and Hospital, Rohini, New Delhi from September
2016 to August 2017. A total of 100 patients of acute MI admitted to the ICCU, falling
into inclusion criteria were enrolled. Information was collected through a pre tested
and structured proforma for each patient. Also, physical examination and laboratory
investigation with special reference to Killip classification of heart failure was carried
out. During data analysis, a p value of <0.05 was considered statistically significant.
Results: Mean age of population 54.77 years. This study population had male
predominance (69.0%). In our study out of 100 patients 85 (85%) patients were STEMI
and 15 (15%) patients were NSTEMI. Mean uric acid on day 7 in patients with Killip
class I was 4.72 mg/dl and subjects with Killip class II was 6.62 mg/dl. In multivariate
logistics regression no factors were significantly affecting mortality after adjusting for
confounding factors.
Conclusion: From our study, we conclude that serum uric acid levels are correlated
with Killip class and patients with higher Killip class have higher serum uric acid levels
in acute myocardial infraction.

Clinical and hemodynamic efficacy of prehospital thrombolysis in acute coronary syndrome with ST elevation

Kenjaev S.R

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 10, Pages 2327-2331

According to the World Health Organization (WHO), cardiovascular disease (CVD) is the leading cause of death and disability in countries around the world, with ST segment elevated myocardial infarction (STEMI) leading the way. Despite advances such as the widespread introduction of many effective drugs, angioplasty and surgical treatments into clinical practice, CVD kills 17.3 million people annually, accounting for 30% of all deaths worldwide. This figure is projected to increase to 23.6 million by 2030. In the world, including in Uzbekistan, over the past two decades there has been an increase in morbidity and mortality from cardiovascular pathology.

Plasma atrial natriuretic peptide level and serum electrolyte status among patients with acute myocardial infarction complicated with cardiac arrhythmia

Prof. Abdul - Aziz Ahmed Aziz; Dr. Abdul-Hassan M. S.; Dr. Mohammed K. B.

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 4352-4360

Objective: Acute myocardial infarction is a leading cause of morbidity and mortality worldwide. Electrolyte imbalance among patients with acute myocardial infarction is not uncommon. The aim of the present study is to assess the status of serum sodium and potassium and plasma atrial natriuretic peptide level among patients with acute myocardial infarction complicated with cardiac arrhythmia.
Design: A case control study.
Setting: Ibn-Sena hospital/ Mosul-Iraq.
Participants: the study included 92 patients with acute myocardial infarction, divided into 2 group; Group I, included 44 patients with uncomplicated acute myocardial infarction; group II, included 48 AMI patients complicated with cardiac arrhythmia. The study also included 50 apparently healthy volunteers as a control group.
Methods: Plasma level of atrial natriuretic peptide, serum concentration of sodium, potassium were measured.
Results: The results of the study showed a significantly low serum sodium and potassium concentration in patients with AMI (p< 0.0001 and p<0.0001) in comparison with control group. The means of plasma level of atrial natriuretic peptide was significantly higher in patient with acute myocardial infarction in comparison with control group (p< 0.0001), atrial natriuretic peptide level was also higher in patient with complicated acute myocardial infarction in comparison with uncomplicated group (p< 0.0001). A significant negative correlation was observed between plasma atrial natriuretic peptide and serum sodium concentration in patients with uncomplicated acute myocardial infarction (r =-0.825, p<0.0001) and complicated acute myocardial infarction (r =-0.884, p<0.0001). Conclusion: In acute myocardial infarction, electrolytes imbalance is a common fining and usually associated with a variety of cardiac arrhythmia, plasma level of atrial natriuretic peptide significantly increased in patients with acute myocardial infarction and negatively correlated with serum sodium concentration.

Acute Myocardial Infarction And Its Associated Therapy

Amandeep Kaur

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4007-4014

Acute myocardial infarction (AMI) is one of the common diseases in developing countries.(Sathisha et al., 2011)It is generally known as a heart attack, which occurs when there israpid blockage in flow of blood in one or more of Coronary arteries and decreases the supply of blood to heart muscle, leading to necrosis in which enormous death of cells andpermanent damage occur. If blockage is severe, then heart faces cardiac halt. This is very common because ofblockage occur in coronary artery following splitting of atherosclerotic plaque in which uneven collection of lipids,more commonly cholesterol and fatty acid as well as WBC’s specifically macrophagesoccur in walls of artery.AMI is one of an exampleof coronary artery disease, that results into greater than 2.4 million expiries in USA, greater than 4 million expiries in Europe and northern Asia,(Nichols, Townsend, Scarborough, & Rayner, 2014) as well as greater than one third of deaths in advanced countries per year. In this review article, the pathophysiology of acute myocardial infarction along with some uses of drugs is discussed.