Online ISSN: 2515-8260

Keywords : Ulcer

Comparative study of staplersvs simple interrupted vs sub-cuticular method of skin closure of surgical wounds

Dr. Ankit Mohan Das, Dr. JagadambaSharan, Dr. MohitBiswas

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 1926-1933

Aim: To compare staplers vs simple interrupted vs sub-cuticular method of skin closure of
surgical wounds.
Material and method:The present randomized prospective study was conducted in the
Department of Surgery at Rohilkhand Medical College and Hospital, Bareilly from January
2020 to October 2021 among 150 subjects who underwent surgical procedures. Equal number
of patients was allotted to 3 groups by random envelope allocation method i.e. Group
A(Stapled skin closure), Group B(Interrupted skin closure) and Group C(Sub cuticular skin
closure). Following the completion of closure, an antiseptic medicated cream was applied
followed with a protective dressing for the first 24–72 h. Subcutaneous Drains were placed in
selective cases according to infection and were kept till the drain content was minimal. All
patients were given IV antibiotics for 5–7 days postoperatively. The closures were removed
after an interval of 10–14 days, first removing the alternate sutures and then the remaining
sutures after few days and pain on removal was recorded using VAS.
Results: Postoperative pain score at discharge was least in sub-cuticular group followed by
stapled and interrupted skin closure group, though statistically there was no difference.
Conclusion: In this we found that time required for skin closure (in seconds) was least in
stapled skin closure group while pain and POSAS score was minimum in sub-cuticular skin
closure group. Wound infection was present maximum and minimum among sub-cuticular
and interrupted skin closure group respectively

Role of Parenteral Amino Acid in Patients of Diabetic Foot Ulcer

Dr. Ankit Mohan Das,Dr. Jagadamba Sharan, Dr. Mohit Biswas

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 2071-2079

Aim: To analyse the role of amino acids among subjects with type 2 diabetes having foot
Material and method: The present study was conducted in the Department of Surgery,
Rohilkhand Medical College and Hospital, Bareilly from February 2020 to March 2021. The
study comprised of 60 patients, aged 18 years and above, suffering from diabetic foot ulcer.
Patients were divided into two groups i.e. group A and B. Patients of group A continued to
take diabetic diet as they were taking before while patients of group B were given IV amino
acid (200ml) on alternate day till 15th day in addition to the diet they were taking before.
Ulcers of all patients were properly cleaned and dressed under aseptic condition with normal
saline and povidone iodine everyday, wound debridement was done as required. Ulcers were
assessed on day 0, 5, 10 and 15.
Results: Mean cholesterol increased in group A while it decreased in group B at different
intervals with statistically insignificant difference as p>0.05. At the end of study, normal
healing was found among 26.67% and 66.67% of the subjects in group A and B respectively.
Major haematoma was reported only in group A and that among 10% of subjects. Hence
healing was observed better among group B subjects.
Conclusion: It can be concluded from the results that among subjects with diabetic foot
ulcers, amino acid administration leads to better healing and satisfaction among the patients.
Therefore, amino acids supplement should be given to diabetic foot ulcer subjects

A prospective study on the treatment of chronic non-healing ulcers using autologous platelet rich plasma

Neharika, Brajesh Pathak, Sanjiv Bhatia, Ravi Pratap Singh Rajey

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 9945-9953

Aim: To assess the effect of Platelet Rich Plasma (PRP) in non-healing ulcers.
Material and methods: It was a hospital based prospective cross-sectional &
observational study between July 2020 to June 2021, at Hind institute of medical
sciences, Safedabad, Barabanki. The history and examination were done bedside. In
cases where the condition of patients doesn’t warrant giving history, their relatives or
attendants were interviewed. A predesigned pretested semi-structured questionnaire
was filled by the interviewer. Data was entered in Microsoft Excel sheet. The study area
was General Surgery, Orthopaedics& medicine department, of Hind Institute of
Medical Sciences, Safedabad, Barabanki.Pus culture and sensitivity were sent then after
cleaning the wound with normal saline and betadine solution, already centrifuged
platelet rich plasma was injected subcutaneously inside, in the periphery of wound and
spread over floor of ulcer then dress with non-absorbent dressing. 1st dressing was
changed on the 3rd day of injection then dressing was changed on every 7th day.We
evaluated the effect of 1 dose of platelet rich plasma injection efficacy in wound/ulcer
healing & reduction in wound/ulcer size and follow-up by visual inspection.
Results: At admission, the mean wound area was 388.6±25.35 mm2 which was reduced
Furtherreductionwasobservedat 14th day (49.66%) and 21st day (64.40%) and these
reductions were statisticallysignificant (p value <0.001).At 21st day the % change in
volume was maximum for venous ulcer (69.25±4.43 %) and minimum for post
traumatic (65.27±9.11 %). No significant difference was found in % change in volume at
21st day among various ulcer types (p value =0.336).
Conclusion: Based on this study observation and result, we proposed that platelet rich
plasma is a safe bio-compatible, cost-effective, less time-consuming procedure and does
not require sophisticated equipment.

Study of efficacy of superoxidised solution and gel (microdacyn) in the treatment of diabetic foot ulcer

Bhupinder Singh Walia, Pankaj Dugg, Navjot Singh, Sanjeev Sharma, Babu Lal Sunkaria

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 608-617

Introduction: Diabetic foot and diabetic ulcers are common complications of diabetes mellitus.
It affects daily life of patients and lead to amputations. The study was conducted to see the
effect and role of superoxidised solution and gel (microdacyn) in promoting the healing and
treatment of diabetic foot ulcer.
Material &Methods: The wound site was cleaned with normal saline followed by application
of superoxidised solution for 30 seconds and then followed by application of wound care
hydrogel. Observations were made during dressing and examination of the patients/ wounds
was done on the day 7,14,21,28 and at follow-up of 15 days. Rate of contraction of wound is
measured in cm2.
Results: Mean age of patients in the study was 50.0687±11.85 years with equal male to female
ratio. Superoxidised solution provides good wound healing and mean hospital stay was
10.49±4.24 days. Significant reduction of wound is seen in cases with short duration of ulcer
and short duration of diabetes (p<.05).
Conclusion: Superoxidised solution was associated with faster healing of ulcers without any
major complications, proving SOS to be safe and efficient as a wound care product in the
management of lower limb ulcers.

Morphofunctional Characteristics Of The Oral Mucosa Of Experimental Rats In Experimental Carcinogenesis

Alisher I. Khazratov; Jasur A. Rizaev; Nataliya Ye. Lisnychuk; Gulsara Dj. Reimnazarova; Aziz S. Kubaev; Kamronbek J. Olimjonov

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 227-234

Diseases of the gastrointestinal tract are often accompanied by changes in
the oral cavity. This is largely due to morphological and functional unity of the mucous
membrane of the mouth and entire digestive tract. According to numerous publications in
recent years, at the end of the XX-beginning of the XXI century, there is a significant
increase in the number of people suffering from cancer of the colon and rectum. This
localization accounts for 15% of all initially diagnosed tumors of all localizations (30% of
them are represented by rectal cancer).


Rizaev Jasur Alimdjanovich; Khazratov Alisher Isamiddinovich; Lisnichuk Natalia Evgenyevna; Olimjonov Kamronbek Jasur ugli; Reimnazarova Gulsara Djamalovna

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 666-672

Recently, there has been a significant increase in the number of cancer diseases worldwide. Mortality from malignant tumors is second only to pathologies of the cardiovascular system. Oncological diseases take many lives not only among the elderly, but also among the relatively young generation.