Online ISSN: 2515-8260

Keywords : subthalamic nucleus

Role Of Increasing Levels Of The Hormone Cortisol In Cognitive Impairment In Parkinson's Disease: Vascular Parkinsonism

Gulnora Sattarovna Rakhimbaeva; Dilshoda Turdikulovna Akramova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 2987-2994

This article is based on a review of the literature and recent clinical studies on changes in plasma cortisol hormone concentrations in cognitive impairment in Parkinson's disease. The article presents the reasons for the relationship between cognitive impairment in Parkinson's disease, in particular vascular Parkinsonism and neurodegenerative diseases, as well as the results of neuropsychological tests.
Methods: We studied the level of morning plasma cortisol in 68 patients with Vascular Parkinsonism (VP) who were hospitalized in 1st neurology department of TMA in the period from 2015 to the present.The relationship between increased morning plasma cortisol and cognitive impairment was determined.The results of the study were statistically analyzed.Cortisol was determined in all blood samples of patients of the Main and Control groups.The control group consisted of 47 volunteers.
Results: Normal levels of cortisol were observed in 20 patients (29%) with vascular parkinsonism,, moderate increases in cortisol were observed in 37 patients (54.4%), and elevations in cortisol were observed in 11 patients (16.1%). Was determined the relationship between the value of cortisol and the assessment of cognitive impairment.In the main group, a statistically significant moderate inverse correlation was determined between plasma cortisol level and cognitive impairment in VP. When studying cortisol levels in VP, its significant increase is noted than in the control (p <0.05).
Conclusion: Increased levels of the hormone cortisol in Parkinson's disease play an important role in cognitive impairment and during the course of the disease and affect the effectiveness of VP therapy.

Computer Analysis of Local Field Potentials of MER Data with STN Deep Brain Stimulation in Parkinson`s Disease

Anji Reddy Dabbeta; Narsimha G; Venkateshwarla Rama Raju

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 2405-2414

The local field potentials, i.e., the electrical-potentials of the deep brain stimulations (DBS) and micro electrode signal recordings of STN-neurons adjoining and contiguous DBS leads can vivid to give pragmatic rejoinder or snap therapeutic-surgical STN-DBS. Nevertheless, predictable square (conservative) DBS lead-electrodes amid four cylindrical macro/electrodes (for macrostimulations) likely under-sample the spatial circulation of sinks and sources in a given area of the brain. This study gives the exploration of the power-spectral-density (PSD) and spatial-feature dimensions of LFP-activity in primate subthalamic-nuclei (STN/or s-nuclei) and globus pallidus internus (GPi) by means of unendingly 32embedded-channel directional DBS-array-electrodes. The waveforms of s-nuclei and GPi were acquired as of directional-DBS-micro electrode-arrays in the latent or quiescent state and in a reach-and-retrieval task in two-primates in adolescent, naïve and immature (raw) animal Parkinson conditions. The potentials of signal acquisitions recordings were evaluated amongst bipolar-pairs of micro electrodes using personage and agglomerative (bunched) electrode configurations, with the latter mimicking the cylindrical macro electrode (for macro stimulations) arrangements/specifications employed in the present - current clinical settings of field-potentials signal acquisition. Signal recordings from these DBS-electrodes shown that, β-oscillatory frequency fluctuations have spatial-finger-prints in s-nuclei and GPi, and that these fluctuations were muted when clustering the electrode contacts together to create cylindrical macro electrodes alike in parallel and in