Online ISSN: 2515-8260

Keywords : streptokinase


Comparative evaluation of complications and mortality in ST-segment elevation acute myocardial infarction (STEMI) in diabetic and nondiabetic patients

Dr. Shakeel Akhter

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 1183-1187

Background: Diabetes is a universal problem and is becoming a major concern at old age
especially in obese people and in people with sedentary life style. The present study was
conducted to assess complications and mortality in ST-segment elevation acute myocardial
infarction in diabetic and non-diabetic patients.
Materials & Methods:160 consecutive patients of diabetic (group I) and non-diabetic
(group II) having acute ST-segment elevation myocardial infarction (STEMI) of both
genders were included. Treatment was given to all patients.
Results: Age group <44 years had 15 diabetic and 10 non- diabetic, 45-54 years had 25
diabetic and 12 non- diabetic, 55-64 years had 10 diabetic and 20 non- diabetic and >65
years had 40 diabetic and 28 non- diabetics. The site was anterior in 26 and 20, inferior in
38 and 40, inferior+ right ventricular in 20 and 10 and lateral in 6. Mortality was seen in
those in which streptokinase was given in 7 and 3 and streptokinase not given in 15 and 10
in group I and group II respectively (P< 0.05).
Conclusion: With streptokinase administration there was reduction in mortality in diabetic
as well as in non- diabetic. However, diabetics not on streptokinase had higher mortality as
compared to non- diabetics.

MANAGEMENT OF PEDIATRIC EMPYEMA WITH INTRAPLEURAL STREPTOKINASE : RANDOMISED CONTROL TRIAL

Dr. Abhijit shinde; Dr. Sunil NathaMhaske; Dr. Ramesh Kothari; Dr. Shreya Bhate

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 5712-5720

Parapneumonic pleural effusions may occur in 36–57% of patients with pneumonia and about 15–20% of this accumulated fluid becomes infected resulting in empyema [1,2)Empyema generally occurs in children after pneumonia of acute bacterial origin and it is generally associated with significant morbidity and mortality.Injection of various fibrinolytic agents like streptokinase, urokinase in the intrpleural space are increasingly being used for the management of such conditions.(7-10)The main aim of this study was analysing role of adding intrapleural streptokinase in the management of childhood empyema.Methodology:The present retrospective study was conducted in our Institute during a period of 2 years. The study consisted of 20 subjects that were admitted to the hospital with the complaint of pneumonia complicated by empyema.. Chest tube placement were done by pediatricians.Half of the patients received intrapleural streptokinase. The dose of streptokinase was 2,50,000 U in 100 ml of saline.The criteria for comparison were - duration of chest tube drainage, stay in hospital, fever and decrease in incidence of hospital stay were considered as successful treatment.All the data was arranged in a tabulated form and was analysed using Epi info software version 7.1.2. Chi square test and student t test was used for comparison. Probability value of less than 0.05 was considered significant. RESULT: The study enrolled total of 20 subjects, out of these 10 belonged to conventional group and 10 were administered intrapleuralstreptokinase.Both groups compared &There was no significant difference in the variables between the two groups as the p value was more than 0.05. CONCLUSION: From this study it is clear that addition of intrapleural streptokinase along with the conventional therapy provides no special benefit.In complicated cases fibrinolytics can be used as additional therapy.