Keywords : Cytokine storms
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 1, Pages 2551-2561
The n-CoV is a recent pandemic globally raising serious concerns on its exorbitance in both infection, transmission and mortality rate. It is an infectious disease driven by uncontrolled immune mediated inflammatory disease resulting in cytokine storms and acute respiratory respiratory syndrome. The virus affects the respiratory system and other organ systems and lower respiratory tract. Its initial symptoms include dry cough, nausea, fever, sneezing. In the virus and host interactions, both humoral and cellular immune response seem to play a vital role. Innate immunity is the first line of defence against virus invasion. Adaptive immunity also plays an important part in viral clearance via activated cytotoxic T cells that destroy virus-infected cells and antibody-producing B cells that target virus-specific antigens. With no proper medication to control the covid disease, researchers have implemented various immune mediated mechanisms to curb the viral replication and further establishment of the disease. This review thus highlights on the various immune-modulating mechanism implemented against covid disease with its limitations and challenges.