Online ISSN: 2515-8260

Keywords : Gene

Optimization Of Molecular- Genetic Methods For The Determination Of Resistance Markers Using Genotyping Of Actn3 And Ace Genes

Berdieva Dilnavoz Toshkan kizi; Bakieva Gulnoza Habibullayevna; Abdusattarova Sagdiana Sobitjanovna; professor Abdullaeva Muborak Makhmusovna; professor assistent Gazieva Zebunniso Yusubjanovna

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 10, Pages 67-74

Recently parents want their children to be busy with a particular kind of sport. Adults often decide on this issue, based on their own desires. But still, we must remember that, first of all, it is necessary to focus on the child's abilities and capabilities. Physical culture and sports are different things, and they pursue different goals: they are engaged in physical culture in order to strengthen their physical condition and be healthy, and sports are also for the sake of victories, achievements, and results. In humans, more than two hundred genes are known that are associated with endurance, speed and strength. Usually, the reason for differences (polymorphism) of genes is the replacement of individual nucleotides in the DNA molecule, leading to a change in the properties of the gene.
The main advantage of molecular genetic methods is that a person’s behavioral activity is shown to be hereditary, and early diagnosis reveals a highly informative assessment of the possibility of physical development. A distinctive feature of this diagnosis is the ability to identify hereditary trends, the development of factors of occupational diseases, determining the physical performance of a person and reducing the quality of his life.

Modern Approaches To Vitiligo Treatment

Mukhabbatkhon Yokubova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 1005-1007

This article discusses modern approaches to treating vitiligo and lists the methods of treating vitiligo.It was used to treat vitiligo in 28 patients. Most of them enjoyed of clinical condition. The preparation was well tolerated and produced no adverse effects.

Complex Approach To The Diagnosis Of Cystic Fibrosis In Children

Shohsanam Bahromovna Uzakova; Furkat Mukhitdinovach Shamsiev; Nargis Khayrullaevna Mirsalikhova; Nigora Davlyatovna Azizova; Rano Anvarbekovna Musajanova; Nilufar Irgashevna Karimova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3003-3007

The aim of the study was to study the clinical and diagnostic features of cystic fibrosis in children in Uzbekistan. The study included 120 patients with cystic fibrosis at the age of 0 months. up to 14 years old, who were inpatient treatment in the department of pulmonology, pathology of early age and gastroenterology. In children with cystic fibrosis, the main clinical symptoms of the bronchopulmonary system were: cough, shortness of breath, oral wheezing, lethargy and loss of appetite. Upon admission to the hospital, the general condition of the patients was most of all regarded as severe. The most common causative agents of the disease exacerbation were S. aureus - 32%, Str. pyogenus - 26%. Based on the results of the study, the frequency of mutations in the CFTR gene and their influence on the nature of the course were determined. A significant role has been revealed for the 4 most common gene mutations in Uzbekistan, CFTR-F508del, CFTR-2143delT, R709X, Y569D.

A Review on Smart Nanoparticles Drug Delivery System for Targeted Genes

Simarpreet Virmani; Bhupinder Kaur; Vishal Dubey; Jayesh Yadav

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4665-4676

Nanotechnology has laid the foundation to nanomedicine production and still appears the cornerstone for ongoing global medical studies, since at nanometric scale the physical properties of materials vary, resulting in innovative magnetic, biochemical, visual and electrical characteristics. In addition to the huge amount of funds and capital, the emergence of new medicinal products against the changed pathological condition of our bodies is also challenging in view of maximum rate of failure. The modifications with in structures of products in nano particle form, altered the way of diagnosis and treatment of destructive human diseases by using medicines capable in effective management by modifying the step of discharge, delivery and disposal in the body. Smart nanoparticles are such one of the most demanding nano systems for drug delivery to targeted genes that can overcome the problems during treatment itself. Present review paper discussed the types and uses of various types of response-based smart nanoparticles to drug delivery practices.