Online ISSN: 2515-8260

Keywords : Disease activity

Vitamin D status and its association with disease activity in early rheumatoid arthritis in rural population of central India

Granth Kumar, Vidya Sagar Ram,Pankaj Kumar, Amit Varshney

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 648-652

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease
characterized by joint swelling, joint tenderness, and destruction of synovial joints,
leading to severe disability and premature mortality. Early rheumatoid arthritis is
defines as “RA with duration of disease/symptoms of disease < 6 month.”
Aim:To study serum vitamin D level in newly onset rheumatoid arthritis patients.
Methodology: It is a Case-control study, all patients fulfilling revised American College
ofRheumatology criteria/EULAR criteria(2010) for Rheumatoid Arthritis being
attended to in therheumatology clinic, Tools like Oral questionnaire, History &
Clinicalexamination,laboratory equipments will be used.Sample size is 45 cases and 45
controls, complying with inclusion and exclusion criteria.
Result: The study suggested that, mean value of Clinical Disease Activity Index (CDAI)
of RA was 12.24±8.05 in cases and 2.89±0.83 in control, DAS28 Score was 4.24 ± 1.07 in
cases and 3.00 ± 0.37 in control, it showed statistically significant association between
serum Vitamin D3 level with CDAI and DAS28 Score in rheumatoid arthritis patients.
Conclusion: The study results suggest that the inverse relationship between serum
Vitamin D levels and RA disease activity.

Impact of sex hormone fluctuations on functional health status and menopause rating scale among postmenopausal RA patients

Essam Tawfik Atwa; Hisham Mohamed Omar; Asmaa Amin Mohamed

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 2390-2400

Introduction: Women with RA have higher grades of disease activity and more declines in health status than men with RA; this recommends a relationship between estrogen and disease activity and severity.
Aim: Our aim was to detect the effect of sex hormone fluctuations and menopause on functional disability and quality of life of postmenopausal RA patients.

Neutrophil Lymphocyte Ratio And Platelet Lymphocyte Ratioassociated With Disease Activity In Patients With Systemic Lupus Erythematosus

Ismunandar .; Femi Syahriani; Faridin HP; Syakib Bakri; Hasyim Kasim; Tutik Harjianti; Sudirman Kat; Haerani Rasyid; Arifin Seweng

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 978-984

Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease with no well-known cause. The search for simple laboratory indicators is essential to assess the disease activity of the SLE. Currently, the Neutrophil Lymphocyte Ratio (NLR) and Platelet Lymphocyte Ratio (PLR) are widely used as markers of the inflammation.
Methods: A cross-sectional analytic study involving 35 patients who met the criteria by Systemic Lupus International Collaborating Clinics (SLICC) 2012 was conducted during August 2019 until June 2020. The samples were obtained from outpatients and inpatients of the Rheumatology Clinic at WahidinSudirohusodo hospital and its collaborating hospitals. The data of the value of neutrophils, lymphocytes, platelets and disease activity were collected using the Mexican Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI).
Results: Of 35 patients with SLE, all were women aged 18-51 years. The result shows that there is a significant relationship between NLR and MEX-SLEDAI scores (p <0.000). Also, PLR is significantly associated with MEX-SLEDAI scores (p <0.000).