Online ISSN: 2515-8260

Keywords : disease activity


Impact of sex hormone fluctuations on functional health status and menopause rating scale among postmenopausal RA patients

Essam Tawfik Atwa; Hisham Mohamed Omar; Asmaa Amin Mohamed

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 2390-2400

Introduction: Women with RA have higher grades of disease activity and more declines in health status than men with RA; this recommends a relationship between estrogen and disease activity and severity.
Aim: Our aim was to detect the effect of sex hormone fluctuations and menopause on functional disability and quality of life of postmenopausal RA patients.

Neutrophil Lymphocyte Ratio And Platelet Lymphocyte Ratioassociated With Disease Activity In Patients With Systemic Lupus Erythematosus

Ismunandar .; Femi Syahriani; Faridin HP; Syakib Bakri; Hasyim Kasim; Tutik Harjianti; Sudirman Kat; Haerani Rasyid; Arifin Seweng

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 978-984

Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease with no well-known cause. The search for simple laboratory indicators is essential to assess the disease activity of the SLE. Currently, the Neutrophil Lymphocyte Ratio (NLR) and Platelet Lymphocyte Ratio (PLR) are widely used as markers of the inflammation.
Methods: A cross-sectional analytic study involving 35 patients who met the criteria by Systemic Lupus International Collaborating Clinics (SLICC) 2012 was conducted during August 2019 until June 2020. The samples were obtained from outpatients and inpatients of the Rheumatology Clinic at WahidinSudirohusodo hospital and its collaborating hospitals. The data of the value of neutrophils, lymphocytes, platelets and disease activity were collected using the Mexican Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI).
Results: Of 35 patients with SLE, all were women aged 18-51 years. The result shows that there is a significant relationship between NLR and MEX-SLEDAI scores (p <0.000). Also, PLR is significantly associated with MEX-SLEDAI scores (p <0.000).