Online ISSN: 2515-8260

Keywords : neutrophil-lymphocyte ratio

Correlation of CD4 Count andNeutrophil-Lymphocyte Ratio in Human Immunodeficiency Virus-Acquired Immunodeficiency Syndrome (HIV-AIDS)Patients

Kartika Handayani; Sudirman Katu; Syakib Bakri; Risna Halim; Andi Makbul Aman; Haerani Rasyid; Hasyim Kasim; Arifin Seweng

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 985-993

Background: Human Immunodeficiency Virus (HIV) is an RNA virus that causes a decrease in the immune system and destroys specific white blood cells called T-helper lymphocytes or Cluster of Differentiation 4 (CD4); CD4 is a parameter in HIV-AIDS patients while NLR is a simple parameters that were used to assess inflammatory status.
Purpose: This study aims to determine the relationship between CD4 and NLR levels in HIV-AIDS patients.
Methods: This is an observational study with a cross-sectional design conducted in September 2019-September 2020. The study populations were all HIV patients that hospitalized and outpatient at Dr. Wahidin Sudirohusodo Hospital and his network hospital. Data were analyzed descriptively to found out the association between CD4 and NLR levels in HIV-AIDS patients using the Spearman trial.  Results: A total of 150 subjects, consist of 62 (41.3%) subjects at age 30-39 years, 122 (81.3%) male subjects, 108 (72%) subjects who had PEM nutritional status, and 102 subjects (68%) subject with CD4 count <50. Based on the Spearman test, there is negative correlation of CD4 and NLR in HIV-AIDS patient.
Conclusion: There are significant negative correlation between CD4 and NLR in HIV-AIDS patients at Dr. Wahidin Sudirohusodo Makassar, which higher NLR correlates with the lower value of CD4..

Acomparative analysis of neutrophil to lymphocyte ratio in chronic obstructive pulmonary disease patients and healthy individuals

Dr. Dipti mohapatra; Dr. Manasi behera; Dr.tapaswini mishra

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 824-831

Background/aims: COPD is among the significant health complications in entire world; studies have shown that there is systemic inflammation with pulmonary inflammation in case of COPD. To detect the systemic inflammatory response, neutrophil lymphocyte ratio (NLR) in peripheral blood which is important biomarker. NLR hasn’t been studied in patients having chronic obstructive pulmonary disease (COPD). Current study was targeted to determine the importance of NLR as inflammatory marker in patients with COPD.
Methods: The neutrophil and lymphocyte count in the peripheral blood was found out from blood count (CBC) reports. The NLR was determined by dividing neutrophil count from lymphocyte count. COPD patients were diagnosed with Spirometry. Then the NLR was compared in patients having stable COPD (n = 50), and healthy controls (n = 50.
Results: The neutrophil count was considerably greater in COPD patients matched with the healthy individuals (p < 0.001) whereas the lymphocyte count was suggestively lower in patients having COPD patients when compared to perfectly healthy individuals (p < 0.001).NLR values were considerably higher among patients with stable COPD patients than controls (p < 0.001). There were no noteworthy variance in the total leucocyte of COPD patients and healthy individuals.
Conclusion: It is concluded that the increase in the neutrophil-lymphocyte ratio in COPD patients compared to healthy individuals may be an indicator of systemic inflammation in patients with COPD.