Online ISSN: 2515-8260

Keywords : Carcinoma


Clinicopathological study of abnormal uterine bleeding in perimenopausal women attending a tertiary care district hospital

Dr. Gayathri BN, Dr. Mallikarjun A Pattanashetti, Dr. Somashekar HK

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 1759-1764

Background: Abnormal Uterine Bleeding (AUB) is defined as any bleeding that does not correspond with the frequency, duration or amount of blood flow of a normal menstrual cycle. Endometrial biopsy is important in perimenopausal age group women (40-55 years) to rule out endometrial pathology and malignancy. This study was done to assess Clinicopathological aspects and different histopathological patterns related to Abnormal Uterine Bleeding as no studies have been done in this region of Karnataka, India.
Methods: This is a cross sectional study done from 2019 to 2020. All female patients in the perimenopausal age group presenting with symptoms of AUB were included. Patients less than 40 years of age and endometrial tissues inadequate for opinion on microscopy were excluded. Relevant history and clinical data regarding pattern and duration of abnormal uterine bleeding was retrieved. Endometrial biopsy tissues was processed and stained by H&E. The diagnosis was done and results analysed.
Results: Present study included 94 biopsies of which 6 biopsies were inadequate for opinion. The most common age group presenting with AUB was 40-45 years (53.40%). The most common symptom was menorrhagia. The commonest histopathological pattern among all the perimenopausal age was disordered proliferative endometrium followed by simple hyperplasia without atypia. Other patterns were proliferative endometrium, secretory endometrium, simple hyperplasia, carcinomas etc. The commonest etiology of AUB was Dysfunctional Uterine Bleeding (46.59%) followed by Endometrial hyperplasias. (23.86%)
Conclusions: Correlation with clinical history, radiological investigations along with endometrial biopsy establishes etiology and diagnosis for patients with AUB.

Fibro-epithelial Hyperplasia Mimicking Oral Squamous Papilloma in an 8-year-old child - A Rare Case Report

Dr Ellana Jermiah Joseph, BDS; Dr Razia Haidrus, BDS; Dr Anupama Nayak P, MDS; Dr. Sangeeta U Nayak, MDS; Dr. Srikant Natarajan, MDS; Dr. Arathi Rao, MDS; Dr. Deepa G Kamath, MDS

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 1586-1590

Oral mucosa is affected by various papillary lesions. Any oral lesion raises concern because of its clinical appearance. This case report describes the management of an 8-year-old girl with an exophytic papillary growth on the palatal aspect of 64. The lesion clinically resembled an oral squamous papilloma but did not show any signs of a virally infected lesion histopathologic ally or on immunohistochemistry analysis which was unique with this case.

Assessment of radiological prognostic factors in patients with carcinoma cervix treated with concurrent chemoradiation: A clinical study

Manraj Singh Kang; Taranjeet kaur; Gaurav Jaswal; D P Singh; Gagandeep Singh; Khusbu Goyal

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 3001-3006

Aims & Objective: The present study was undertaken for assessing the radiological
prognostic factors in patients with carcinoma cervix treated with concurrent
chemoradiation.
Materials & methods: A total of 40 patients were included. Only those patients were
included which had histological proven diagnosis of carcinoma of cervix. Patients were
within the age range of 19 to 60 years. Complete demographic and clinical details of all the
patients were obtained. Thorough physical examination of all the patients was carried out.
Treatment planned was 3-dimensional conformal radiotherapy with concurrent
chemotherapy followed by radiotherapy and follow-up for 6 months.
Results: Out of 40 patients, 25 patients had NED after 6 months while in 15 patients were
of residual after 6 months. Among the patients with NED, 16 patients had parametrical
extension of less than lateral pelvic wall while disease dimension was more than 6 cm in 17
patients. Hyponephrosis was present in 2 patients. Among the patients with residual, 10
patients had parametrical extension of less than lateral pelvic wall while disease dimension
was more than 6 cm in 15 patients. Hyponephrosis was present in 5 patients.
Conclusion: Patients with higher parametrical extension upto pelvic wall, hydronephrosis
and greater dimension were associated with pelvic failure of disease at follow-up.

Evaluation of Anticancer effect of Ethanolic extract of Lepidagathis pungens Nees., Whole Plant By MTT Assay- An In Vitro Study

Manoharan Dhanalakshmi; Subramaniam AnandaThangadurai

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 1027-1038

Extracts from natural products, especially plants, have served as a valuable source of diverse molecules in many drug discovery efforts and led to the discovery of several important drugs. Lepidagathis pungens Nees., (L.pungens) is a herb of tropical Asia belonging to the family Acanthaceae. The present study deals with the in vitro anticancer activity of ethanolic extract of L.pungens against L6, Ehrlich Ascites Carcinoma (EAC), human breast cancer cells ( MCF 7), human cervical cells (He La) and human hepatocellular carcinoma cell lines (Hep G2). MTT assay was used to assess the in vitro anticancer activity. The extract at various doses were treated against all the cell lines. The parameters analyzed were percentage of cytotoxicity, percentage of cell viability and IC50 values. In results the ethanolic extract of L.pungens showed more potent activity against MCF 7 and EAC cell lines but moderate activity against He La and Hep G2 cell lines. The anticancer nature of the ethanolic extract is due to the presence of phytoconstituents like flavanoids, alkaloids, phenolic compounds, terpenoids, etc. However, further indepth studies are required before final conclusion on the mechanisms involved could be drawn to explain the observed activity. In conclusion, the ethanolic extract of L.pungens possess anticancer activity against various types of cancer cells, correlated to their total phenolic content.