Online ISSN: 2515-8260

Keywords : Carcinoma


Fibro-epithelial Hyperplasia Mimicking Oral Squamous Papilloma in an 8-year-old child - A Rare Case Report

Dr Ellana Jermiah Joseph, BDS; Dr Razia Haidrus, BDS; Dr Anupama Nayak P, MDS; Dr. Sangeeta U Nayak, MDS; Dr. Srikant Natarajan, MDS; Dr. Arathi Rao, MDS; Dr. Deepa G Kamath, MDS

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 1586-1590

Oral mucosa is affected by various papillary lesions. Any oral lesion raises concern because of its clinical appearance. This case report describes the management of an 8-year-old girl with an exophytic papillary growth on the palatal aspect of 64. The lesion clinically resembled an oral squamous papilloma but did not show any signs of a virally infected lesion histopathologic ally or on immunohistochemistry analysis which was unique with this case.

Assessment of radiological prognostic factors in patients with carcinoma cervix treated with concurrent chemoradiation: A clinical study

Manraj Singh Kang; Taranjeet kaur; Gaurav Jaswal; D P Singh; Gagandeep Singh; Khusbu Goyal

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 3001-3006

Aims & Objective: The present study was undertaken for assessing the radiological
prognostic factors in patients with carcinoma cervix treated with concurrent
chemoradiation.
Materials & methods: A total of 40 patients were included. Only those patients were
included which had histological proven diagnosis of carcinoma of cervix. Patients were
within the age range of 19 to 60 years. Complete demographic and clinical details of all the
patients were obtained. Thorough physical examination of all the patients was carried out.
Treatment planned was 3-dimensional conformal radiotherapy with concurrent
chemotherapy followed by radiotherapy and follow-up for 6 months.
Results: Out of 40 patients, 25 patients had NED after 6 months while in 15 patients were
of residual after 6 months. Among the patients with NED, 16 patients had parametrical
extension of less than lateral pelvic wall while disease dimension was more than 6 cm in 17
patients. Hyponephrosis was present in 2 patients. Among the patients with residual, 10
patients had parametrical extension of less than lateral pelvic wall while disease dimension
was more than 6 cm in 15 patients. Hyponephrosis was present in 5 patients.
Conclusion: Patients with higher parametrical extension upto pelvic wall, hydronephrosis
and greater dimension were associated with pelvic failure of disease at follow-up.

Evaluation of Anticancer effect of Ethanolic extract of Lepidagathis pungens Nees., Whole Plant By MTT Assay- An In Vitro Study

Manoharan Dhanalakshmi; Subramaniam AnandaThangadurai

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 1027-1038

Extracts from natural products, especially plants, have served as a valuable source of diverse molecules in many drug discovery efforts and led to the discovery of several important drugs. Lepidagathis pungens Nees., (L.pungens) is a herb of tropical Asia belonging to the family Acanthaceae. The present study deals with the in vitro anticancer activity of ethanolic extract of L.pungens against L6, Ehrlich Ascites Carcinoma (EAC), human breast cancer cells ( MCF 7), human cervical cells (He La) and human hepatocellular carcinoma cell lines (Hep G2). MTT assay was used to assess the in vitro anticancer activity. The extract at various doses were treated against all the cell lines. The parameters analyzed were percentage of cytotoxicity, percentage of cell viability and IC50 values. In results the ethanolic extract of L.pungens showed more potent activity against MCF 7 and EAC cell lines but moderate activity against He La and Hep G2 cell lines. The anticancer nature of the ethanolic extract is due to the presence of phytoconstituents like flavanoids, alkaloids, phenolic compounds, terpenoids, etc. However, further indepth studies are required before final conclusion on the mechanisms involved could be drawn to explain the observed activity. In conclusion, the ethanolic extract of L.pungens possess anticancer activity against various types of cancer cells, correlated to their total phenolic content.