Online ISSN: 2515-8260

Keywords : anti-fungal

Review of Pharmacological Aspects of Nothapodytes nimmoniana species

B. Durga; A. Julius; S. RaghavendraJayesh

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 1727-1732

Over 100 years of decay, major populace focus on traditional plants for treating massive disease due to the presence of active component. Biologically active compounds present in the medicinal plants have always been of huge curiosity to scientists for focusing on exploring plant products. Nothapodytes foetida (also known as Mappia foetida or Nothapodytes nimmoniana) is an average size tree belonging to family Icacinaceae. It is distributed in Southern India, North India, Srilanka, Myanmar and Thailand. It is an imperative medicinal plant, the foremost source of a potent alkaloid, namely camptothecin, of a wide spectrum of pharmacological activities like anti-cancer, anti-HIV, anti-malarial, antibacterial, anti-oxidant, anti-inflammatory, anti-fungal and also applied in the treatment of anemia. This review article compresses about the phytochemical constituent, pharmacological activity of bioactive component of N.nimmoniana species of root, stem, leaves and bark of the plants.

Synthesis, Characterization And Study Of Oxadiazole Derivatives For Potent Antimicrobial Activity

Shabir Ahmad Sheergojrie; Navneet Singh

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 3757-3769

Four new oxadiazole derivatives, 5-(2-chlorophenyl)-1, 3, 4-oxadiazole-2-amine, 5-(3-nitrophenyl)-1, 3, 4-oxadiazole-2-amine, 4-(5-amino-1, 3, 4-oxadiazole-2-yl)phenol, 5-(3,4-dimethoxyphenyl)-1, 3, 4-oxadiazole-2-amine have been synthesized, characterized and studied for in-vitro antimicrobial activities. The antibacterial studies is carried out against bacteria E.coli, Bacillus subtilis, Micrococcus letteus and the anti-fungal studies is carried out against fungus candida albicans, Sacromyces cervesiae at concentrations 50μg/ml, 100 μg/ml and 150μg/ml. The potency of the derivatives is analysed against standard antibiotic drug ampicillin at 100μg/ml. Compounds 5-(2-chlorophenyl)-1, 3, 4-oxadiazole-2-amine and 5-(3,4-dimethoxyphenyl)-1, 3, 4-oxadiazole-2-amine are found more effective than ampicillin, which may be explored as new analogues in antibiotic category.