Online ISSN: 2515-8260

Keywords : Lymphadenopathy


Srilakshmi Gollapalli,M.P Akarsh,Nadhiya .U ,Naval Kishore Bajaj

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 696-713

Fine Needle Aspiration Cytology (FNAC) is first line of investigation in diagnosing a variety of superficial and deep lesions. It is a easy, quick, cost effective,well tolerated  and reliable technique done  as a  outpatient department  procedure. Lymphadenopathy is clinically important in a myriad of conditions ranging from simple reactive lymphadenitis to neoplastic etiology. In this study, we explain the  utility of FNAC in  lymph node lesions ranging from infectious etiology to malignant lesions and we highlight Tuberculous Lymphadenitis.
Methods: This was a retrospective study and includes a total of  256patients of  all age groups and both sexes presenting with palpable lymphnodes at FNAC clinic of our institute over a period of 3 years .FNAC was conducted with 22-24 Gauge disposable needles attached to  5/10c.c syringes. Smears were fixed in 95% ethyl alcohol and stained with Hematoxylin and Eosin stain. Leishman stain was done on air dried smears. Ziehl- Neelsen (ZN) staining was done wherever required.
Results: Out of a total of 256 patients with   lymphadenopathy subjected to FNAC the commonest site was cervical lymphnodes(57.03%) .Females(54.68%)
 outnumbered males(45.31%) in our study .The commonest lesion  was found to be Granulomatous lymphadenitis(51.95%,followed by reactive
lymphadenitis(23.82%),non suppurative lymphadenitis(10.1%),acute suppurative lymphadenitis(6.25%),Metastatic deposit(5.07%),chronic suppurative lymphadenitis(1.95%) and HodgkinsLympoma(0.78%).
Conclusion: FNAC is a easy to perform,reliable in expensive method in diagnosing lymphadenopathy.In our study the predominant cause of lymphadenopathy was Tuberculous lymphadenitis,followed by reactive lymphadenitis.


Dr P R D Ganesh Basina, Dr Siva Kumar Vulava, Dr BVVD Kiranmayi, Dr. Krishna SwaroopD. S

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 1135-1145

Fine needle aspiration cytology (FNAC) is a simple, safe, reliable rapid and
inexpensive method of establishing the diagnosis in lymph node lesions. The value of FNAC, besides making a
diagnosis lies in early detection, direction of appropriate investigations and treatment options. The present study is
undertaken to study the usefulness of FNAC in diagnosing various lymph node lesions in patients presenting with
lymphadenopathy. Also to determine the pattern of diseases affecting lymph nodes and to study the spectrum of
lesions with respect to age, sex and site of occurrence. To study the distribution of Acid fast bacilli in tuberculous
lymphadenitis using Ziehl Neelsen stain.

Study of usefulness of Weil-Felix test as a simple diagnostic tool for diagnosis of rickettsial fever

Dr. Varun B Kusagur, Dr. Manasa KB

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 1382-1387

Background: Rickettsial infections are the most covert re-emerging infections in present
times. They are incapacitating and notoriously difficult to diagnose, Weil-Felix (WF) test is
classic serological test which is widely available but not widely acceptable because of its low
sensitivity and specificity. Present study was aimed to study of usefulness of Weil-Felix test
as a simple diagnostic tool for diagnosis of rickettsial fever.
Material and Methods: Present study was single-center, prospective, observational study,
conducted in children < 18 years age, hospitalized with fever and presence of one or more of
the following clinical features: Rash, edema, eschar, hepatosplenomegaly, lymphadenopathy
OR had history of contact with pets or live stocks and history of tick-bite.
Results: In the present study maximum number of cases were from school going age group
(53.5%), male (67.4%), from Rural Areas (88.4%) & Tick bite could be demonstrated in
44.2% cases. Based on clinical features Lymphadenopathy was seen mainly 86.00%,
followed by maculopapular rash (76.7%), rash appearing 48-96 hrs. after fever (72.10%),
conjunctival congestion (55.80%), hepatomegaly (48.80%), rash on palms & soles, pedal
edema (34.9%) & purpura (14%). Out of 43 suspected cases, Weil-Felix test was positive in
31 cases (72.1%) and Negative in 12 cases (27.90%).
Conclusion: Rickettsial disease must be strongly suspected with a triad of fever, rash and
lymphadenopathy or having history of tick exposure/ bite and when the cause of fever cannot
be established. Weil Felix test can be carried out for early detection of suspicious casein
resource limited set up.

Clinicopathological analysis of cervical lymph node biopsies in central India

Amit Kumar Niranjan, Nikhil Agrawal, Rukmini Sharma, Dr. Rajendra Kumar Teharia

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 1393-1396

Introduction: Lymphadenopathy is a common clinical problem, usually benign, but malignancy may be associated. To confirm the diagnosis often required a biopsy of lymph nodes. Methods: All patients with cervical lymphadenopathy, more than 4 weeks and size more than 1cm were included in the study and a biopsy were done and sent for histopathological study. Results: Out of total 220 patients, 54.5% (n=120) were males & 45.5% (n=100) were females. The mean age was 38.9±1.02 years & the maximum number of patients were adults (50%). The most common cause of cervical lymphadenopathy was reactive hyperplasia (51.8%) followed by granulomatous infection (17.3%). however, in older adults, carcinoma was also a common cause of cervical lymphadenopathy (40%). Conclusion: The most common histopathological diagnosis of cervical lymph node biopsies in central India were reactive disease and granulomatous infections.

Acute and Chronic Lymphadenopathy – An Overview

Dr T. Alamelu Mangai; Dr K.M.K. Masthan; Dr N.Aravindha Babu

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 1926-1932

LYMPHADENOPATHY (LAP) or ADENOPATHY is a any disease of the lymphnodes which is abnormal in size, number and consistency. Lymphadenopathy is a most common condition in any form of disease which is noticed by a physician .But it is not a peculiar symptom of any disease. An inflammatory type of lymphadenopathy is called as LYMPHADINITIS. In this review Article we can see the classification of lymphadenopathy pathogens, clinical approach and clinical evaluation of lymphadenopathy and differential diagnosis. Depending upon the size and extent of lymphadenopathy we can evaluate the condition of the patient and give appropriate treatment.