Online ISSN: 2515-8260

Keywords : bleeding


Coagulation and Fibrinolysis Profiles of Acute Myeloblastic Leukemia: Preliminary Assessment of Hypercoagulability

Edward Kurnia Setiawan Limijadi; Imam Budiwijono; Indranila Kustarini Samsuria; Purwanto Adhipireno; Wivina Riza Devi

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 607-615

Acute Myeloblastic Leukemia is an abnormality of haematological malignancy that often causes bleeding and death. Coagulation and fibrinolysis examinations are screening parameters that need to be reviewed related to the incidence of bleeding events in AML patients in a hypercoagulability assessment.This was a cross-sectional study conducted at Ulin Regional Hospital Banjarmasin on patients with a recent diagnosis of AML patients for the first time using a consecutive sampling method. The measurement of PT, aPTT, fibrinogen, and D-dimer levels were done at the Diponegoro National Hospital using Coalab-1000 tool. The analysis of the correlation between the
 ncidence of bleeding events with coagulation and fibrinolysis parameters used Fisher's exact test.The significance of the correlation test of the incidence of bleeding events with PT, aPTT, Fibrinogen, and D-dimer were 0.731; 0.086; 0.617; 0.587, and 0.731, respectively.The parameters of PT, aPTT, Fibrinogen and D-dimer were not associated with the incidence of bleeding events. The extension of PT and aPTT in most AML patients is suspected due to the deficiency of coagulation factors. Screening tests of PT, aPTT, fibrinogen and D-dimer levels should be performed in AML patients, although the results do not always show abnormalities

RETROSPECTIVE EVALUATION OF CORRELATION OF POST EXTRACTION HEMORRHAGE AND ANTI COAGULANT THERAPIES IN YOUNGER POPULATION: A PREVALENCE BASED CLINICAL STUDY

Sachin Kumar; Varun Kumar Verma; Karan Sublok; Ashish Kumar Kushwaha; Priyanka Singh; Sheikh Abrar

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 1964-1972

Background and Aim: Post operative bleeding is very common post operative complication seen in extraction cases. Anti coagulant therapies are employed to manage several clinical conditions. Patients those who are already on anti coagulant therapy, can show different patterns of post extraction hemorrhage. Anti coagulant makes blood flow via veins more easily. So, blood will be less likely to make a dangerous blood clot (like thrombosis or embolism). The sole endeavor of present study was to evaluate the correlation of post extraction hemorrhage and anti coagulant therapies in younger population. This study was retrospectively performed to assess the related prevalence also in the studied population. Materials & Methods: Patients case history, follow up case sheet and discharge summaries were explored. Younger age group patients those had undergone single tooth atraumatic extraction for different reasons, were selected for study. Patients who reported to be on anticoagulant therapy for more than one year, were studied in group one. Patients who reported to be on anticoagulant therapy for six to twelve months, were segregated in group two. Patients who reported to be on anticoagulant therapy for less than six months, were studied in group three. Patients not receiving this therapy were served as control group or group four. Post operative bleeding was studied under five categories in each group. These were mild, moderate, severe, uncategorized and no bleeding. Statistical Analysis and Results: Statistical analysis was done by statistical software Statistical Package for the Social Sciences (SPSS). P ≤ 0.05 was considered as statistically significant. Total 84 male and 36 female patients were studied in this study. Therefore, majority of the studied patients were male. In group I, 9 out of 30 patients had no bleeding. However, 8 patients showed severe post operative bleeding. 5 patients showed only mild bleeding. In this group (group I), P value was significant for all five severities of bleeding. In group IV, 23 patients had no post operative bleeding. Nevertheless, only 1 patient showed severe post operative bleeding. Only 1 patient showed mild bleeding. In this group (group IV), P value was significant for patients with no post operative bleeding (0.03). Conclusion: Within the limitations of the study, authors concluded that anti coagulant therapies are significantly affecting post operative bleeding in extraction cases. The relative severity and prevalence of bleeding are also exaggerated by time period of anti coagulant therapy. Patients those who were on anti coagulant therapy for more than one year, showed maximum prevalence and severity of bleeding.

EFFICACY OF HEMOCOAGULASE AS A TOPICAL HEMOSTATIC AGENT AFTER EXTRACTIONS: A REVIEW

Dr. Balakrishnan Ramalingam; Dr. Vijay Ebenezer

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 1933-1936

Extractions are the most common surgical procedures carried out and postextraction bleeding is most commonly seen complication. The aim of this review was to determine the effectiveness of topical hemocoagulase as a hemostatic agent and its role in reducing postextraction bleeding and its comparison to routine saline pressure pack after tooth extraction. Various differences was present between the hemostatic agent and saline pressure pack in relation to pain, swelling, wound healing, bleeding time, and other complications. Topical hemocoagulase is effective in reducing bleeding, pain, and swelling after extraction when compared to saline pressure packs. It also act as a promoter of wound healing.

Retrospective analysis of the birth histories of women who have suffered bleeding in order to optimize approaches to the prediction and prevention of postpartum bleeding

Poyonov O. Yoldoshevich; Karimova N. Nabidjanovna

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 6236-6243

The aim of our study was to retrospectively examine the history of childbirth and the quality of primary care for bleeding and evaluate the prescribed rehabilitation measures for women who have suffered postpartum hemorrhage and massive bleeding. The materials and methods of the study were 242 birth histories with postpartum hemorrhage for the last 6 years (2013-2018) in the city maternity hospital of Bukhara. The average age of the patients was 26.7 ± 1.2 years. The obstetric pathology leading to bleeding mainly consists of uterus hypotonia - 143 (59.1) and large fetus - 68 (28.1), and preeclampsia and DIOV are equal amounts - 33 (13.64). Only about 20% of women who had postpartum hemorrhage underwent early rehabilitation in the form of prescribing contraceptives.The aim of the research was to study the effectiveness of modern principles of stopping postpartum obstetric bleeding. From 127 cases of bleeding in 101 women (79.5%) the childbirth were with the operational method. With the development of blood loss was renderedstepwise ways to stop bleeding. During hemostasis of the bleeding, ligatures were imposed on the ovarian arteries and the ascending branch of the uterine artery for ischemicization of the uterus, which was effective in 30 (30%) women, and in 114 (89.7%) women managed to achieve organ-sparing tactics.