Online ISSN: 2515-8260

Keywords : local drug delivery

Assessment of the Efficacy of Two Local Drug Delivery Systems in the Treatment of Chronic Periodontitis

Dr. Praveen Kumar Bankur; Dr. Kulkarni Avdhoot; Dr. Shruti Jha; Dr. Mohammad Jalaluddin; Dr. Deesha Kumari; Dr. Crystal Runa Soans

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 7137-7143

Aim: Aim of the present study was to assess the efficacy of two local drug delivery systems in the treatment of chronic periodontitis. Materials and Methods: A total of 40 patients aged around 30–55 years were included in the present study.The enrolled patients underwent initial phase therapy which comprised scaling and root planning done by a single operator. Patients who fulfilled the selection criteria for the study were randomly allocated to two groups. Group 1: Tetracycline Fibers, Group 2: Chlorhexidine Gel. The plaque index (PI), the gingival index (GI), and periodontal pocket depth (PPD) were noted during baseline visit (before the local drug delivery), and these indices were rerecorded after 30 days after the local drug delivery. Results: The reduction of mean plaque index score was seen more in group 1 compared to group 2. There was no statistically significant difference found between the groups. The reduction of mean gingival index score and periodontal pocket depth was seen maximum in group 1 compared to group 2. There was a statistically significant difference found between the groups after the intervention.


Dr. Preethi; Rabiathul Adhira M

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 1965-1977

Nonsurgical therapy aims to eliminate bacteria within the microbial biofilm and calcified biofilm microorganisms from the tooth surface and adjacent soft tissues. Complete elimination of such pathogenic microorganisms is probably over-ambitious. However, absence of inflammation in the periodontium results in beneficial clinical changes.In addition, nonsurgical therapy aims to form an environment during which the host can more effectively prevent pathogenic microbial recolonization using personal oral hygiene methods..The various methods utilized in nonsurgical therapy, like hand instrumentation, ultrasonic and sonic scalers, and ablative laser therapy

Effect of locally delivered 0.2% Thymoquinone gel in subjects with Grade C Periodontitis: Clinical, Immunological and Microbiological Assessment

Walid Elamrousy

European Journal of Molecular & Clinical Medicine, 2018, Volume 5, Issue 1, Pages 89-101
DOI: 10.31838/ejmcm.05.01.11

To evaluate the clinical, immunological and microbiological efficacy of local application of Thymoquinone (TQ) gel in subjects with grade C periodontitis. Materials and Methods: Twenty-six individuals of both sexes aged between24 and 37 years, diagnosed as grade C periodontitis with pocket depth ≥5 mm were selected for this study. The patients received a complete prophylaxis including scaling and root planning (SRP) followed by local intrapocket administration of placebo gel in the control group and 0.2% TQ gel in the study group sites. Probing pocket depth (PPD), relative attachment level (RAL), matrix metallo-proteniease-8 (MMP8) concentration in
gingival crevicular fluid (GCF) and Aggregatibacter actinomycetecomitans (A.a) count in subgingival plaque were measured and recorded at baseline and 8 weeks postoperatively. Results: At 8 weeks evaluation period, TQ group showed a significant reduction in PPD, RAL, MMP-8 levels in GCF and A.a count in subgingival plaque samples when compared to the placebo group. Conclusion: The results showed more favorable clinical, immunological and microbiological outcomes with topically administered 0.2 % TQ gel when used as an adjunct to nonsurgical periodontal therapy in subjects with grade C periodontitis.