Keywords : serum microRna 221
Study Of Serum Micro-Rna 221 Expression In Patients With Thyroid Nodules And Its Relation To Outcome
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 9, Pages 577-587
Background: Thyroid nodules are extremely common and are usually benign. 4%-6.5% from thyroid nodulesaremalignant. Among Thyroid cancer investigations manydiagnostic molecular biomarkers were found to have applications in thyroid nodules managment and avoid unnecessary thyroidectomy.(1)
This study aims:To detect value of micro-RNA 221 expression in sera of Patients with thyroid nodules and its relation to outcome after surgery.
Patients and Methods: Forty-five adult subjects aged between 18 to 70-years old who were diagnosed with suspicious thyroid nodules that required total thyroidectomy were offered participation in the study. In addition, five healthy Subjects, were included as a control group, based on the patient’s history, physical examination, US and FNAB findings. Patients who had thyroid nodules with U/S pattern suggestive of malignant potential (TIRADS score ≥ 3),also with indeterminate FNAB results (Bethesda III, IV)were selected. Samples of human plasma were collected from selected patients visiting outpatient clinics. Results was correlated with postoperative pathology results.
Results: In our study there was no significant difference regarding outcome in patients (benign or malignant) with respect to serum microRna 221. There was a significant difference between benign and malignant outcomes regarding size of dominant nodules by ultrasound with a mean value equals 4.6 cm in largest dimension in patients with malignant thyroid nodules and p value equals 0.027 indicating increased size of nodule may be associated with increased risk of malignancy.