Online ISSN: 2515-8260

Keywords : Amino acid

Tryptophan As A Nutraceutical – Clinical And A Critical Review

M. R. Suchitra, P. Krubaa, S. Parthasarathy

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 9423-9429

Nutraceutical is a combination of the words "nutrition" and "pharmaceutics." The term refers to substances separated from herbal products, dietary supplements, and processed foods such as cereal grains, beverages, and soups, which are being used both as a nutrient and medicine. Ginseng, Echinacea, glucosamine, green tea, flavonoids, lycopene, lutein, folate, and cod liver oil are some popular nutraceuticals. Most nutraceuticals have diverse therapeutic attributes. Tryptophan (Trp) is an amino acid that is required in the human diet. It is essential for many metabolic functions. Trp levels can be used by clinicians to diagnose different metabolic disorders and the associated symptoms with those ailments. Furthermore, due to the Trp relationship with the biosynthetic pathways of serotonin (5-HT) and melatonin, dosing with this amino acid is being regarded in the treatment of depressive disorders and sleep disturbances. It is also used to treat cognitive disorders, anxiety, and neurodegenerative diseases. Diminished serotonin secretion has been linked to autism spectrum disorder, obesity, anorexia and many other diseases.   The literature strongly suggests that Trp plays an important role in the proper functioning of the brain-gut axis. Chicken, turkey, red meat, milk, pork, eggs fish, beans, nuts, seeds, and oatmeal, are all high in tryptophan. Tryptophan has a reference dietary intake (RDI) of 4mg per kilogramme of body weight. As a result, a 70kg person should require nearly 280mg of tryptophan per day. The chemical is available as 500 mg capsule in the market as medicine. The rare side effect of an abnormal concomitant intake of the nutraceutical with certain antipsychotic drugs is serotonin syndrome. The described eosinophilic myalgia syndrome was later found to be not associated with this nutraceutical. The drug has got a few side effects and should be prescribed by either a qualified physician or a specialist in human nutrition.

Comparative study of staplersvs simple interrupted vs sub-cuticular method of skin closure of surgical wounds

Dr. Ankit Mohan Das, Dr. JagadambaSharan, Dr. MohitBiswas

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 1926-1933

Aim: To compare staplers vs simple interrupted vs sub-cuticular method of skin closure of
surgical wounds.
Material and method:The present randomized prospective study was conducted in the
Department of Surgery at Rohilkhand Medical College and Hospital, Bareilly from January
2020 to October 2021 among 150 subjects who underwent surgical procedures. Equal number
of patients was allotted to 3 groups by random envelope allocation method i.e. Group
A(Stapled skin closure), Group B(Interrupted skin closure) and Group C(Sub cuticular skin
closure). Following the completion of closure, an antiseptic medicated cream was applied
followed with a protective dressing for the first 24–72 h. Subcutaneous Drains were placed in
selective cases according to infection and were kept till the drain content was minimal. All
patients were given IV antibiotics for 5–7 days postoperatively. The closures were removed
after an interval of 10–14 days, first removing the alternate sutures and then the remaining
sutures after few days and pain on removal was recorded using VAS.
Results: Postoperative pain score at discharge was least in sub-cuticular group followed by
stapled and interrupted skin closure group, though statistically there was no difference.
Conclusion: In this we found that time required for skin closure (in seconds) was least in
stapled skin closure group while pain and POSAS score was minimum in sub-cuticular skin
closure group. Wound infection was present maximum and minimum among sub-cuticular
and interrupted skin closure group respectively

Role of Parenteral Amino Acid in Patients of Diabetic Foot Ulcer

Dr. Ankit Mohan Das,Dr. Jagadamba Sharan, Dr. Mohit Biswas

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 2071-2079

Aim: To analyse the role of amino acids among subjects with type 2 diabetes having foot
Material and method: The present study was conducted in the Department of Surgery,
Rohilkhand Medical College and Hospital, Bareilly from February 2020 to March 2021. The
study comprised of 60 patients, aged 18 years and above, suffering from diabetic foot ulcer.
Patients were divided into two groups i.e. group A and B. Patients of group A continued to
take diabetic diet as they were taking before while patients of group B were given IV amino
acid (200ml) on alternate day till 15th day in addition to the diet they were taking before.
Ulcers of all patients were properly cleaned and dressed under aseptic condition with normal
saline and povidone iodine everyday, wound debridement was done as required. Ulcers were
assessed on day 0, 5, 10 and 15.
Results: Mean cholesterol increased in group A while it decreased in group B at different
intervals with statistically insignificant difference as p>0.05. At the end of study, normal
healing was found among 26.67% and 66.67% of the subjects in group A and B respectively.
Major haematoma was reported only in group A and that among 10% of subjects. Hence
healing was observed better among group B subjects.
Conclusion: It can be concluded from the results that among subjects with diabetic foot
ulcers, amino acid administration leads to better healing and satisfaction among the patients.
Therefore, amino acids supplement should be given to diabetic foot ulcer subjects

Comprehensive Study Of The Chemical Composition Of The Plant Elaeagnus Angustifolia L

Artikova G.N.; Ishimov U.Zh; Sobirova F.A; Genzhemuratova G.P.; Bektursynova A.P.; Matchanov A.D.

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 3320-3331

The data on the study of the amino acid, fat-acid, carbohydrate and vitamin composition of the plant Elaeagnus angustifolia L. are presented. The study of the amino acid composition shows that among the studied amino acids, the main ones are glycine, asparagine, proline, cysteine and tyrosine. The high concentration among fatty acids is defined for oleic (23,6%), linoleic (67,5%), myristic (5,1%) and palmitic (1,8%) acids. The study of the qualitative and quantitative monosaccharide composition showed that 27,37% of fructose and 35,44% of glucose are predominant in the water-soluble polysaccharide complex. The water-soluble revealed quantitative vitamin content showed B6 (68,78 mg/%) and B9 (232,3 mg/%).