Online ISSN: 2515-8260

Keywords : IHC

Role of EGFR, HER2 and P53 in the Spectrum of Oesophageal Lesions

Lachhima Bhandari, Mohanvir Kaur, Vijay Kumar Bodal, Chettan Dass

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 5676-5687

Background:Oesophageal cancer is the eighth most common cancer and sixth in cancer
related mortality, worldwide. The current study was carried out to see the role of three
markers (P53, HER2, EGFR) in various oesophageal lesions, their association in cancer
progression and their role as tumour markers.
Materials and Methods: Study was conducted on 100 cases of oesophageal lesions
consisting of both neoplastic and non-neoplastic spectrum. Immunohistochemistry was
performed on all the specimens for three markers as per the set criteria and expression
of these markers was studied and scoring was done accordingly.
Results: Present study was conducted on 100 cases with oesophageal lesions both
neoplastic and non-neoplastic. Parameters like age, gender, family history, alcohol
intake, cigarette smoking and location of lesion in oesophagus were also studied.
Expression of P53, Her2, EGFR were studied using IHC.
Conclusion: P53, HER2 and EGFR show a strong association with EC and
premalignant lesions, the absence of their expression in normal oesophageal tissue and
non-neoplastic conditions, points out their role in development of EC and tumour
progression. Out of the three markers, P53 has the strongest association with EC. HER2
overexpression was more in case of EAC than ESCC, indicating its importance in
guiding further treatment. EGFR over- expression was noted in fewer cases.


Andleeb Manhas; Amani Mahajan; Sadaf Antoo; Monika Negi; Muzaffar Parray; Swati Parhar

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 1171-1183

Introduction: Odontogenic lesions are relatively common lesions and account for a substantial part of total oral biopsies by an oral pathologist. Some lesions like the keratocysticodontogenic tumor (KCOT) exhibit a locally aggressive behavior.Myofibroblasts (MFs) are specialized fibroblasts. These cells play a role in physiological processes like wound healing and pathologic conditions like reactive lesions, benign tumors, locally aggressive tumors and malignancies affecting oral cavity. Earlier, it was believed that the presence of Myofibroblasts (MFs) at the invasive front of the tumor was a part of the host defence mechanism against the tumor, but recent studies suggest that the presence of these cells at the tumor front promotes the growth and invasion of the tumor. The presence of Myofibroblasts has been reported in the stroma of many odontogenic lesions, including both cysts and tumors. Studies conducted both on odontogenic cysts and tumors revealed that the cells were particularly more in lesions with locally aggressive behavior like odontogenic keratocyst (OKC).
The aim of the study was to evaluate the role of Myofibroblasts in KeratocysticOdontogenic Tumor and its objectives were to compare the expression and distribution pattern of Myofibroblasts in KeratocysticOdontogenic Tumor (KCOT) as compared to their expression in Oral Squamous Cell Carcinoma and to derive a co-relation between the stromal Myofibroblasts and the known biologic behavior of KeratocysticOdontogenic Tumor (KCOT).