Online ISSN: 2515-8260

Keywords : Chlorhexidine


Comparison of the Effects of the Leaf Extract and Gum of Pistacia atlantica and Chlorhexidine on the Growth Initiation of S. mutans: An in vitro Study

Saeedeh Mokhtari; Ataollah Ahrari; Zahra Hosseini

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 2688-2697

Background: Dental caries is one of the most prevalent infectious diseases, the main etiologic factor of which is Streptococcus mutans. The present study aimed to evaluate the effect of the leaf extract and gum of Pistacia atlantica on the growth inhibition of S.mutans in comparison to chlorhexidine (CHX).
Methods: In the present in vitro study, the antibacterial effects of the extract and gum of this plant were evaluated in comparison to that of CHX. The microbial sensitivity was evaluated by determining the diameter of the growth inhibition zone. In addition, the turbidity test was used to determine the minimum inhibitory concentration (MIC) of the materials against S.mutans.
Results: No growth inhibition zones for S.mutans were detected around the materials derived from P. atlantica, while a 24-mm growth inhibition halo formed around CHX. The MIC values for CHX and the leaf extract and gum of P. atlantica were 1.256, 1.8 and 1, respectively.
Conclusion: In general, the present study showed that the antibacterial effect of CHX on S. mutans was higher than those of P. atlantica derivatives. In addition, the P. atlantica leaf extract exhibited higher antibacterial activity compared to its gum, which is used as chewing gum in some regions

ROLE OF TRIPHALA MOUTHWASH IN GINGIVITIS AND PERIODONTITIS- A NARRATIVE REVIEW

M. Bhuvaneswari; Preetha Chaly Elizabeth; J. E. Nijesh

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 1133-1140
DOI: 10.31838/ejmcm.07.09.118

Aim:To assess the effectiveness of Triphala against gingivitis and periodontitis. Triphala is a mixture of three myrobalans known as Emblica officinalis (Amalaki), Terminalia bellerica (Bibhitaki), Terminalia chebula (Haritaki)
Methods: A search of the PubMed, Google Scholar, Web of Science and Scopus database was conducted.
Results: Triphala possess varying therapeutic potentials. Particularly antimicrobial and anti-inflammatory, anti collagenase and anti oxidant properties are of greater importance in dentistry. Various studies show that Triphala is equally as effective as a standard chemotherapeutic agent that is chlorhexidine in treatment and prevention of gingivitis and periodontitis respectively.
Conclusion: Triphala can be a promising therapeutic agent in treatment of gingivitis and peridontitis with no side effects on long term use.

Comparative evaluation of efficacy of sub-gingivally delivered 2% indigenously prepared curcumin gel and 1% commercially available hexigel as an adjunct to scaling and root planing in chronic periodontitis patients : A split mouth randomized controlled clinical trial.

Anupama Desai; Harish Kumar; Roquaiya Nishat; Shivanand Aspalli; Nagappa. G; YAnand Kumar

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 5299-5312

Aim: To evaluate and compare the clinical efficacy of subgingivally delivered curcumin gel and hexigel as an adjunct to scaling and root planing in chronic periodontitis patients.
Materials and method:A total of 12 subjects of age 18-55years were randomly selected for the study from the Out Patient Department. A total of 36 sites with pocket depths ≥5 mm were chosen as a split mouth design at three different sites in the same patient. After scaling and root planning, in Group I -2% curcumin gel, in Group II- Chlorhexidinegel(Hexigel ) and in Group III-placebo gel (control)was placed sub-gingivally. Clinical parameters such as gingival index and plaque index were recorded at baseline, 7 days and 21 days. Pocket depth was checked at baseline, 21 and 45 days.
Results:All the groups showed statistically significant reduction in gingival, plaque indices and pocket depth. Group I(curcumin)as a local delivery agent showedcomparable results in terms of pocket depth reduction as group II (Hexigel).
Conclusion:Curcumin gel showed effective results and thus, can be used as an alternate to chlorhexidine gel in management of chronic periodontitis patient without any side effects

Comparison Of The Antibacterial Efficacy Of Calcium Hydroxide When Mixed With Zamzam Water, Normal Saline And 2% Chlorhexidine - An In Vitro Study

Dr. Mubashir Baig Mirza; Dr. Faisal Suliman Alhedyan; Ayidh Muflih Al Qahtani

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 1184-1193

Aim: To investigate the antimicrobial properties of calcium hydroxide when mixed with three vehicles namely Zamzam water, Normal saline and 2% Chlorhexidine.
Materials & Method: 6 plates of nutrient broth and S. aureus culture were prepared. 2 (5*3 mm) wells were prepared in one plate and is used as control. 3 wells each were prepared in the remaining 5 plates and filled with freshly prepared mix of calcium hydroxide with the three vehicles (5 wells were filled with each mix). The same process was repeated using 6 plates containing nutrient broth and B. subtilis culture. The plates were then incubated for 24 hours and the Zone of inhibition (ZOI) was measured. The pH of each mixture was also measured by using a pH meter. The data was analyzed by ANNOVA test and compared by using Tukey HSD test.
Result: The mean value of ZOI for Ca(OH2) and Zamzam was statistically significant when tested against both the bacteria. The pH of 12.26, 11.90 and 12.10 was achieved for Ca(OH2) and Zamzam, Ca(OH2) and Normal saline and 2% Chlorhexidine and Ca(OH2).
Conclusion: Calcium hydroxide powder mixed with Zamzam water exhibited the highest pH of 12.26 and showed statistical significant antimicrobial difference when compared to other medicaments. However further in depth scientific investigations regarding the properties and safety of Zamzam water and World health organization (WHO) approval would be required before considering its clinical use.