Online ISSN: 2515-8260

Keywords : Chlorhexidine


M. Bhuvaneswari; Preetha Chaly Elizabeth; J. E. Nijesh

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 1133-1140

Aim:To assess the effectiveness of Triphala against gingivitis and periodontitis. Triphala is a mixture of three myrobalans known as Emblica officinalis (Amalaki), Terminalia bellerica (Bibhitaki), Terminalia chebula (Haritaki)
Methods: A search of the PubMed, Google Scholar, Web of Science and Scopus database was conducted.
Results: Triphala possess varying therapeutic potentials. Particularly antimicrobial and anti-inflammatory, anti collagenase and anti oxidant properties are of greater importance in dentistry. Various studies show that Triphala is equally as effective as a standard chemotherapeutic agent that is chlorhexidine in treatment and prevention of gingivitis and periodontitis respectively.
Conclusion: Triphala can be a promising therapeutic agent in treatment of gingivitis and peridontitis with no side effects on long term use.

Comparison Of The Antibacterial Efficacy Of Calcium Hydroxide When Mixed With Zamzam Water, Normal Saline And 2% Chlorhexidine - An In Vitro Study

Dr. Mubashir Baig Mirza; Dr. Faisal Suliman Alhedyan; Ayidh Muflih Al Qahtani

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 1184-1193

Aim: To investigate the antimicrobial properties of calcium hydroxide when mixed with three vehicles namely Zamzam water, Normal saline and 2% Chlorhexidine.
Materials & Method: 6 plates of nutrient broth and S. aureus culture were prepared. 2 (5*3 mm) wells were prepared in one plate and is used as control. 3 wells each were prepared in the remaining 5 plates and filled with freshly prepared mix of calcium hydroxide with the three vehicles (5 wells were filled with each mix). The same process was repeated using 6 plates containing nutrient broth and B. subtilis culture. The plates were then incubated for 24 hours and the Zone of inhibition (ZOI) was measured. The pH of each mixture was also measured by using a pH meter. The data was analyzed by ANNOVA test and compared by using Tukey HSD test.
Result: The mean value of ZOI for Ca(OH2) and Zamzam was statistically significant when tested against both the bacteria. The pH of 12.26, 11.90 and 12.10 was achieved for Ca(OH2) and Zamzam, Ca(OH2) and Normal saline and 2% Chlorhexidine and Ca(OH2).
Conclusion: Calcium hydroxide powder mixed with Zamzam water exhibited the highest pH of 12.26 and showed statistical significant antimicrobial difference when compared to other medicaments. However further in depth scientific investigations regarding the properties and safety of Zamzam water and World health organization (WHO) approval would be required before considering its clinical use.

Comparative evaluation of efficacy of sub-gingivally delivered 2% indigenously prepared curcumin gel and 1% commercially available hexigel as an adjunct to scaling and root planing in chronic periodontitis patients : A split mouth randomized controlled clinical trial.

Anupama Desai; Harish Kumar; Roquaiya Nishat; Shivanand Aspalli; Nagappa. G; YAnand Kumar

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 5299-5312

Aim: To evaluate and compare the clinical efficacy of subgingivally delivered curcumin gel and hexigel as an adjunct to scaling and root planing in chronic periodontitis patients.
Materials and method:A total of 12 subjects of age 18-55years were randomly selected for the study from the Out Patient Department. A total of 36 sites with pocket depths ≥5 mm were chosen as a split mouth design at three different sites in the same patient. After scaling and root planning, in Group I -2% curcumin gel, in Group II- Chlorhexidinegel(Hexigel ) and in Group III-placebo gel (control)was placed sub-gingivally. Clinical parameters such as gingival index and plaque index were recorded at baseline, 7 days and 21 days. Pocket depth was checked at baseline, 21 and 45 days.
Results:All the groups showed statistically significant reduction in gingival, plaque indices and pocket depth. Group I(curcumin)as a local delivery agent showedcomparable results in terms of pocket depth reduction as group II (Hexigel).
Conclusion:Curcumin gel showed effective results and thus, can be used as an alternate to chlorhexidine gel in management of chronic periodontitis patient without any side effects