Online ISSN: 2515-8260

Keywords : Inflammatory bowel disease (IBD)

Evaluation of Toll-like Receptors in Children with Inflammatory Bowel Disease

Hosna Yousef Saleh Yousef, Hatem Mohammed Elsaid Hussein, Mohamed Abd-Elkader Abdallah Almalky, Ahmed Mohamed MoradAsaad

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 3928-3937

Background:Inflammatory bowel disease is a chronic inflammation of gastro- intestinal tract
(GIT), it include two forms, Ulcerative Colitis (UC) and Crohn's disease. Including ulcerative
colitis (UC) and Crohn's disease (CD), are chronic inflammatory disorders of the
gastrointestinal tract that begin most commonly during adolescence and young adulthood. In
patients with IBD, host genetic, environmental, and microbial influences converge and result in
a dysregulated mucosal immune response against the commensal intestinal microbiota. Cellular
receptors in the innate immune system are fundamental and recognize pathogenic molecules to
trigger immune responses. Additionally, some toll-like receptor (TLR) polymorphisms/mutations
have been identified and directly linked to IBD. Genetic alterations of these receptors might
change the composition of microbiota in the gut. Therefore, receptors of the innate immune
system, such as TLRs, impact many aspects of IBD etiology, including immune responses,
genetics, and microbiota

Oral Manifestation of Inflammatory Bowel Disease in Tertiary Care Centre Hospital in South-Eastern Part of India: A Prospective Study

Dr. Sanat Kumar Bhuyan; Dr. Ruchi Bhuyan; Dr. Manoj Sahu; Akankshya Sahu; Sidhant Bhuyan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 813-818

Background: Cohn’s disease (CD) and ulcerative colitis (UC) remain two different chronic digestive disease that coming below the inflammatory bowel disease (IBD) group. Abdominal cramps, vomiting, and ulceration of the digestive tract are all signs of IBD. Follic acid and ironanaemia have occurred due to improper absorption of vitamins B,& D. Bothmalnutrition and anaemia cannister source severe oral health problems, along with erythema, oedema, and angular cheilitis, burning mouth syndrome i.e. sensation in the mouth, candidiasis, lichen planus and gingivitis. Aim: The main aim of the study was to record the different oral events in patients with IBD in a tertiary carehospital in south eastern part of India. Methods: The study included 100 patients with inflammatory bowel disease. All patients had an oral examination and data was collected in prescribed format. Results:Out of 100 patients in 54 patients IBD were studied i.e. 42 CD patients and 12 UC patients.CD was most frequently seen in female (66.66%) than male (33.33%) patients and age group ranged from 31 years to 60 years. More possibilities of IBD seen in patients having poor nutritional status habits, bruxism seen in 53 IBD patients i.e. 42 patients having CD and 11 patients having UC, temporomandibular disorder also seen and most frequent of hyper mobility in 35 patients and clicking in 18 patients.Decayed teeth mostly seen i.e. 46.3% , filled teeth was 42.6% and missing teeth was 11.1%. The most frequent findings were those of periodontitis (85.18%) and gingivitis (85.18%) followed by oral ulcer (81.48%), lip swelling (77.77%) and other lesions like gingival erosion (66.66%), lip crust (79.62%), mucosal tags (55.55%) and mucosal erosions (5.55%) were found in patients and these were highly seen in CD patients (77.77%) than UC patients (22.22%). Conclusion: Systematic oral manifestations may be considered as the initial diagnostic evaluation of patients with suspected CD. Early diagnosis will result in better treatment and pronostics for the patient.